The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients
Yıl: 2019 Cilt: 41 Sayı: 3 Sayfa Aralığı: 203 - 207 Metin Dili: İngilizce DOI: 10.20515/otd.410269 İndeks Tarihi: 31-03-2021
The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients
Öz: Reverse dipper hypertension and neutrophil to lymphocyte ratio (NLR) has been investigated as a predictor for cardiovascular risk. The relationship between NLR and other circadien blood pressure (BP) patterns has been showed. The aim of this study was to investigate the relation between NLR and BP reverse dipper pattern in patients with hypertension. 144 hypertensive patients (66 males, 78 females) were enrolled the study. BP patterns were evaluated with 24-h ambulatory BP monitoring (ABPM). Baseline NLR was measured by dividing neutrophil count to lymhocyte count. There was significantly increased NLR in reverse dippers (2,36±1,68 ) than dippers (1,81±0,69) of hypertension (p=0,040 ). NLR was negatively correlated with the decline rate of nocturnal systolic BP(r=-0,193;p=0.021) and diastolic BP( r=-0,160; p=0,057). Our study provides a possible association between NLR and reverse dipper pattern, but to report NLR as an independent predictor of reverse dipper pattern further studies are required.
Anahtar Kelime: Hipertansif Hastalarda Reverse-dipper Kan Basıncı ile Nötrofil Lenfosit Oranı Arasındaki İlişki
Öz: Revers dipper hipertansiyon ve nötrofil/lenfosit oranı (NLR), kardiyovasküler risk öngördürücüsü olarak araştırılmaktadır. NLR ve diğer sirkadyen kan basıncı paternleri arasındaki ilişki gösterilmiştir. Bu çalışmanın amacı hipertansif hastalarda nötrofil lenfosit oranı ile revers dipper kan basıncı paterni arasındaki ilişkiyi değerlendirmektir. Çalışmaya 144 (66 erkek, 78 kadın) hipertansif hasta alındı. Kan basıncı paternleri 24 saat ambulatuar kan basıncı ile değerlendirildi. Nötrofil lenfosit oranı, nötrofil sayısı lenfosit sayısına bölünerek ölçüldü. Revers dipper hipertansiyonlularda dipper hipertansiyonlulara göre nötrofil lenfosit oranında anlamlı artış vardı. (sırasıyla 2.36±1,68 ve 1,81±0,69, p=0,040 ). Nötrofil lenfosit oranı ile sistolik (r=-0,193;p=0.021 ve diyastolik ( r=-0,160; p=0,057) kan basıncı düşme oranları arasında negatif korelasyon vardı. Çalışmamız NLR ve revers dipper patern arasında olası bir ilişki sunmaktadır ancak nötrofil lenfosit oranını, revers dipper paternin bağımsız öngörücüsü olarak rapor etmek için daha ileri çalışmalar gereklidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Pickering TG, Shimbo D, Haas D. Ambulatory blood-pressure monitoring. N Engl J Med. 2006;354:2368-2374. doi:10.1056/NEJMra060433. PubMed PMID: 16738273.
- 2. McAlister FA, Straus SE. Evidence based treatment of hypertension. Measurement of blood pressure : an evidence based review. BMJ 2001; 322:908-11. PubMed PMID: 11302909.
- 3. Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Gattobigio R, Guerrieri M, et al. Altered circadian blood pressure profile and prognosis. PubMed PMID:10234138.
- 4. Ohkubo T, Imai Y, Tsuji I, Nagai K,Watanabe N, Minami N, et al. Relation between nocturnal decline in blood pressure and mortality. The Ohasama Study. Am J Hypertens.1997;10:1201-1207. PubMed PMID: 9397237.
- 5. Yan B, Peng L, Han D, Sun L, Dong Q, Yang P, et al. Reverse –dipper pattern of blood pressure may predict lacunar infarction in patients with essential hypertension. Eur J Neurol 2015;22:1022-5. doi: 10.1111/ene.12659. PubMed PMID: 25614275. Epub 2015 Jan 23.
- 6. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymhocyte ratio and outcomes in patients with acute coranary syndrome. Am J Cardiol 2008;102:653-7. doi: 10.1016/j.amjcard.2008.05.006. PubMed PMID:18773982. Epub 2008 Jun 26.
- 7. Turak O, Ozcan F, Tok D, Işleyen A, Sökmen E, Taşoğlu I. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich) 2013;15:7-13. doi: 10.1111/jch.12026. Epub 2012 Nov 2. PubMed PMID: 23282120.
- 8. Verdecchia P, Porcellati C, Schillaci G, Borgioni C, Ciucci A, Battistelli M, et al. Ambulatory blood pressure. an independent predictor of prognosis in essential hypertension. Hypertension. 1994;24:793-801. PubMed PMID: 7995639.
- 9. Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, Ohmori K, Michimata M, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens 2002;20:2183-9. PubMed PMID: 12409956.
- 10. Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, et al. Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet 2007;370:1219-29.doi:10.1016/S0140- 6736(07)61538-4. PubMed PMID: 17920917.
- 11. Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K.. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension 38, 852-857 (2001). PubMed PMID: 11641298.
- 12. Yan B, Peng L, Han D, Sun L, Dong Q, Yang P et al. Blood pressure reverse-dipping is associated with early formation of carotid plaque in senior hypertensive patients. Medicine (Baltimore) 2015; 94:e604. doi: 10.1097/MD.0000000000000604. PubMed PMID:25761180.
- 13. WangC,YeZ,LiY,ZhangJ,ZhangQ,MaX et al. Prognostic value of reverse dipper blood pressure pattern in chronic kidney disease patients not undergoing dialysis: Prospective cohort study. Sci Rep.2016; 6: 34932. doi: 10.1038/srep34932. PubMed PMID: 27713498.
- 14. SuD,GuoQ,GaoY, HanJ,YanB,PengL, et al. The relationship between red blood cell distribution width and blood pressure abnormal dispping in patients with essential hypertension: a cross-sectional study. BMJ Open 2016;6:e010456. doi: 10.1136/bmjopen- 2015-010456. PMID:26908530.
| APA | tek öztürk m, AYERDEN EBİNÇ F, aybal kutlugun a, KAPLAN EFE F, ÇETİN M, ÇELEBİ S, Berkalp B (2019). The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. , 203 - 207. 10.20515/otd.410269 |
| Chicago | tek öztürk mujgan,AYERDEN EBİNÇ FATMA,aybal kutlugun aysun,KAPLAN EFE FATMA,ÇETİN Mehmet Serkan,ÇELEBİ Sevaş,Berkalp Berkten The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. (2019): 203 - 207. 10.20515/otd.410269 |
| MLA | tek öztürk mujgan,AYERDEN EBİNÇ FATMA,aybal kutlugun aysun,KAPLAN EFE FATMA,ÇETİN Mehmet Serkan,ÇELEBİ Sevaş,Berkalp Berkten The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. , 2019, ss.203 - 207. 10.20515/otd.410269 |
| AMA | tek öztürk m,AYERDEN EBİNÇ F,aybal kutlugun a,KAPLAN EFE F,ÇETİN M,ÇELEBİ S,Berkalp B The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. . 2019; 203 - 207. 10.20515/otd.410269 |
| Vancouver | tek öztürk m,AYERDEN EBİNÇ F,aybal kutlugun a,KAPLAN EFE F,ÇETİN M,ÇELEBİ S,Berkalp B The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. . 2019; 203 - 207. 10.20515/otd.410269 |
| IEEE | tek öztürk m,AYERDEN EBİNÇ F,aybal kutlugun a,KAPLAN EFE F,ÇETİN M,ÇELEBİ S,Berkalp B "The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients." , ss.203 - 207, 2019. 10.20515/otd.410269 |
| ISNAD | tek öztürk, mujgan vd. "The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients". (2019), 203-207. https://doi.org/10.20515/otd.410269 |
| APA | tek öztürk m, AYERDEN EBİNÇ F, aybal kutlugun a, KAPLAN EFE F, ÇETİN M, ÇELEBİ S, Berkalp B (2019). The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. Osmangazi Tıp Dergisi, 41(3), 203 - 207. 10.20515/otd.410269 |
| Chicago | tek öztürk mujgan,AYERDEN EBİNÇ FATMA,aybal kutlugun aysun,KAPLAN EFE FATMA,ÇETİN Mehmet Serkan,ÇELEBİ Sevaş,Berkalp Berkten The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. Osmangazi Tıp Dergisi 41, no.3 (2019): 203 - 207. 10.20515/otd.410269 |
| MLA | tek öztürk mujgan,AYERDEN EBİNÇ FATMA,aybal kutlugun aysun,KAPLAN EFE FATMA,ÇETİN Mehmet Serkan,ÇELEBİ Sevaş,Berkalp Berkten The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. Osmangazi Tıp Dergisi, vol.41, no.3, 2019, ss.203 - 207. 10.20515/otd.410269 |
| AMA | tek öztürk m,AYERDEN EBİNÇ F,aybal kutlugun a,KAPLAN EFE F,ÇETİN M,ÇELEBİ S,Berkalp B The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. Osmangazi Tıp Dergisi. 2019; 41(3): 203 - 207. 10.20515/otd.410269 |
| Vancouver | tek öztürk m,AYERDEN EBİNÇ F,aybal kutlugun a,KAPLAN EFE F,ÇETİN M,ÇELEBİ S,Berkalp B The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. Osmangazi Tıp Dergisi. 2019; 41(3): 203 - 207. 10.20515/otd.410269 |
| IEEE | tek öztürk m,AYERDEN EBİNÇ F,aybal kutlugun a,KAPLAN EFE F,ÇETİN M,ÇELEBİ S,Berkalp B "The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients." Osmangazi Tıp Dergisi, 41, ss.203 - 207, 2019. 10.20515/otd.410269 |
| ISNAD | tek öztürk, mujgan vd. "The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients". Osmangazi Tıp Dergisi 41/3 (2019), 203-207. https://doi.org/10.20515/otd.410269 |
