The Effects of Taurine on Central Nervous System

Taurine is a neuroprotective amino acid which regulates gene expression of neural stem and precursor cells, modulating inflammatory pathways in the central nervous system, suppressing apoptosis, antioxidant effect and controlling cell volume and water content of neurons. Taurine suppresses endoplasmic stress-mediated apoptosis through the ionotropic taurine receptor and the metabotropic taurine receptor. Due to its neuroprotective effect, taurine is successfullyused in the prophylaxis and treatment of neurodegenerative disorders. This review aims to present current scientific information of the effects of taurine on the central nervous system and its use in alleviating central nervous system disorders.

Anahtar Kelime:

Investigation of Os Coxae in Horses Using Geometric Morphometry Method

Öz:

In contrast to normal morphometric measurements, geometric morphometry is a method that can explain the differences and variations on the x-y coordinates of the specified points on a 2D plane. In this method, two-dimensional samples, such as pictures or x-rays, are used. The study aims to investigate the right os coxae of 23 adults (12 males, 11 females) horses geometrically. Photographs were taken from each sample at 120 centimeters distance and landmarks were made on these samples. 13 determining landmarks were used on os coxae. Medial endpoint of the narrowest section of the body of ilium and medial endpoint of ischial spine points were found to be statistically significant in terms of female and male distinction (P < 0.001). It was seen that the remaining points in the ventrolateral section did not have a statistically significant difference in gender discrimination. However, the difference between the genders in the ventral endpoint of coxal tuber and midpoint of coxal tuber in the dorsolateral section was statistically significant (P < 0.001). The difference between females and males is visually indicated using the morphology program. In females, it was observed that the points in the inner region are more lateral than males. Gender analysis studies can be conducted on materials such as bone using the morphometric results obtained as a result of such modeling studies.

Anahtar Kelime:

Geometrik Morfometri Yöntemi Kullanılarak Atlarda Os Coxae’larının İncelenmesi

Öz:

Geometrik morfometri, normal morfometrik ölçümlerin aksine 2D düzlemde belirtilen noktaların x-ykoordinatlarındaki farklılıkları ve varyasyonları açıklayan bir yöntemdir. Resim veya röntgen gibi iki boyutlu örneklerkullanılır. Bu çalışmada erişkin 23 (12 erkek, 11 dişi) tane atın sağ os coxae’sı geometrik olarak incelenmesi amaçlanmıştır.Her örnekten 120 santimetre uzaklıktan fotoğraflar alınmış ve bu örnekler üzerinden işaretlemeler yapılmıştır. Os coxaeüzerinde 13 adet belirleyici nokta kullanılmıştır. Cinsiyet ayırımı bakımından, spina ischiadica’nın orta noktası ve iliumgövdesinin en dar bölümünün medial uç noktası arasında istatistiksel olarak anlamlı bir fark bulunmuştur (P < 0.001).Ventrolateral bölümde kalan noktaların cinsiyet ayrımında istatistiksel olarak anlamlı bir fark göstermediği görülmedi.Bununla birlikte, cinsiyetler arasında tuber coxae’nın ventral son noktası ve dorsolateral bölümünün orta noktası istatistikselolarak anlamlıydı (P < 0.001). Dişi ve erkekler arasındaki fark, morfoloji programı kullanılarak gösterildi. Dişilerde içbölgedeki noktalar erkeklere göre daha yanal olduğu gözlemlendi. Bu modelleme çalışmaları sonucunda elde edilenmorfometrik sonuçlar kullanılarak kemik gibi materyaller üzerinde cinsiyet analizi çalışmaları yapılabilmektedir.

Anahtar Kelime:

Taurinin Merkezi Sinir Sistemi Üzerindeki Etkileri

Öz:

Taurin, nöral kök ve prekürsör hücrelerin gen ekspresyonunu düzenleyen, merkezi sinir sistemindeki enflamatuaryolları modüle eden, apoptozu baskılayan, antioksidan etkili ve nöronların hacmini ve su içeriğini kontrol eden nöroprotektif bir amino asittir. Taurin, iyonotropik taurin reseptörü ve metabotropik taurin reseptörü aracılığıyla endoplazmik stres aracılıapoptozu baskılamaktadır. Nöroprotektif etkisi nedeniyle taurin nörodejeneratif bozuklukların profilaksisinde ve tedavisindebaşarıyla kullanılmaktadır. Bu derlemenin amacı, taurinin merkezi sinir sistemi üzerindeki etkilerini ve taurinin merkezi sinirsistemi hasarlarını hafifletmede kullanımını konusunda güncel bilimsel bilgiyi sunmaktır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Salt A, Gündemir O, YARIM G, Ozkan E, YARIM M, İNCE N, PAZVANT G, DEMIRCIOGLU I, AYDOĞDU S, KOÇYİĞİT A, Dayan M (2020). The Effects of Taurine on Central Nervous System. , 214 - 219. 10.31196/huvfd.751318
Chicago	Salt Ayris,Gündemir Ozan,YARIM Gül Fatma,Ozkan Ermis,YARIM Murat,İNCE Nazan GEZER,PAZVANT GÜLSÜN,DEMIRCIOGLU ISMAIL,AYDOĞDU Sedat,KOÇYİĞİT Ali,Dayan Mustafa Orhun The Effects of Taurine on Central Nervous System. (2020): 214 - 219. 10.31196/huvfd.751318
MLA	Salt Ayris,Gündemir Ozan,YARIM Gül Fatma,Ozkan Ermis,YARIM Murat,İNCE Nazan GEZER,PAZVANT GÜLSÜN,DEMIRCIOGLU ISMAIL,AYDOĞDU Sedat,KOÇYİĞİT Ali,Dayan Mustafa Orhun The Effects of Taurine on Central Nervous System. , 2020, ss.214 - 219. 10.31196/huvfd.751318
AMA	Salt A,Gündemir O,YARIM G,Ozkan E,YARIM M,İNCE N,PAZVANT G,DEMIRCIOGLU I,AYDOĞDU S,KOÇYİĞİT A,Dayan M The Effects of Taurine on Central Nervous System. . 2020; 214 - 219. 10.31196/huvfd.751318
Vancouver	Salt A,Gündemir O,YARIM G,Ozkan E,YARIM M,İNCE N,PAZVANT G,DEMIRCIOGLU I,AYDOĞDU S,KOÇYİĞİT A,Dayan M The Effects of Taurine on Central Nervous System. . 2020; 214 - 219. 10.31196/huvfd.751318
IEEE	Salt A,Gündemir O,YARIM G,Ozkan E,YARIM M,İNCE N,PAZVANT G,DEMIRCIOGLU I,AYDOĞDU S,KOÇYİĞİT A,Dayan M "The Effects of Taurine on Central Nervous System." , ss.214 - 219, 2020. 10.31196/huvfd.751318
ISNAD	Salt, Ayris vd. "The Effects of Taurine on Central Nervous System". (2020), 214-219. https://doi.org/10.31196/huvfd.751318

APA	Salt A, Gündemir O, YARIM G, Ozkan E, YARIM M, İNCE N, PAZVANT G, DEMIRCIOGLU I, AYDOĞDU S, KOÇYİĞİT A, Dayan M (2020). The Effects of Taurine on Central Nervous System. Harran Üniversitesi Veteriner Fakültesi Dergisi, 9(2), 214 - 219. 10.31196/huvfd.751318
Chicago	Salt Ayris,Gündemir Ozan,YARIM Gül Fatma,Ozkan Ermis,YARIM Murat,İNCE Nazan GEZER,PAZVANT GÜLSÜN,DEMIRCIOGLU ISMAIL,AYDOĞDU Sedat,KOÇYİĞİT Ali,Dayan Mustafa Orhun The Effects of Taurine on Central Nervous System. Harran Üniversitesi Veteriner Fakültesi Dergisi 9, no.2 (2020): 214 - 219. 10.31196/huvfd.751318
MLA	Salt Ayris,Gündemir Ozan,YARIM Gül Fatma,Ozkan Ermis,YARIM Murat,İNCE Nazan GEZER,PAZVANT GÜLSÜN,DEMIRCIOGLU ISMAIL,AYDOĞDU Sedat,KOÇYİĞİT Ali,Dayan Mustafa Orhun The Effects of Taurine on Central Nervous System. Harran Üniversitesi Veteriner Fakültesi Dergisi, vol.9, no.2, 2020, ss.214 - 219. 10.31196/huvfd.751318
AMA	Salt A,Gündemir O,YARIM G,Ozkan E,YARIM M,İNCE N,PAZVANT G,DEMIRCIOGLU I,AYDOĞDU S,KOÇYİĞİT A,Dayan M The Effects of Taurine on Central Nervous System. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2020; 9(2): 214 - 219. 10.31196/huvfd.751318
Vancouver	Salt A,Gündemir O,YARIM G,Ozkan E,YARIM M,İNCE N,PAZVANT G,DEMIRCIOGLU I,AYDOĞDU S,KOÇYİĞİT A,Dayan M The Effects of Taurine on Central Nervous System. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2020; 9(2): 214 - 219. 10.31196/huvfd.751318
IEEE	Salt A,Gündemir O,YARIM G,Ozkan E,YARIM M,İNCE N,PAZVANT G,DEMIRCIOGLU I,AYDOĞDU S,KOÇYİĞİT A,Dayan M "The Effects of Taurine on Central Nervous System." Harran Üniversitesi Veteriner Fakültesi Dergisi, 9, ss.214 - 219, 2020. 10.31196/huvfd.751318
ISNAD	Salt, Ayris vd. "The Effects of Taurine on Central Nervous System". Harran Üniversitesi Veteriner Fakültesi Dergisi 9/2 (2020), 214-219. https://doi.org/10.31196/huvfd.751318