Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats

özer, mustafa; Kekeç, Ahmet Fevzi; oltulu, pembe; KORUCU, İsmail Hakkı; ARSLAN, ABDULLAH

doi:10.5606/ehc.2020.72592

Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats

İsmail Hakkı KORUCU, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Konya, Türkiye)

Ahmet Fevzi KEKEÇ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Konya, Türkiye)

Abdullah ARSLAN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Sualtı ve Hiperbarik Tıp Anabilim Dalı, Konya, Türkiye)

Pembe Oltulu, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Patoloji Anabilim Dalı, Konya, Türkiye)

Mustafa ÖZER (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Konya, Türkiye)

Joint diseases and related surgery

3 0

Yıl: 2020 Cilt: 31 Sayı: 2 Sayfa Aralığı: 260 - 266 Metin Dili: İngilizce DOI: 10.5606/ehc.2020.72592 İndeks Tarihi: 04-05-2021

Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats

Öz:

Objectives: This study aims to investigate the effects of hyperbaric oxygen (HBO) therapy and platelet-rich plasma (PRP) on the regeneration of osteochondral defects of the rats, and the synergistic effect of this combined treatment.Materialsandmethods:This randomized, controlled, and interventional animal study was conducted between May 2014 and August 2014 Osteochondral regeneration was evaluated in four treatment groups (control, PRP, HBO, and HBO+PRP groups) at the 30th day after iatrogenic injury. Thirty-two female Wistar albino rats (weighing 248-305 g) underwent arthrotomy and osteochondral surgery on left knees. The regenerations of defects were then examined histologically by the modified version of O’Driscoll score.Results: Groups that were treated with either HBO or PRP alone regenerated significantly better than the control group (p=0.01), while no significant difference was found between the HBO- and PRP-treated groups (p>0.05). The defects in group 4 (treated with both HBO and PRP) regenerated significantly better than the control group, the HBO-treated group alone, and the PRP-treated group alone (p=0.01).Conclusion: The results of this study showed a synergistic effect of HBO and PRP on knee cartilage regeneration. However, the possible underlying mechanisms should be the subject of future researches. The aggregation and activation of growth factors released from platelets whose activation is increased in the hyperbaric environment may explain this effect. This may result in a better regeneration than the effect of PRP or HBO alone.

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APA	KORUCU İ, Kekeç A, ARSLAN A, oltulu p, özer m (2020). Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. , 260 - 266. 10.5606/ehc.2020.72592
Chicago	KORUCU İsmail Hakkı,Kekeç Ahmet Fevzi,ARSLAN ABDULLAH,oltulu pembe,özer mustafa Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. (2020): 260 - 266. 10.5606/ehc.2020.72592
MLA	KORUCU İsmail Hakkı,Kekeç Ahmet Fevzi,ARSLAN ABDULLAH,oltulu pembe,özer mustafa Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. , 2020, ss.260 - 266. 10.5606/ehc.2020.72592
AMA	KORUCU İ,Kekeç A,ARSLAN A,oltulu p,özer m Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. . 2020; 260 - 266. 10.5606/ehc.2020.72592
Vancouver	KORUCU İ,Kekeç A,ARSLAN A,oltulu p,özer m Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. . 2020; 260 - 266. 10.5606/ehc.2020.72592
IEEE	KORUCU İ,Kekeç A,ARSLAN A,oltulu p,özer m "Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats." , ss.260 - 266, 2020. 10.5606/ehc.2020.72592
ISNAD	KORUCU, İsmail Hakkı vd. "Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats". (2020), 260-266. https://doi.org/10.5606/ehc.2020.72592

APA	KORUCU İ, Kekeç A, ARSLAN A, oltulu p, özer m (2020). Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. Joint diseases and related surgery, 31(2), 260 - 266. 10.5606/ehc.2020.72592
Chicago	KORUCU İsmail Hakkı,Kekeç Ahmet Fevzi,ARSLAN ABDULLAH,oltulu pembe,özer mustafa Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. Joint diseases and related surgery 31, no.2 (2020): 260 - 266. 10.5606/ehc.2020.72592
MLA	KORUCU İsmail Hakkı,Kekeç Ahmet Fevzi,ARSLAN ABDULLAH,oltulu pembe,özer mustafa Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. Joint diseases and related surgery, vol.31, no.2, 2020, ss.260 - 266. 10.5606/ehc.2020.72592
AMA	KORUCU İ,Kekeç A,ARSLAN A,oltulu p,özer m Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. Joint diseases and related surgery. 2020; 31(2): 260 - 266. 10.5606/ehc.2020.72592
Vancouver	KORUCU İ,Kekeç A,ARSLAN A,oltulu p,özer m Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats. Joint diseases and related surgery. 2020; 31(2): 260 - 266. 10.5606/ehc.2020.72592
IEEE	KORUCU İ,Kekeç A,ARSLAN A,oltulu p,özer m "Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats." Joint diseases and related surgery, 31, ss.260 - 266, 2020. 10.5606/ehc.2020.72592
ISNAD	KORUCU, İsmail Hakkı vd. "Regenerative effects of hyperbaric oxygen therapy and platelet-rich plasma on the osteochondral defects of rats". Joint diseases and related surgery 31/2 (2020), 260-266. https://doi.org/10.5606/ehc.2020.72592