Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant

Jara-Aguilar, Demetrio; Benites, Julio; Ríos, David; Quispe Diaz, Ivan Miguel; Ybañez-Julca, Roberto Osmundo; Enríquez, Cinthya; Buc Calderon, Pedro; Zavala Urtecho, Ewaldo Debray; Guerrero-Castilla, Angelica

Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant

Julio Benites, (Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile)

David R OS, (Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile)

Angelica GUERRERO-CASTİLLA, (Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile)

Cinthya ENR QUEZ, (Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile)

Ewaldo Zavala, (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, 13011 Trujillo, Perú)

Roberto O. YBANEZ-JULCA, (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, 13011 Trujillo, Perú)

Ivan QUİSPE-D AZ, (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, 13011 Trujillo, Perú)

Rafael Jara-Aguilar, (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, 13011 Trujillo, Perú)

Pedro Buc Calderon (Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile)

Records of Natural Products

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Yıl: 2021 Cilt: 15 Sayı: 3 Sayfa Aralığı: 175 - 186 Metin Dili: İngilizce İndeks Tarihi: 01-05-2021

Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant

Öz:

Clinopodium sericeum is widely used in Peruvian folk medicine in the form of infusion to treat stomach distress, indigestion and antiflu. In this study, the essential oil from C. sericeum was obtained by hydrodistillation, analyzed by GC and GC/MS, and 73 compounds were identified. Major components of the oil were -germacrene-D (15%), -caryophyllene (13.8%), and sabinene (11.2%). Furthermore, we assessed the in vitro biological activities displayed by the oil obtained from the aerial parts of C. sericeum, namely the antioxidant, antimicrobial and antiproliferative activities. The antioxidant activities of the essential oil were evaluated by FRAP, CUPRAC, ABTS and DPPH radical scavenging activity. The essential oil displays antibacterial activity against Gram-negative and Gram-positive bacterial strains (MIC 50-200 µg/mL) in a dose-range close to standard antibiotics. Such activity may be related to the presence of terpene compounds. The antiproliferative activity of the essential oil was measured in vitro using the MTT colorimetric assay in healthy non-tumorigenic cells (HEK-293) and in three human cancer cell lines (T24, DU-145, and MCF-7). The calculated IC50 values were around 0.2 mg/mL. Since the essential oil was almost devoid of antioxidant activity, its anti-proliferative action is unlikely related to oxidative stress and relies on other unknown mechanisms.

Anahtar Kelime: Folk medicine Clinopodium sericeum antioxidant antimicrobial antiproliferative cancer cells

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Benites J, Ríos D, Guerrero-Castilla A, Enríquez C, Zavala Urtecho E, Ybañez-Julca R, Quispe Diaz I, Jara-Aguilar D, Buc Calderon P (2021). Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. , 175 - 186.
Chicago	Benites Julio,Ríos David,Guerrero-Castilla Angelica,Enríquez Cinthya,Zavala Urtecho Ewaldo Debray,Ybañez-Julca Roberto Osmundo,Quispe Diaz Ivan Miguel,Jara-Aguilar Demetrio,Buc Calderon Pedro Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. (2021): 175 - 186.
MLA	Benites Julio,Ríos David,Guerrero-Castilla Angelica,Enríquez Cinthya,Zavala Urtecho Ewaldo Debray,Ybañez-Julca Roberto Osmundo,Quispe Diaz Ivan Miguel,Jara-Aguilar Demetrio,Buc Calderon Pedro Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. , 2021, ss.175 - 186.
AMA	Benites J,Ríos D,Guerrero-Castilla A,Enríquez C,Zavala Urtecho E,Ybañez-Julca R,Quispe Diaz I,Jara-Aguilar D,Buc Calderon P Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. . 2021; 175 - 186.
Vancouver	Benites J,Ríos D,Guerrero-Castilla A,Enríquez C,Zavala Urtecho E,Ybañez-Julca R,Quispe Diaz I,Jara-Aguilar D,Buc Calderon P Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. . 2021; 175 - 186.
IEEE	Benites J,Ríos D,Guerrero-Castilla A,Enríquez C,Zavala Urtecho E,Ybañez-Julca R,Quispe Diaz I,Jara-Aguilar D,Buc Calderon P "Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant." , ss.175 - 186, 2021.
ISNAD	Benites, Julio vd. "Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant". (2021), 175-186.

APA	Benites J, Ríos D, Guerrero-Castilla A, Enríquez C, Zavala Urtecho E, Ybañez-Julca R, Quispe Diaz I, Jara-Aguilar D, Buc Calderon P (2021). Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. Records of Natural Products, 15(3), 175 - 186.
Chicago	Benites Julio,Ríos David,Guerrero-Castilla Angelica,Enríquez Cinthya,Zavala Urtecho Ewaldo Debray,Ybañez-Julca Roberto Osmundo,Quispe Diaz Ivan Miguel,Jara-Aguilar Demetrio,Buc Calderon Pedro Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. Records of Natural Products 15, no.3 (2021): 175 - 186.
MLA	Benites Julio,Ríos David,Guerrero-Castilla Angelica,Enríquez Cinthya,Zavala Urtecho Ewaldo Debray,Ybañez-Julca Roberto Osmundo,Quispe Diaz Ivan Miguel,Jara-Aguilar Demetrio,Buc Calderon Pedro Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. Records of Natural Products, vol.15, no.3, 2021, ss.175 - 186.
AMA	Benites J,Ríos D,Guerrero-Castilla A,Enríquez C,Zavala Urtecho E,Ybañez-Julca R,Quispe Diaz I,Jara-Aguilar D,Buc Calderon P Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. Records of Natural Products. 2021; 15(3): 175 - 186.
Vancouver	Benites J,Ríos D,Guerrero-Castilla A,Enríquez C,Zavala Urtecho E,Ybañez-Julca R,Quispe Diaz I,Jara-Aguilar D,Buc Calderon P Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant. Records of Natural Products. 2021; 15(3): 175 - 186.
IEEE	Benites J,Ríos D,Guerrero-Castilla A,Enríquez C,Zavala Urtecho E,Ybañez-Julca R,Quispe Diaz I,Jara-Aguilar D,Buc Calderon P "Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant." Records of Natural Products, 15, ss.175 - 186, 2021.
ISNAD	Benites, Julio vd. "Chemical Composition and Assessment of Antimicrobial,Antioxidant and Antiproliferative Activities of Essential oil fromClinopodium sericeum, a Peruvian Medicinal Plant". Records of Natural Products 15/3 (2021), 175-186.