Yıl: 2021 Cilt: 22 Sayı: 1 Sayfa Aralığı: 47 - 52 Metin Dili: İngilizce DOI: 10.4274/jtgga.galenos.2021.2020.0127 İndeks Tarihi: 06-05-2021

Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study

Öz:
Objective: This study evaluated the effect of endometrial injury on pregnancy outcomes in patients with a poor ovarian response (POR), based on the Bologna criteria, who underwent intracytoplasmic sperm injection (ICSI) cycles.Material and Methods: Sixty-eight patients were enrolled in this retrospective cohort study. All patients in the endometrial scratching group (group 1, n=32) and control group (group 2, n=36) underwent office hysteroscopy in the early follicular phase of the cycle before controlled ovarian stimulation. Group 1 also underwent endometrial scratching. The main outcome measure was the ongoing pregnancy rate.Results: The study groups had similar baseline demographics, including age, body mass index, duration of infertility, number of ICSI cycles, and hormone levels. However, the antral follicle count was significantly higher in group 1 than in group 2 (4.2±1.9 vs 3.3±1.8; p<0.05). There were no significant group differences in ovarian stimulation characteristics (ovarian stimulation time, trigger day endometrial thickness, number of metaphase II oocytes), number of embryos transferred, or the ratio of embryo transfer on days 3 and 5. Moreover, there were no significant differences between groups 1 and 2 in the rates of chemical pregnancy (25% vs 19.4%), clinical pregnancy (15.6% vs 11.1%) or ongoing pregnancy (9.4% vs 8.3%) (p>0.05 for all).Conclusion: Endometrial scratching did not improve pregnancy outcomes for patients meeting the Bologna criteria for a POR to ICSI cycles using fresh embryo transfer and the GnRH antagonist protocol. (J Turk Ger Gynecol Assoc 2021; 22: 47-52)
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. European Society of Human Reproduction and Embryology. More than 8 million babies born from IVF since the world’s first in 1978: European IVF pregnancy rates now steady at around 36 percent, according to ESHRE monitoring. ScienceDaily, 2018.
  • 2. Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod 2011; 26: 1768-74.
  • 3. Patrizio P, Vaiarelli A, Levi Setti PE, Tobler KJ, Shoham G, Leong M, et al. How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics. Reprod Biomed Online 2015; 30: 581-92.
  • 4. Oudendijk JF, Yarde F, Eijkemans MJ, Broekmans FJ, Broer SL. The poor responder in IVF: is the prognosis always poor?: a systematic review. Hum Reprod Update 2012; 18: 1-11.
  • 5. Ubaldi F, Vaiarelli A, D’Anna R, Rienzi L. Management of poor responders in IVF: is there anything new? Biomed Res Int 2014; 2014: 352098.
  • 6. Simón C, Moreno C, Remohí J, Pellicer A. Molecular interactions between embryo and uterus in the adhesion phase of human implantation. Hum Reprod 1998; 13(Suppl 3): 219-32 discussion 233-16.
  • 7. Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 2006; 21: 3036-43.
  • 8. Zhang Y, Zhang C, Shu J, Guo J, Chang HM, Leung PCK. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update 2020; 26: 247-63.
  • 9. Lensen S, Sadler L, Farquhar C. Endometrial scratching for subfertility: everyone's doing it. Hum Reprod 2016; 31: 1241-4.
  • 10. Ko JK, Ng EH. Scratching and IVF: any role? Curr Opin Obstet Gynecol 2016; 28: 178-83.
  • 11. Vitagliano A, Di Spiezio Sardo A, Saccone G, Valenti G, Sapia F, Kamath MS, et al. Endometrial scratch injury for women with one or more previous failed embryo transfers: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2018; 110: 687-702.e2.
  • 12. Vitagliano A, Andrisani A, Alviggi C, Vitale SG, Valenti G, Sapia F, et al. Endometrial scratching for infertile women undergoing a first embryo transfer: a systematic review and meta-analysis of published and unpublished data from randomized controlled trials. Fertil Steril 2019; 111: 734-746.e2.
  • 13. Farquhar C. Endometrial scratching: how much evidence do you need to stop offering this to women having in vitro fertilization? Fertil Steril 2019; 111: 1092-3.
  • 14. Lensen S, Venetis C, Ng EHY, Young SL, Vitagliano A, Macklon NS, et al. Should we stop offering endometrial scratching prior to in vitro fertilization? Fertil Steril 2019; 111: 1094-101.
  • 15. van Hoogenhuijze NE, Kasius JC, Broekmans FJM, Bosteels J, Torrance HL. Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis. Hum Reprod Open 2019; 2019: hoy025.
  • 16. Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L; ESHRE working group on Poor Ovarian Response Definition. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 2011; 26: 1616-24.
  • 17. Polyzos NP, Devroey P. A systematic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? Fertil Steril 2011; 96: 1058-61.e7.
  • 18. Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94: 2030-6.
  • 19. Granot I, Dekel N, Bechor E, Segal I, Fieldust S, Barash A. Temporal analysis of connexin43 protein and gene expression throughout the menstrual cycle in human endometrium. Fertil Steril 2000; 73: 381-6.
  • 20. Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril 2003; 79: 1317-22.
  • 21. Tumanyan A, Gemilyan M, Hambartsoumian E. Single and double endometrial scratching (ES) in infertile women with strict criteria of recurrent implantation failure (RIF). Gynecol Endocrinol 2019; 35(Suppl): 11-4.
  • 22. Maged AM, Rashwan H, AbdelAziz S, Ramadan W, Mostafa WAI, Metwally AA, et al. Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle. Int J Gynecol Obstet 2018; 140: 211-6.
  • 23. Bar G, Harlev A, Alfayumi-Zeadna S, Zeadna A, Bord I, Har-Vardi I, et al. Recurrent implantation failure: which patients benefit from endometrial scratching prior to IVF? Arch Gynecol Obstet 2020; 301: 817-22.
  • 24. Eskew AM, Reschke LD, Woolfolk C, Schulte MB, Boots CE, Broughton DE, et al. Effect of endometrial mechanical stimulation in an unselected population undergoing in vitro fertilization: futility analysis of a double-blind randomized controlled trial. J Assist Reprod Genet 2019; 36: 299-305.
  • 25. Frantz S, Parinaud J, Kret M, Rocher-Escriva G, Papaxanthos-Roche A, Creuxz H, et al. Decrease in pregnancy rate after endometrial scratch in women undergoing a first or second in vitro fertilization. A multicenter randomized controlled trial. Hum Reprod 2019; 34: 92-9.
  • 26. Lensen S, Osavlyuk D, Armstrong S, Stadelmann C, Hennes A, Napier E, et al. A Randomized Trial of Endometrial Scratching before In Vitro Fertilization. N Engl J Med 2019; 380: 325-3
  • 27. Pluddemann A, Onakpoya I. Endometrial scratching before in vitro fertilisation does not increase live birth rate. BMJ Evid Based Med 2020; 25: 38-9.
  • 28. Kumbak B, Sahin L, Ozkan S, Atilgan R. Impact of luteal phase hysteroscopy and concurrent endometrial biopsy on subsequent IVF cycle outcome. Arch Gynecol Obstet 2014; 290: 369-74.
  • 29. Seval MM, Şükür YE, Özmen B, Kan Ö, Sönmezer M, Berker B, et al. Does adding endometrial scratching to diagnostic hysteroscopy improve pregnancy rates in women with recurrent in-vitro fertilization failure? Gynecol Endocrinol 2016; 32: 957-60.
  • 30. Günther V, von Otte S, Maass N, Alkatout I. Endometrial “Scratching” An update and overview of current research. J Turk Ger Gynecol Assoc 2020; 21: 124-9.
  • 31. Shohayeb A, El-Khayat W. Does a single endometrial biopsy regimen (S-EBR) improve ICSI outcome in patients with repeated implantation failure? A randomised controlled trial. Eur J Obstet Gynecol Reprod Biol 2012; 164: 176-9.
  • 32. Liu W, Tal R, Chao H, Liu M, Liu Y. Effect of local endometrial injury in proliferative vs. luteal phase on IVF outcomes in unselected subfertile women undergoing in vitro fertilization. Reprod Biol Endocrinol 2017; 15: 75
APA Kalyoncu Ş, Yazıcıoğlu A, demir m (2021). Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. , 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
Chicago Kalyoncu Şenol,Yazıcıoğlu Aslıhan,demir mustafa Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. (2021): 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
MLA Kalyoncu Şenol,Yazıcıoğlu Aslıhan,demir mustafa Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. , 2021, ss.47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
AMA Kalyoncu Ş,Yazıcıoğlu A,demir m Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. . 2021; 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
Vancouver Kalyoncu Ş,Yazıcıoğlu A,demir m Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. . 2021; 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
IEEE Kalyoncu Ş,Yazıcıoğlu A,demir m "Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study." , ss.47 - 52, 2021. 10.4274/jtgga.galenos.2021.2020.0127
ISNAD Kalyoncu, Şenol vd. "Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study". (2021), 47-52. https://doi.org/10.4274/jtgga.galenos.2021.2020.0127
APA Kalyoncu Ş, Yazıcıoğlu A, demir m (2021). Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. Journal of the Turkish-German Gynecological Association, 22(1), 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
Chicago Kalyoncu Şenol,Yazıcıoğlu Aslıhan,demir mustafa Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. Journal of the Turkish-German Gynecological Association 22, no.1 (2021): 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
MLA Kalyoncu Şenol,Yazıcıoğlu Aslıhan,demir mustafa Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. Journal of the Turkish-German Gynecological Association, vol.22, no.1, 2021, ss.47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
AMA Kalyoncu Ş,Yazıcıoğlu A,demir m Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. Journal of the Turkish-German Gynecological Association. 2021; 22(1): 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
Vancouver Kalyoncu Ş,Yazıcıoğlu A,demir m Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study. Journal of the Turkish-German Gynecological Association. 2021; 22(1): 47 - 52. 10.4274/jtgga.galenos.2021.2020.0127
IEEE Kalyoncu Ş,Yazıcıoğlu A,demir m "Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study." Journal of the Turkish-German Gynecological Association, 22, ss.47 - 52, 2021. 10.4274/jtgga.galenos.2021.2020.0127
ISNAD Kalyoncu, Şenol vd. "Endometrial scratching for poor responders basedon the Bologna criteria in ICSI fresh embryo transfercycles: a preliminary retrospective cohort study". Journal of the Turkish-German Gynecological Association 22/1 (2021), 47-52. https://doi.org/10.4274/jtgga.galenos.2021.2020.0127