The aim of this study is analyzing the particulate matter (PM10) concentrations on the days when extreme pressure values are measured for Mega City Istanbul. This study covers the 6-year period between March 01, 2013 and March 01, 2019. Meteorological data were obtained from the Turkish State Meteorological Service (TSMS). The values of air pollutants (PM10) are obtained from the Ministry of Environment and Urbanization. According to the results, the highest pressure value was measured on December 08, 2016 with 1040 hPa and the lowest pressure was measured on January 18, 2018 with 990 hPa in this 6-year period. For these two extreme days, meteorological analysis (synoptic card, 850 hPa, sounding data from Istanbul, satellite imagery) was performed and the changes in the values of air pollutants were analyzed. According to the results, there was no significant change at the particulate matter (PM10) concentrations measured on the days when the highest and lowest pressure values were measured compared to the average PM10 values of the city. The correlation coefficient is - 0.74 for December 08, 2016, when the highest pressure was measured, and 0.29 for January 18, 2018, when the lowest pressure was measured. According to the results, there was no significant relationship between hourly pressure changes and hourly mean PM10 values on the days when the highest and lowest pressure values were measured. This result shows that the change in PM10 is not directly dependent on pressure and there are situations where other meteorological parameters may also be effective.