TY  - JOUR
TI  - Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients
AB  - ABS TRACT Objective: Specific ABO blood group and Rh antigens are found to be associated with several malignancies and lung cancer. However, the relationship between blood type and Epidermal Growth Factor Receptor (EGFR) mutation in lung cancer remains poorly in-vestigated. Material and Methods: In this retrospective case-control study, 105 EGFR mutation-positive and 169 EGFR mutation-negative lung adenocarcinoma patients were included. Baseline characteristics of the patients were determined. Odds ratios were calculated for the re-lationship of EGFR mutation positivity according to the ABO and Rh blood type. Overall survival difference according to the blood types was analyzed in metastatic patients that were diagnosed in the EGFR-mutant group. Results: There was no statistically significant increase ob-served in the relationship of EGFR mutation positivity for any of ABO and Rh types (OR and p-value, respectively; A: 1.15-0.57, B: 0.68-0.28, AB: 1-0.98, O: 1.06-0.82, Rh: 1.04-0.91). There was no statistically significant overall survival difference between ABO types (16, 21.1, 18.9, 24.9 months for O, A, B, AB blood groups, respectively). Conclusion: No significant association between blood type and EGFR mutation positivity in lung adenocarcinoma could be established.
AU  - Hayme, Serhat
AU  - AKKUS, ERMAN
AU  - Aktaş, Elif Gizem
AU  - Özakıncı, Hilal
AU  - Gürbüz, Mustafa
AU  - Dizbay Sak, Serpil
AU  - Karaalioğlu, Bilgin
AU  - koksoy, elif berna
AU  - Demirkazik, Ahmet
AU  - utkan, gungor
AU  - ÜRÜN, YÜKSEL
DO  - 10.37047/jos.2020-79248
PY  - 2021
JO  - Journal of oncological sciences
VL  - 7
IS  - 1
SN  - 2651-4532
SP  - 20
EP  - 24
DB  - TRDizin
UR  - http://search/yayin/detay/407317
ER  -