Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats
Yıl: 2019 Cilt: 32 Sayı: 1 Sayfa Aralığı: 27 - 32 Metin Dili: İngilizce DOI: 10.5472/marumj.518821 İndeks Tarihi: 23-03-2021
Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats
Öz: Objective: Algan hemostatic agent (AHA) is a plant-based hemostatic agent produced in Turkey. Although, there is a great improvement in the hemostatic technologies, more effective hemostatic products are required to be produced. The aim of this study was to demonstrate the efficacy of AHA in a partial splenectomy model in rats. In addition, in this model, postoperative abdominal adhesion was evaluated.Materials and Methods: In this study 5-7 weeks old 64 rats were used. Rats were randomly divided into 8 groups, each consisting of eight rats (4 groups heparinized and 4 groups non-heparinized). Experimental splenectomy was performed and the gauze impregnated with saline was applied to the control group for the hemorrhage control, the gauze impregnated with liquid AHA, gel and powder form of AHA, was applied to the experimental groups.Results: The time to reach complete homeostasis was significantly shorter in all AHA groups compared to the control group. The powder and the gel forms of AHA stopped the bleeding in heparinized and non-heparinized groups in 1 second. The AHA fluid (sponge) form stopped the bleeding in the first application in the control group less than 10 seconds and the second time application was not necessary. The bleeding was able to be controlled in the heparinized control group (saline impregnated sponge) by 55 seconds and in the non-heparinized control group by 38 seconds.Conclusion: This study showed that AHA is a highly effective hemostatic agent, which would be beneficial in controlling hemorrhage.
Anahtar Kelime: Deneysel parsiyel splenektomi modelinde sıçanlarda algan hemostatik ajanın kanama kontrolünde etkinliğinin araştırılması
Öz: Amaç: Algan hemostatik ajan (AHA), Türkiye’de üretilen bitki bazlı hemostatik bir maddedir. Hemostatik teknolojilerdeki büyük gelişmelere rağmen, kanamanın kontrolünde kullanılmak üzere daha etkili hemostatik ürünlerin üretilmesi gerekmektedir. Bu çalışmanın amacı, AHA’nın sıçanlarda parsiyel splenektomi modelindeki etkinliğini göstermektir. Ayrıca bu modelde batın yapışıklığı değerlendirilmiştir. Gereçler ve Yöntemler: Bu çalışmada 5-7 haftalık 64 sıçan kullanıldı. Sıçanların her biri sekiz sıçandan oluşan 8 gruba ayrıldı (heparinize edilmiş 4 grup ve heparinize edilmemiş 4 grup). Deneysel splenektomi yapıldı ve kontrol grubuna hemoraji kontrolü için serum fizyolojik emdirilmiş gazlı bez uygulandı, deney gruplarına AHA sıvı emdirilmiş gazlı bez, jel ve toz formu uygulandı. Bulgular: Komple hemostaza ulaşma süresi, tüm AHA gruplarında kontrol grubuna kıyasla anlamlı olarak daha kısa idi. AHA’nın toz ve jel formları heparinize ve heparinize olmayan gruplarda 1 saniyede kanamayı durdurdu. AHA sıvı (sünger) formu, kontrol grubunda ilk uygulamada tüm sıçanlarda kanamayı durdurdu (10 saniyenin altında). Kanama, heparinize edilmiş kontrol grubunda (serum fizyolojik emdirilmiş gazlı bez) ortalama 55 saniyede ve heparinize olmayan kontrol grubunda 38 saniyede kontrol edilebildi. Sonuç: Bu çalışma, AHA’nın hemorajinin kontrol edilmesinde yararlı olabilecek oldukça etkili bir hemostatik ajan olduğunu göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Midi A, EKİCİ H, KUMANDAŞ A, DURMUŞ Ö, BODİÇ B, TİRYAKİ M, balık m, YEŞİLADA E (2019). Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. , 27 - 32. 10.5472/marumj.518821 |
| Chicago | Midi Ahmet,EKİCİ Hüsamettin,KUMANDAŞ ALİ,DURMUŞ Ömercan,BODİÇ Buse,TİRYAKİ Mehmet Zahit,balık mehmet sabri,YEŞİLADA Erdem Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. (2019): 27 - 32. 10.5472/marumj.518821 |
| MLA | Midi Ahmet,EKİCİ Hüsamettin,KUMANDAŞ ALİ,DURMUŞ Ömercan,BODİÇ Buse,TİRYAKİ Mehmet Zahit,balık mehmet sabri,YEŞİLADA Erdem Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. , 2019, ss.27 - 32. 10.5472/marumj.518821 |
| AMA | Midi A,EKİCİ H,KUMANDAŞ A,DURMUŞ Ö,BODİÇ B,TİRYAKİ M,balık m,YEŞİLADA E Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. . 2019; 27 - 32. 10.5472/marumj.518821 |
| Vancouver | Midi A,EKİCİ H,KUMANDAŞ A,DURMUŞ Ö,BODİÇ B,TİRYAKİ M,balık m,YEŞİLADA E Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. . 2019; 27 - 32. 10.5472/marumj.518821 |
| IEEE | Midi A,EKİCİ H,KUMANDAŞ A,DURMUŞ Ö,BODİÇ B,TİRYAKİ M,balık m,YEŞİLADA E "Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats." , ss.27 - 32, 2019. 10.5472/marumj.518821 |
| ISNAD | Midi, Ahmet vd. "Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats". (2019), 27-32. https://doi.org/10.5472/marumj.518821 |
| APA | Midi A, EKİCİ H, KUMANDAŞ A, DURMUŞ Ö, BODİÇ B, TİRYAKİ M, balık m, YEŞİLADA E (2019). Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Medical Journal, 32(1), 27 - 32. 10.5472/marumj.518821 |
| Chicago | Midi Ahmet,EKİCİ Hüsamettin,KUMANDAŞ ALİ,DURMUŞ Ömercan,BODİÇ Buse,TİRYAKİ Mehmet Zahit,balık mehmet sabri,YEŞİLADA Erdem Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Medical Journal 32, no.1 (2019): 27 - 32. 10.5472/marumj.518821 |
| MLA | Midi Ahmet,EKİCİ Hüsamettin,KUMANDAŞ ALİ,DURMUŞ Ömercan,BODİÇ Buse,TİRYAKİ Mehmet Zahit,balık mehmet sabri,YEŞİLADA Erdem Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Medical Journal, vol.32, no.1, 2019, ss.27 - 32. 10.5472/marumj.518821 |
| AMA | Midi A,EKİCİ H,KUMANDAŞ A,DURMUŞ Ö,BODİÇ B,TİRYAKİ M,balık m,YEŞİLADA E Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Medical Journal. 2019; 32(1): 27 - 32. 10.5472/marumj.518821 |
| Vancouver | Midi A,EKİCİ H,KUMANDAŞ A,DURMUŞ Ö,BODİÇ B,TİRYAKİ M,balık m,YEŞİLADA E Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Medical Journal. 2019; 32(1): 27 - 32. 10.5472/marumj.518821 |
| IEEE | Midi A,EKİCİ H,KUMANDAŞ A,DURMUŞ Ö,BODİÇ B,TİRYAKİ M,balık m,YEŞİLADA E "Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats." Marmara Medical Journal, 32, ss.27 - 32, 2019. 10.5472/marumj.518821 |
| ISNAD | Midi, Ahmet vd. "Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats". Marmara Medical Journal 32/1 (2019), 27-32. https://doi.org/10.5472/marumj.518821 |
