TY  - JOUR
TI  - Effects of Chrysin Against Isoniazid-Induced Lung Injury in Rats
AB  - The aim of the study was to investigate the effects of chrysin (CH), one of the natural flavonoids, againstisoniazid lung damage caused by isoniazid (INH), which was widely used in the treatment of tuberculosis. MaleSprague-Dawley rats were randomly divided into five groups: a control group, INH-treated group, CH alonetreated group 50 mg / kg, INH + CH 25 mg / kg treated group, and INH+ CH 50 mg / kg treated group. It wasdetermined that INH caused oxidative damage by decreasing antioxidant enzyme activities such as glutathioneperoxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) and increasing lipid peroxidation (LPO). Inaddition, it was found that the administration of CH to INH-treated rats increased GSH level and antioxidantenzyme activities, and decreased lipid peroxidation. It was observed that the nuclear factor erythroid 2 relatedfactor 2 (Nrf-2) and oxygenase-1 (HO-1) expression levels were up-regulated in the INH-treated group, and theexpression of NF-κB increased in the INH-treated group in the immunohistochemical examination, and the CHadministration, on the other hand, decreased the levels of these markers. Taken together, these results suggestedthat CH had beneficial effects in INH-induced lung toxicity by maintaining the oxidant-antioxidant balance anddecreasing NF-κB, Nrf-2, and HO-1 expressions.
AU  - özdemir, selçuk
AU  - ÇOMAKLI, Selim
AU  - KANDEMİR, Fatih Mehmet
AU  - KÜÇÜKLER, Sefa
DO  - 10.30607/kvj.709842
PY  - 2020
JO  - Kocatepe Veterinary Journal
VL  - 13
IS  - 2
SN  - 1308-1594
SP  - 161
EP  - 171
DB  - TRDizin
UR  - http://search/yayin/detay/394195
ER  -