TY  - JOUR
TI  - The Effects of S-Allyl Cysteıne on Inflammatory Cascade in Lipopolysaccharide Induced Rat Sepsis Model
AB  - Lipopolysaccharide (LPS) is a main constituent of Gram-negative bacterial cell walls and is considered a leading cause of sepsis.S-allyl cysteine (SAC) is a water-soluble organosulfur component present in garlic which has a potent antioxidant and free radicalscavenger activity. The purpose of this study is to examine the antioxidant and anti-inflammatory potential of SAC on endotoxinLPS-induced sepsis. Female Wistar albino rats were divided into 6 groups. LPS (5 mg/kg) was applied to rats in sepsis and treatment groups intraperitoneally. After 24 hours from LPS injection 50 mg/kg and 100 mg/kg SAC was orally administrated totreatment groups. Lung and liver 18F-fluoro-deoxy-D-glucose (18F-FDG) uptake was measured by 18FDG-PET scan. Serumlevels of nuclear factor-kappa B (NF-κβ), tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-9 (MMP-9), plasmalevels of interleukin-1β (IL-1β), IL-6 and tissue levels of oxidative stress markers catalase (CAT), superoxide dismutase (SOD),malondialdehyde (MDA) and nitric oxide (NO) were determined. As a result of the study, MDA and NO levels of sepsis groupwere significantly higher than treatment groups in lung tissue. SOD activities of sepsis group was determined to significantly lowerin the liver and lung tissues than the groups which were treated with SAC. Likewise, it was concluded that serum MMP-9, TNF-αand NF-κβ levels of sepsis group was significantly higher compared to levels of treatment groups. It was determined that SACadministration reduced 18F-FDG uptake in septic rats. In conclusion, SAC was observed to diminish effects of the acute toxicityand oxidative stress formed with LPS.
AU  - KOLAÇ, Umut Kerem
AU  - Entok, Emre
AU  - ÜSTÜNER, MEHMET CENGIZ
AU  - Tekin Karacaer, Neslihan
AU  - AKYÜZ, FAHRETTIN
AU  - Alataş, İ. Özkan
AU  - tanrikut, cihan
DO  - 10.20515/otd.749410
PY  - 2021
JO  - Osmangazi Tıp Dergisi
VL  - 43
IS  - 2
SN  - 1305-4953
SP  - 94
EP  - 105
DB  - TRDizin
UR  - http://search/yayin/detay/409205
ER  -