Apelinerjik Sistem ve Miyokardiyal Kontraktilite

Isbil Buyukcoskun, Naciye; Sahinturk, Serdar

doi:https://doi.org/10.32708/uutfd.697633

Apelinerjik Sistem ve Miyokardiyal Kontraktilite

Serdar ŞAHİNTÜR, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Bursa, Türkiye)

Naciye İŞBİL (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Bursa, Türkiye)

Uludağ Üniversitesi Tıp Fakültesi Dergisi

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Yıl: 2020 Cilt: 46 Sayı: 1 Sayfa Aralığı: 129 - 134 Metin Dili: Türkçe DOI: https://doi.org/10.32708/uutfd.697633 İndeks Tarihi: 30-04-2021

Apelinerjik Sistem ve Miyokardiyal Kontraktilite

Öz:

Apelinerjik sistem APJ (apelin reseptörü), apelin ve elabeladan oluşmaktadır. APJ, G protein kenetli bir reseptördür. Apelin ve elabelaAPJ’nin endojen ligandlarıdır. APJ, apelin ve elabela kardiyovasküler dokularda yaygın olarak eksprese edilmektedir. Vazodilatatör, kardiyoprotektif ve anjiyogenik etkilere aracılık eden apelin ve elabelanın pozitif inotropik etkisi oldukça güçlüdür. Apelinin pozitif inotropiketkisinde fosfolipaz C aktivasyonu sonrası kalsiyum bağımlı ve kalsiyum bağımsız mekanizmaların rol oynadığı ileri sürülmektedir. Elabelanın ise mitojenle aktiflenen protein kinaz 1/2-ekstraselüler sinyalle düzenlenen kinaz 1/2 yolağını aktive ederek pozitif inotropik etki gösterdiği düşünülmektedir. Apelin, elabela, bunların analogları ve APJ agonistleri güçlü pozitif inotropik etkileri nedeni ile kalp yetmezliği tedavisinde önemli bir tedavi alternatifi oluşturabilir. Bu derlemede apelinerjik sistemin miyokard fonksiyonuna etkileri ve etki mekanizmalarıüzerinde durulmaktadır.

Anahtar Kelime:

Öz:

The apelinergic system consists of APJ (apelin receptor), apelin and elabela. APJ is a G protein-coupled receptor. Apelin and elabela are endogenous ligands of APJ. APJ, apelin and elabela are widely expressed in cardiovascular tissues. The positive inotropic effect of apelin and elabela, which mediate vasodilator, cardioprotective and angiogenic effects, is quite potent. It is suggested that calcium-dependent and calcium-independent mechanisms play role in the positive inotropic effect of apelin after activation of phospholipase C. Elabela is thought to show positive inotropic effect by activating mitogen-activated protein kinase 1/2-extracellular signal-regulated kinase 1/2 pathway. Apelin, elabela, their analogues and APJ agonists may be an important alternative in the treatment of heart failure due to their potent positive inotropic effects. This review focuses on effects and effect mechanisms of the apelinergic system on myocardial function

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Sahinturk S, Isbil Buyukcoskun N (2020). Apelinerjik Sistem ve Miyokardiyal Kontraktilite. , 129 - 134. https://doi.org/10.32708/uutfd.697633
Chicago	Sahinturk Serdar,Isbil Buyukcoskun Naciye Apelinerjik Sistem ve Miyokardiyal Kontraktilite. (2020): 129 - 134. https://doi.org/10.32708/uutfd.697633
MLA	Sahinturk Serdar,Isbil Buyukcoskun Naciye Apelinerjik Sistem ve Miyokardiyal Kontraktilite. , 2020, ss.129 - 134. https://doi.org/10.32708/uutfd.697633
AMA	Sahinturk S,Isbil Buyukcoskun N Apelinerjik Sistem ve Miyokardiyal Kontraktilite. . 2020; 129 - 134. https://doi.org/10.32708/uutfd.697633
Vancouver	Sahinturk S,Isbil Buyukcoskun N Apelinerjik Sistem ve Miyokardiyal Kontraktilite. . 2020; 129 - 134. https://doi.org/10.32708/uutfd.697633
IEEE	Sahinturk S,Isbil Buyukcoskun N "Apelinerjik Sistem ve Miyokardiyal Kontraktilite." , ss.129 - 134, 2020. https://doi.org/10.32708/uutfd.697633
ISNAD	Sahinturk, Serdar - Isbil Buyukcoskun, Naciye. "Apelinerjik Sistem ve Miyokardiyal Kontraktilite". (2020), 129-134. https://doi.org/https://doi.org/10.32708/uutfd.697633

APA	Sahinturk S, Isbil Buyukcoskun N (2020). Apelinerjik Sistem ve Miyokardiyal Kontraktilite. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(1), 129 - 134. https://doi.org/10.32708/uutfd.697633
Chicago	Sahinturk Serdar,Isbil Buyukcoskun Naciye Apelinerjik Sistem ve Miyokardiyal Kontraktilite. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, no.1 (2020): 129 - 134. https://doi.org/10.32708/uutfd.697633
MLA	Sahinturk Serdar,Isbil Buyukcoskun Naciye Apelinerjik Sistem ve Miyokardiyal Kontraktilite. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol.46, no.1, 2020, ss.129 - 134. https://doi.org/10.32708/uutfd.697633
AMA	Sahinturk S,Isbil Buyukcoskun N Apelinerjik Sistem ve Miyokardiyal Kontraktilite. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2020; 46(1): 129 - 134. https://doi.org/10.32708/uutfd.697633
Vancouver	Sahinturk S,Isbil Buyukcoskun N Apelinerjik Sistem ve Miyokardiyal Kontraktilite. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2020; 46(1): 129 - 134. https://doi.org/10.32708/uutfd.697633
IEEE	Sahinturk S,Isbil Buyukcoskun N "Apelinerjik Sistem ve Miyokardiyal Kontraktilite." Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46, ss.129 - 134, 2020. https://doi.org/10.32708/uutfd.697633
ISNAD	Sahinturk, Serdar - Isbil Buyukcoskun, Naciye. "Apelinerjik Sistem ve Miyokardiyal Kontraktilite". Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/1 (2020), 129-134. https://doi.org/https://doi.org/10.32708/uutfd.697633