Yıl: 2004 Cilt: 4 Sayı: 1 Sayfa Aralığı: 32 - 38 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals

Öz:
Amaç: Konjestif kalp yetersizliği (KKY) tedavisinde Türkiyede üniversite hastanelerinde uygulanan tedavi yöntemlerini araştırmaktır.Yöntem: Çalışmaya 16 üniversite hastanesinde retrospektif olarak incelenen 661 hasta alındı. Hastaların hastaneye kabulden önceki, hastanede kaldıkları süre içindeki tedavileri, fonksiyonel durumu, KKY’nin etyolojisi ve laboratuar bulguları incelenerek kaydedildi. Bulgular: Çalışma hastalarımızın yaş ortalamaları 61±12 yıl, hastanede ortalama kalış süreleri 10±6 gündü. İskemiye bağlı KKY erkeklerde daha sık (%72 karşı %46, p<0.001), hipertansiyon ve romatizmal KKY kadınlarda daha sıktı (sırasıyla kadın-erkek %27 karşı %19 p<0.001 ve %24 karşı 9%, p<0.001). Hastaneye kabulde hastaların %90’nı NYHA’ya göre III-IV. grupta, taburcu edildiklerinde %2’si IV. gruptaydı. Erkeklerde sigara içme oranı kadınlardan fazlaydı (%68 karşı %12). Elektrokardiyografileri incelenen (%81) hastaların %35’inde atriyal fibrilasyon mevcuttu. Hastanede yattıkları süre içerisinde hastaların %77’sinde anjiyotensin konverting enzim (ACE) inhibitörü, %95’inde diüretik, %76’ında dijitalis, %85’inde nitrat, %3’ünde beta bloker, %86’sında aspirin, %44’ünde antikoagülan, %10’unda kalsiyum antagonisti, %42’sinde pozitif inotropik ajanlar ve %15’inde antiaritmik ajanlar kullanıldı. Sonuç: Konjestif kalp yetersizliğinin tedavisinde önemli bir dönüm noktası olan ACE inhibitörleri henüz yeterli düzeyde kullanılmamaktadır. Konjestif kalp yetersizliğinde beta bloker tedavisi özendirilmelidir.
Anahtar Kelime: Hospitals, University Turkey Retrospective Studies Heart Failure, Congestive Epidemiologic Studies Angiotensin-Converting Enzyme Inhibitors

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971;285:1441-6.
  • 2. McMurray JJV, Stewart S. Epidemiology, aetiology, and prognosis of heart failure. Heart 2000;83:596-602.
  • 3. Mosterd A, Hoes AW, Bruyne MC at al. Prevalence of heart failure and left ventricular dysfunction in the general population. Eur Heart J 1999;20:447-55.
  • 4. McMurray J, McDonagh T, Morrison CE, Dargie HJ. Trends in hospitalization for heart failure in Scotland 1980-1990. Eur Heart J 1993;14:1158-62
  • 5. The SOLVD investigattors. Effect of enalapril on mortality and development of heart failure in symptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992;327:685-91.
  • 6. Sutton GC. Epidemiologic aspects of heart failure. Am Heart J 1990;120:1538-40.
  • 7. Cowie MR.Annotated references in epidemiology. Eur J Heart Failure 1999;1:101-7.
  • 8. Flather M, Yusuf S, Kober L et al. Long-term ACE-inhibitor therapy in patients with heart failure or left ventricular dysfunction: a systematic overview of data from individual patients. ACE-Inhibitor Myocardial Infarction Collaborative Group. Lancet 2000;355:1575-8.
  • 9. Williams JF Jr, Hlatky MA, Bristow MR, et al. Guidelines for the evaluation and management of heart failure. Report of the American College of Cardiology/American Heart association task force on practice guidelines (committee on evaluation and management of heart failure). J Am Coll Cardiol 1996;26:1376-98.
  • 10. Gooding J, Jette AM. Hospital readmissions among the elderly. J Am Geriatr Soc 1985;33:595-601.
  • 11. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525-33.
  • 12. Packer M, Gheorghiade M, Young JB, et al. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. N Engl J Med 1993;329:1-7.
  • 13. Uretsky BF, Young JB, Shahidi FE. Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED Trial. J Am Coll Cardiol 1993;22:955-62.
  • 14. Rich MW, Brooks K, Luther P. Temporal trends in pharmacotherapy for congestive heart failure at an academic medical center: 1990-1995. Am Heart J 1998;135:367-72.
  • 15. Lechat P. Prevention of heart failure progression: current approaches. Eur Heart J 1998;19 (Suppl B): B12-8.
  • 16. CONSENSUS Trial Study Group: effects enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Group (CONSENSUS) N Engl J Med 1987;316:1429-35.
  • 17. Cody RJ. Management of refractory heart failure. Am J Cardiol 1992;4:141G-9G.
  • 18. Pitt B. Use of “Xapril” in patients with chronic heart failure: a paradigm of epitaph for our times? Circulation 1994;90:1550-1.
  • 19. Gheorghiade M, Bonow RO. Chronic heart failure in the US: a manifestation of coronary artery disease. Circulation 1998;97:282-9
  • 20. Greenberg B, Quinones MA, Koilpillai C, et al. Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Results of the SOLVD Echocardiography substudy. Circulation 1995;91:2573-81.
  • 21. Baker KM, Aceto JF. Angiotensin II stimulation of protein synthesis and growth in chick heart cells. Am J Physiol 1990;259:H610-H8.
  • 22. Aceto JF, Baker KM. Angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. A Physiol Soc 1990;27:H806-13.
  • 23. Beller GA, Conroy J, Smith TW. Ischemia-induced alterations in myocardial (Na+K)-ATPase and cardiac glycoside binding. J Clin Invest 1976;57:341-50.
  • 24. McMurray J, and McDewitt DG. Treatment of heart failure in the elderly. Br Med. Bull 1990;46:202.
  • 25. Waagstein F, Bristow MR, Swedberg K, et al. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Lancet 1993;342:1441-6.
  • 26. CIBIS Investigators and Committees. A randomized trial of beta-blockade in heart failure: the Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation;1994;90:1765-73.
  • 27. Chadda K, Goldstein S, Byington R, Curb JD. Effect of propranolol after acute myocardial infarction in patients with congestive heart failure. Circulation 1986;73:503-10.
  • 28. Lechat P, Chalon S, Cucherat M, Packer M. Meta-analysis of beta-blocker therapy in heart failure. Eur Heart J 1996;17(Absract Suppl)
  • 29. Packer M, Bristow MR, Cohn JN, et al. for the US Carvedilol Heart Failure Study Group. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 1996;334:1349-55.
  • 30. Packer M, O’Connor CM, Ghali JK, et al. for the Prospective Randomized Amlodipine Survival Evaluation Study group. Effect of amlodipine of morbidity and mortality in severe chronic heart failure. N Engl J Med 1996;335:1107-14.
  • 31. Cohn JN, Ziesche SM, Loss LE, and the V-HeFT study group. Effect of felodipine on short-therm exercise and neurohormonal long-term mortality in heart failure results of V-HeFT VIII (abstr). Circulation 1995; 92(suppl I):1-143.
  • 32. Stevenson WG, Stevenson LW, Middlekauff HR, et al. Improving survival for patients with advanced heart failure: a study of 737 consecutive patients. J Am Coll Cardiol 1995;26:1417-23.
  • 33. Barilla F, Gheorghiade M, Alam M, Khaje F. Low dose dobutamine in patients with acute myocardial infarction identifies viable not contractile myocardium and predicts magnitude of improvement in wall motion abnormalities in response to coronary revascularization. Am Heart J 1991;122:1522-31.
  • 34. Heart Failure. Evaluation and care of patients with left ventricular systolic dysfunction Clinical practice guideline number II. Publication No. 94-0613. June 1994. AHCPR Publication No.94-0612. June 1994.
  • 35. Dries DL, Domanski MJ, Waclawiw MA, Gersh BJ. Effect of antithrombotic therapy on risk of sudden coronary death in patients with congestive heart failure. Am J Cardiol 1997;79:909-13.
  • 36. Al-Khadra AS, Salem DN, Rand WM, Udelson JE, Smith JJ, Konstam MA. Antiplatelet agents and survival: a cohort analysis from Studies of Left Ventricular Dysfunction (SOLVD) trial. J Am Coll Cardiol 1998;31:419-25.
  • 37. Cohn JN. Nitrates in left ventricular dysfunction and congestive heart failure Am J Cardiol 1998;81(Suppl): 54A-6A.
  • 38. Nul DR, Doval HC, Grancelli HO et al. on behalf of the GESICA-GEMA investigators. Heart rate is a marker of amiodarone mortality reduction in severe heart failure. J Am Coll Cardiol 1997;29:1199-205.
  • 39. Podrid PJ, Amiodarone reevaluation of an old drug. Ann Intern Med 1995;122:689-700.
APA ERGİN A, Eryol N, ÜNAL Ş, DELİCEO A, TOPSAKAL R, SEYFELİ E (2004). Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. , 32 - 38.
Chicago ERGİN Ali,Eryol Namık Kemal,ÜNAL Şükrü,DELİCEO Abdullah,TOPSAKAL Ramazan,SEYFELİ Ergün Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. (2004): 32 - 38.
MLA ERGİN Ali,Eryol Namık Kemal,ÜNAL Şükrü,DELİCEO Abdullah,TOPSAKAL Ramazan,SEYFELİ Ergün Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. , 2004, ss.32 - 38.
AMA ERGİN A,Eryol N,ÜNAL Ş,DELİCEO A,TOPSAKAL R,SEYFELİ E Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. . 2004; 32 - 38.
Vancouver ERGİN A,Eryol N,ÜNAL Ş,DELİCEO A,TOPSAKAL R,SEYFELİ E Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. . 2004; 32 - 38.
IEEE ERGİN A,Eryol N,ÜNAL Ş,DELİCEO A,TOPSAKAL R,SEYFELİ E "Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals." , ss.32 - 38, 2004.
ISNAD ERGİN, Ali vd. "Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals". (2004), 32-38.
APA ERGİN A, Eryol N, ÜNAL Ş, DELİCEO A, TOPSAKAL R, SEYFELİ E (2004). Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. Anadolu Kardiyoloji Dergisi, 4(1), 32 - 38.
Chicago ERGİN Ali,Eryol Namık Kemal,ÜNAL Şükrü,DELİCEO Abdullah,TOPSAKAL Ramazan,SEYFELİ Ergün Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. Anadolu Kardiyoloji Dergisi 4, no.1 (2004): 32 - 38.
MLA ERGİN Ali,Eryol Namık Kemal,ÜNAL Şükrü,DELİCEO Abdullah,TOPSAKAL Ramazan,SEYFELİ Ergün Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. Anadolu Kardiyoloji Dergisi, vol.4, no.1, 2004, ss.32 - 38.
AMA ERGİN A,Eryol N,ÜNAL Ş,DELİCEO A,TOPSAKAL R,SEYFELİ E Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. Anadolu Kardiyoloji Dergisi. 2004; 4(1): 32 - 38.
Vancouver ERGİN A,Eryol N,ÜNAL Ş,DELİCEO A,TOPSAKAL R,SEYFELİ E Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals. Anadolu Kardiyoloji Dergisi. 2004; 4(1): 32 - 38.
IEEE ERGİN A,Eryol N,ÜNAL Ş,DELİCEO A,TOPSAKAL R,SEYFELİ E "Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals." Anadolu Kardiyoloji Dergisi, 4, ss.32 - 38, 2004.
ISNAD ERGİN, Ali vd. "Epidemiological and pharmacological profile of congestive heart failure at Turkish Academic Hospitals". Anadolu Kardiyoloji Dergisi 4/1 (2004), 32-38.