Evaluation of Antifungal Activity of Some Benzothiazole Derivatives
Yıl: 2019 Cilt: 12 Sayı: 4 Sayfa Aralığı: 407 - 412 Metin Dili: İngilizce DOI: 10.30607/kvj.595819 İndeks Tarihi: 05-02-2021
Evaluation of Antifungal Activity of Some Benzothiazole Derivatives
Öz: The antifungal activity of the previously synthesized compounds was evaluated in order to provide solutions tothe candida-induced diseases in animals. In the present study, 10 benzothiazole derivatives (4a-4j) were resynthesized to evaluate their antifungal activity. IR, 1HNMR, 13C-NMR and HRMS (Infrared Spectroscopy, 1HNuclear Magnetic Resonance Spectroscopy, 13C Nuclear Magnetic Resonance Spectroscopy, High ResolutionMass Spectrometry) spectroscopic methods, determined the structure of the synthesized compounds.MIC50(Minimum Inhibitory Concentration) values of the re-synthesized compounds against Candida species wereevaluated by in vitro experiments. As a result of activity studies, it was found that compounds 4c and 4d showedsignificant activity. Compound 4d was found to be the most potent derivative against Candida krusei with a MIC50value of 1.95 µg / mL.
Anahtar Kelime: Bazı Benzotiyazol Türevlerinin Antifungal Aktivitesinin Değerlendirilmesi
Öz: Hayvanlarda oluşan candida kaynaklı hastalıklara çözüm üretmek amacıyla daha önceden sentezi yapılmış bileşikler benzer metot kullanarak tekrar sentezlenmiş ve antifungal etkinlikleri değerlendirilmiştir. Mevcut çalışmada, 10 tane benzotiyazol türevi bileşik (4a-4j), antifungal aktivitelerini değerlendirmek üzere yeniden sentezlenmiştir. Sentezlenen bileşiklerin yapı tanımlamaları IR, 1HNMR, 13C-NMR ve HRMS (Kızılötesi Spektroskopi, 1H Nükleer Manyetik Rezonans Spektroskopisi, 13C Nükleer Manyetik Rezonans Spektroskopisi, Yüksek Çözünürlüklü Kütle Spektrometresi) spektroskopik yöntemleri kullanılarak gerçekleştirilmiştir. Yeniden sentezlenmiş bileşiklerin Candida türlerine karşı MIC50 (Minimum İnhibitör Konsantrasyon) değerleri in vitro deneyler yapılarak değerlendirilmiştir. Yapılan aktivite çalışmaları sonucunda 4c ve 4d bileşikleri önemli aktivite göstermiştir. 4d bileşiğinin Candida krusei’ye karşı 1.95 µg / mL MIC50 değeri ile güçlü bir türev olduğu bulunmuştur.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | OSMANİYE D, SAGLIK B, ACAR ÇEVİK U, ESER M (2019). Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. , 407 - 412. 10.30607/kvj.595819 |
| Chicago | OSMANİYE DERYA,SAGLIK BEGÜM NURPELIN,ACAR ÇEVİK ULVİYE,ESER MUSTAFA Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. (2019): 407 - 412. 10.30607/kvj.595819 |
| MLA | OSMANİYE DERYA,SAGLIK BEGÜM NURPELIN,ACAR ÇEVİK ULVİYE,ESER MUSTAFA Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. , 2019, ss.407 - 412. 10.30607/kvj.595819 |
| AMA | OSMANİYE D,SAGLIK B,ACAR ÇEVİK U,ESER M Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. . 2019; 407 - 412. 10.30607/kvj.595819 |
| Vancouver | OSMANİYE D,SAGLIK B,ACAR ÇEVİK U,ESER M Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. . 2019; 407 - 412. 10.30607/kvj.595819 |
| IEEE | OSMANİYE D,SAGLIK B,ACAR ÇEVİK U,ESER M "Evaluation of Antifungal Activity of Some Benzothiazole Derivatives." , ss.407 - 412, 2019. 10.30607/kvj.595819 |
| ISNAD | OSMANİYE, DERYA vd. "Evaluation of Antifungal Activity of Some Benzothiazole Derivatives". (2019), 407-412. https://doi.org/10.30607/kvj.595819 |
| APA | OSMANİYE D, SAGLIK B, ACAR ÇEVİK U, ESER M (2019). Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal, 12(4), 407 - 412. 10.30607/kvj.595819 |
| Chicago | OSMANİYE DERYA,SAGLIK BEGÜM NURPELIN,ACAR ÇEVİK ULVİYE,ESER MUSTAFA Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal 12, no.4 (2019): 407 - 412. 10.30607/kvj.595819 |
| MLA | OSMANİYE DERYA,SAGLIK BEGÜM NURPELIN,ACAR ÇEVİK ULVİYE,ESER MUSTAFA Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal, vol.12, no.4, 2019, ss.407 - 412. 10.30607/kvj.595819 |
| AMA | OSMANİYE D,SAGLIK B,ACAR ÇEVİK U,ESER M Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal. 2019; 12(4): 407 - 412. 10.30607/kvj.595819 |
| Vancouver | OSMANİYE D,SAGLIK B,ACAR ÇEVİK U,ESER M Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal. 2019; 12(4): 407 - 412. 10.30607/kvj.595819 |
| IEEE | OSMANİYE D,SAGLIK B,ACAR ÇEVİK U,ESER M "Evaluation of Antifungal Activity of Some Benzothiazole Derivatives." Kocatepe Veterinary Journal, 12, ss.407 - 412, 2019. 10.30607/kvj.595819 |
| ISNAD | OSMANİYE, DERYA vd. "Evaluation of Antifungal Activity of Some Benzothiazole Derivatives". Kocatepe Veterinary Journal 12/4 (2019), 407-412. https://doi.org/10.30607/kvj.595819 |
