Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study

Objectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes bethe only symptom in these patients. This retrospective and prospective study was an investigation of any differences in termsof clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) andcases with other concomitant findings (non-isolated headache [NIH]).Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis (VENOST study) were enrolled inthis research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared.Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated byage group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IHgroup, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH groupduring follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group thanin the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in theNIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group.Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an importantrole in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.

Anahtar Kelime:

Tek semptomu baş ağrısı olan serebral venöz sinüs trombozu: VENOST çalışmasından elde edilen verilerin alt grup analizi

Öz:

Amaç: Baş ağrısı serebral venöz sinüs trombozunda (SVST) en sık görülen şikayettir ve bazen CVST ile başvuran hastalarda görülen tek semptom olabilir. Bu retrospektif ve prospektif çalışmada, izole başağrısı (IB) ile başvuran SVST olgularında ve baş ağrısı ile ilişkili diğer bulguları olan (izole olmayan başağrısı-İOBA) olgularda klinik risk faktörleri, radyoloji ve prognoz açısından herhangi bir farklılık olup olmadığını araştırdık. Gereç ve Yöntem: Serebral venöz sinüs trombozu (VENOST) çok merkezli çalışmasından 1144 hasta çalışmamıza alındı. Tüm demografik, biyokimyasal, klinik ve radyolojik yönler 287 IBA vakası ve 857 İOBA vakası için karşılaştırılmıştır. Bulgular: Toplam grup içinde kadın oranı iki kat daha yüksekti. İBA grubunda cinsiyet dağılımını yaş gruplarına göre değerlendirildiğinde istatistiksel olarak anlamlı bir fark bulunmadı. İBA grubunda, baş ağrısının başlangıcı sıklıkla subakut ve kronikti, ancak akut başlangıç, İOBA grubunda daha yaygındı. İBA grubunda% 29’luk takip sırasında diğer nörolojik bulgular eklenmiştir. Daha önce serebral, derin ve diğer venöz tromboembolizm öyküsü İBA grubunda İOBA grubuna göre daha azdı. Transvers sinüs tutulumu İBA grubunda daha yüksek iken sagital sinüs tutulumu İOBA grubunda daha fazlaydı. Plazminojen aktivatör inhibitörü (PAI) mutasyonu IBA grubunda anlamlı olarak daha yüksekti. Sonuç: Hastaların subakut veya kronik baş ağrısı varsa SVST tanısı için IBA akılda tutulmalıdır. Trombolitik olaylar için önemli bir role sahip olan PAI, SVST’da bir risk faktörü olabilir, bu nedenle ayrıntılı hematolojik araştırmalar düşünülmelidir. Daha ileri çalışmalara ihtiyaç vardır

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DUMAN T, Cinar N, UGURLU D, domac f, Ozturk S, Yayla V, karahan a, Afsar N, SUNGUR M, ozaydin goksu e, Yurekli V, Genç H, UTKU U, Sahin S, TEKELI H, TOKUÇ F, Uzuner N, Şenol M, YILMAZ A, Gökçe M, DEMİRCİ S, Yilmaz Kusbeci O, TEKGÖL UZUNER G, Batur Caglayan H, AÇIKGÖZ M, KURUCU H, OZDAG M, Baybas S, Ekmekci H, Cabalar M, Yaman M, Bektaş H, kaplan y, GÖKSEL K, MİLANLIOĞLU A, Necioglu Orken D, ALUCLU M, ÇOLAKOĞLU S, TÜFEKÇİ A, Bakar M, Nazliel B, Tascilar N, Goksan B, Kozak H, mısırlı c, Küçükoğlu H, Midi I, MENGÜLLÜOĞLU N, aytac e, Yesilot N, İNCE B, Yalın O, GÜNEŞ T, ORUÇ S, Demir S (2021). Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. , 7 - 14. 10.14744/agri.2020.77698
Chicago	DUMAN Taşkın,Cinar Nilgun,UGURLU DERYA,domac fusun,Ozturk Serefnur,Yayla Vildan,karahan ali yavuz,Afsar Nazire,SUNGUR Mehmet Ali,ozaydin goksu eylem,Yurekli Vedat Ali,Genç Hamit,UTKU UYGAR,Sahin Sevki,TEKELI Hakan,TOKUÇ Firdevs Ezgi,Uzuner Nevzat,Şenol Mehmet Güney,YILMAZ ARDA,Gökçe Mustafa,DEMİRCİ Seden,Yilmaz Kusbeci Ozge,TEKGÖL UZUNER GÜLNUR,Batur Caglayan Hale,AÇIKGÖZ Mustafa,KURUCU HATICE,OZDAG Mehmet Fatih,Baybas Sevim,Ekmekci Hakan,Cabalar Murat,Yaman Mehmet,Bektaş Hesna,kaplan yuksel,GÖKSEL Karakurum Başak,MİLANLIOĞLU Aysel,Necioglu Orken Dilek,ALUCLU Mehmet Ufuk,ÇOLAKOĞLU Sena,TÜFEKÇİ AHMET,Bakar Mustafa,Nazliel Bijen,Tascilar Nida,Goksan Baki,Kozak Hasan Hüseyin,mısırlı cemile handan,Küçükoğlu Hayriye,Midi Ipek,MENGÜLLÜOĞLU Necdet,aytac emrah,Yesilot Nilufer,İNCE Birsen,Yalın Osman Özgür,GÜNEŞ TAŞKIN,ORUÇ Serdar,Demir Serkan Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. (2021): 7 - 14. 10.14744/agri.2020.77698
MLA	DUMAN Taşkın,Cinar Nilgun,UGURLU DERYA,domac fusun,Ozturk Serefnur,Yayla Vildan,karahan ali yavuz,Afsar Nazire,SUNGUR Mehmet Ali,ozaydin goksu eylem,Yurekli Vedat Ali,Genç Hamit,UTKU UYGAR,Sahin Sevki,TEKELI Hakan,TOKUÇ Firdevs Ezgi,Uzuner Nevzat,Şenol Mehmet Güney,YILMAZ ARDA,Gökçe Mustafa,DEMİRCİ Seden,Yilmaz Kusbeci Ozge,TEKGÖL UZUNER GÜLNUR,Batur Caglayan Hale,AÇIKGÖZ Mustafa,KURUCU HATICE,OZDAG Mehmet Fatih,Baybas Sevim,Ekmekci Hakan,Cabalar Murat,Yaman Mehmet,Bektaş Hesna,kaplan yuksel,GÖKSEL Karakurum Başak,MİLANLIOĞLU Aysel,Necioglu Orken Dilek,ALUCLU Mehmet Ufuk,ÇOLAKOĞLU Sena,TÜFEKÇİ AHMET,Bakar Mustafa,Nazliel Bijen,Tascilar Nida,Goksan Baki,Kozak Hasan Hüseyin,mısırlı cemile handan,Küçükoğlu Hayriye,Midi Ipek,MENGÜLLÜOĞLU Necdet,aytac emrah,Yesilot Nilufer,İNCE Birsen,Yalın Osman Özgür,GÜNEŞ TAŞKIN,ORUÇ Serdar,Demir Serkan Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. , 2021, ss.7 - 14. 10.14744/agri.2020.77698
AMA	DUMAN T,Cinar N,UGURLU D,domac f,Ozturk S,Yayla V,karahan a,Afsar N,SUNGUR M,ozaydin goksu e,Yurekli V,Genç H,UTKU U,Sahin S,TEKELI H,TOKUÇ F,Uzuner N,Şenol M,YILMAZ A,Gökçe M,DEMİRCİ S,Yilmaz Kusbeci O,TEKGÖL UZUNER G,Batur Caglayan H,AÇIKGÖZ M,KURUCU H,OZDAG M,Baybas S,Ekmekci H,Cabalar M,Yaman M,Bektaş H,kaplan y,GÖKSEL K,MİLANLIOĞLU A,Necioglu Orken D,ALUCLU M,ÇOLAKOĞLU S,TÜFEKÇİ A,Bakar M,Nazliel B,Tascilar N,Goksan B,Kozak H,mısırlı c,Küçükoğlu H,Midi I,MENGÜLLÜOĞLU N,aytac e,Yesilot N,İNCE B,Yalın O,GÜNEŞ T,ORUÇ S,Demir S Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. . 2021; 7 - 14. 10.14744/agri.2020.77698
Vancouver	DUMAN T,Cinar N,UGURLU D,domac f,Ozturk S,Yayla V,karahan a,Afsar N,SUNGUR M,ozaydin goksu e,Yurekli V,Genç H,UTKU U,Sahin S,TEKELI H,TOKUÇ F,Uzuner N,Şenol M,YILMAZ A,Gökçe M,DEMİRCİ S,Yilmaz Kusbeci O,TEKGÖL UZUNER G,Batur Caglayan H,AÇIKGÖZ M,KURUCU H,OZDAG M,Baybas S,Ekmekci H,Cabalar M,Yaman M,Bektaş H,kaplan y,GÖKSEL K,MİLANLIOĞLU A,Necioglu Orken D,ALUCLU M,ÇOLAKOĞLU S,TÜFEKÇİ A,Bakar M,Nazliel B,Tascilar N,Goksan B,Kozak H,mısırlı c,Küçükoğlu H,Midi I,MENGÜLLÜOĞLU N,aytac e,Yesilot N,İNCE B,Yalın O,GÜNEŞ T,ORUÇ S,Demir S Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. . 2021; 7 - 14. 10.14744/agri.2020.77698
IEEE	DUMAN T,Cinar N,UGURLU D,domac f,Ozturk S,Yayla V,karahan a,Afsar N,SUNGUR M,ozaydin goksu e,Yurekli V,Genç H,UTKU U,Sahin S,TEKELI H,TOKUÇ F,Uzuner N,Şenol M,YILMAZ A,Gökçe M,DEMİRCİ S,Yilmaz Kusbeci O,TEKGÖL UZUNER G,Batur Caglayan H,AÇIKGÖZ M,KURUCU H,OZDAG M,Baybas S,Ekmekci H,Cabalar M,Yaman M,Bektaş H,kaplan y,GÖKSEL K,MİLANLIOĞLU A,Necioglu Orken D,ALUCLU M,ÇOLAKOĞLU S,TÜFEKÇİ A,Bakar M,Nazliel B,Tascilar N,Goksan B,Kozak H,mısırlı c,Küçükoğlu H,Midi I,MENGÜLLÜOĞLU N,aytac e,Yesilot N,İNCE B,Yalın O,GÜNEŞ T,ORUÇ S,Demir S "Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study." , ss.7 - 14, 2021. 10.14744/agri.2020.77698
ISNAD	DUMAN, Taşkın vd. "Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study". (2021), 7-14. https://doi.org/10.14744/agri.2020.77698

APA	DUMAN T, Cinar N, UGURLU D, domac f, Ozturk S, Yayla V, karahan a, Afsar N, SUNGUR M, ozaydin goksu e, Yurekli V, Genç H, UTKU U, Sahin S, TEKELI H, TOKUÇ F, Uzuner N, Şenol M, YILMAZ A, Gökçe M, DEMİRCİ S, Yilmaz Kusbeci O, TEKGÖL UZUNER G, Batur Caglayan H, AÇIKGÖZ M, KURUCU H, OZDAG M, Baybas S, Ekmekci H, Cabalar M, Yaman M, Bektaş H, kaplan y, GÖKSEL K, MİLANLIOĞLU A, Necioglu Orken D, ALUCLU M, ÇOLAKOĞLU S, TÜFEKÇİ A, Bakar M, Nazliel B, Tascilar N, Goksan B, Kozak H, mısırlı c, Küçükoğlu H, Midi I, MENGÜLLÜOĞLU N, aytac e, Yesilot N, İNCE B, Yalın O, GÜNEŞ T, ORUÇ S, Demir S (2021). Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. Ağrı, 33(1), 7 - 14. 10.14744/agri.2020.77698
Chicago	DUMAN Taşkın,Cinar Nilgun,UGURLU DERYA,domac fusun,Ozturk Serefnur,Yayla Vildan,karahan ali yavuz,Afsar Nazire,SUNGUR Mehmet Ali,ozaydin goksu eylem,Yurekli Vedat Ali,Genç Hamit,UTKU UYGAR,Sahin Sevki,TEKELI Hakan,TOKUÇ Firdevs Ezgi,Uzuner Nevzat,Şenol Mehmet Güney,YILMAZ ARDA,Gökçe Mustafa,DEMİRCİ Seden,Yilmaz Kusbeci Ozge,TEKGÖL UZUNER GÜLNUR,Batur Caglayan Hale,AÇIKGÖZ Mustafa,KURUCU HATICE,OZDAG Mehmet Fatih,Baybas Sevim,Ekmekci Hakan,Cabalar Murat,Yaman Mehmet,Bektaş Hesna,kaplan yuksel,GÖKSEL Karakurum Başak,MİLANLIOĞLU Aysel,Necioglu Orken Dilek,ALUCLU Mehmet Ufuk,ÇOLAKOĞLU Sena,TÜFEKÇİ AHMET,Bakar Mustafa,Nazliel Bijen,Tascilar Nida,Goksan Baki,Kozak Hasan Hüseyin,mısırlı cemile handan,Küçükoğlu Hayriye,Midi Ipek,MENGÜLLÜOĞLU Necdet,aytac emrah,Yesilot Nilufer,İNCE Birsen,Yalın Osman Özgür,GÜNEŞ TAŞKIN,ORUÇ Serdar,Demir Serkan Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. Ağrı 33, no.1 (2021): 7 - 14. 10.14744/agri.2020.77698
MLA	DUMAN Taşkın,Cinar Nilgun,UGURLU DERYA,domac fusun,Ozturk Serefnur,Yayla Vildan,karahan ali yavuz,Afsar Nazire,SUNGUR Mehmet Ali,ozaydin goksu eylem,Yurekli Vedat Ali,Genç Hamit,UTKU UYGAR,Sahin Sevki,TEKELI Hakan,TOKUÇ Firdevs Ezgi,Uzuner Nevzat,Şenol Mehmet Güney,YILMAZ ARDA,Gökçe Mustafa,DEMİRCİ Seden,Yilmaz Kusbeci Ozge,TEKGÖL UZUNER GÜLNUR,Batur Caglayan Hale,AÇIKGÖZ Mustafa,KURUCU HATICE,OZDAG Mehmet Fatih,Baybas Sevim,Ekmekci Hakan,Cabalar Murat,Yaman Mehmet,Bektaş Hesna,kaplan yuksel,GÖKSEL Karakurum Başak,MİLANLIOĞLU Aysel,Necioglu Orken Dilek,ALUCLU Mehmet Ufuk,ÇOLAKOĞLU Sena,TÜFEKÇİ AHMET,Bakar Mustafa,Nazliel Bijen,Tascilar Nida,Goksan Baki,Kozak Hasan Hüseyin,mısırlı cemile handan,Küçükoğlu Hayriye,Midi Ipek,MENGÜLLÜOĞLU Necdet,aytac emrah,Yesilot Nilufer,İNCE Birsen,Yalın Osman Özgür,GÜNEŞ TAŞKIN,ORUÇ Serdar,Demir Serkan Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. Ağrı, vol.33, no.1, 2021, ss.7 - 14. 10.14744/agri.2020.77698
AMA	DUMAN T,Cinar N,UGURLU D,domac f,Ozturk S,Yayla V,karahan a,Afsar N,SUNGUR M,ozaydin goksu e,Yurekli V,Genç H,UTKU U,Sahin S,TEKELI H,TOKUÇ F,Uzuner N,Şenol M,YILMAZ A,Gökçe M,DEMİRCİ S,Yilmaz Kusbeci O,TEKGÖL UZUNER G,Batur Caglayan H,AÇIKGÖZ M,KURUCU H,OZDAG M,Baybas S,Ekmekci H,Cabalar M,Yaman M,Bektaş H,kaplan y,GÖKSEL K,MİLANLIOĞLU A,Necioglu Orken D,ALUCLU M,ÇOLAKOĞLU S,TÜFEKÇİ A,Bakar M,Nazliel B,Tascilar N,Goksan B,Kozak H,mısırlı c,Küçükoğlu H,Midi I,MENGÜLLÜOĞLU N,aytac e,Yesilot N,İNCE B,Yalın O,GÜNEŞ T,ORUÇ S,Demir S Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. Ağrı. 2021; 33(1): 7 - 14. 10.14744/agri.2020.77698
Vancouver	DUMAN T,Cinar N,UGURLU D,domac f,Ozturk S,Yayla V,karahan a,Afsar N,SUNGUR M,ozaydin goksu e,Yurekli V,Genç H,UTKU U,Sahin S,TEKELI H,TOKUÇ F,Uzuner N,Şenol M,YILMAZ A,Gökçe M,DEMİRCİ S,Yilmaz Kusbeci O,TEKGÖL UZUNER G,Batur Caglayan H,AÇIKGÖZ M,KURUCU H,OZDAG M,Baybas S,Ekmekci H,Cabalar M,Yaman M,Bektaş H,kaplan y,GÖKSEL K,MİLANLIOĞLU A,Necioglu Orken D,ALUCLU M,ÇOLAKOĞLU S,TÜFEKÇİ A,Bakar M,Nazliel B,Tascilar N,Goksan B,Kozak H,mısırlı c,Küçükoğlu H,Midi I,MENGÜLLÜOĞLU N,aytac e,Yesilot N,İNCE B,Yalın O,GÜNEŞ T,ORUÇ S,Demir S Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study. Ağrı. 2021; 33(1): 7 - 14. 10.14744/agri.2020.77698
IEEE	DUMAN T,Cinar N,UGURLU D,domac f,Ozturk S,Yayla V,karahan a,Afsar N,SUNGUR M,ozaydin goksu e,Yurekli V,Genç H,UTKU U,Sahin S,TEKELI H,TOKUÇ F,Uzuner N,Şenol M,YILMAZ A,Gökçe M,DEMİRCİ S,Yilmaz Kusbeci O,TEKGÖL UZUNER G,Batur Caglayan H,AÇIKGÖZ M,KURUCU H,OZDAG M,Baybas S,Ekmekci H,Cabalar M,Yaman M,Bektaş H,kaplan y,GÖKSEL K,MİLANLIOĞLU A,Necioglu Orken D,ALUCLU M,ÇOLAKOĞLU S,TÜFEKÇİ A,Bakar M,Nazliel B,Tascilar N,Goksan B,Kozak H,mısırlı c,Küçükoğlu H,Midi I,MENGÜLLÜOĞLU N,aytac e,Yesilot N,İNCE B,Yalın O,GÜNEŞ T,ORUÇ S,Demir S "Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study." Ağrı, 33, ss.7 - 14, 2021. 10.14744/agri.2020.77698
ISNAD	DUMAN, Taşkın vd. "Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study". Ağrı 33/1 (2021), 7-14. https://doi.org/10.14744/agri.2020.77698