L-Karnitin Depresyon Üzerinde Etkili Midir?

tekin, tuba; Ayaz, Aylin

doi:10.22312/sdusbed.602903

L-Karnitin Depresyon Üzerinde Etkili Midir?

Tuba TEKİN, (Sivas Cumhuriyet Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü)

Aylin AYAZ (Hacettepe Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü)

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi

31 1

Yıl: 2020 Cilt: 11 Sayı: 1 Sayfa Aralığı: 100 - 106 Metin Dili: Türkçe DOI: 10.22312/sdusbed.602903 İndeks Tarihi: 07-05-2021

L-Karnitin Depresyon Üzerinde Etkili Midir?

Öz:

Karnitin hem endojen biyosentez yoluyla vücuttasentezlenmekte hem de günlük diyetle besinlerdenalınmaktadır. Karnitin (trimetilamino-β-hidroksibutirat),hücre ve dokularda, açil-L-karnitin dahil olmak üzere hemserbest karnitin hem de açilkarnitinler olarak bulunmaktadır.Karnitin uzun zincirli yağ asitlerinin β-oksidasyonu içinmitokondriye taşıyıcı olarak görev yapmaktadır. Karnitinkarboksilik asitler ile ester oluşturma yeteneğinden dolayıdiğer metabolitlerin taşınmasında da önem taşımaktadır.Ayrıca karnitin nörotransmitterlerin aktivitesini modüle edereksinir sisteminde önemli rol oynamaktadır. Depresyon yaşamkalitesinin büyük ölçüde azalması, eşlik eden hastalıklarınartması ve artmış ölüm oranı ile ilişkili bir bozukluktur.Depresyonlu bireylerde yağ asitleri ve lipit metabolizmasıdeğişikliklerinin oluştuğu bildirilmiştir. Bu nedenle karnitinin,sinir dokularındaki çeşitli nörotrofik faktörlerin, hücrezarlarının, lipid metabolizmasının ve nörotransmitterlerinaktivitesini modüle ettiği düşünüldüğünde, depresyontedavisinde karnitin takviyesinin antidepresanlara alternatiftedavi edici ajan olarak potansiyel bir rolü olduğu ilerisürülmüştür. Karnitin beyinde yaygın olarak bulunmakta vekolinerjik reseptörler üzerinde uyarıcı etki göstermektedir.Ayrıca karnitin nöromodülatör etki göstererek dopaminsalınımının artmasını ve gama-aminobutirik asidin artmasınısağlamaktadır. Karnitin sinir sisteminde antioksidan venörotrofik etki göstermektedir. Hayvan ve insan modelli klinikçalışmalarda depresyon üzerinde karnitinin olumlu etkilerininolduğu belirlenmiştir. L-karnitinin antidepresan ilaçlar ilebenzer etki gösterdiği ve yan etkilerinin daha düşük olduğuçalışmalarla gösterilmiştir. Karnitin takviyesinin antidepresanve nörotrofik etkilerinden dolayı depresyon tedavisinde etkinrolü olabileceği düşünülmektedir.

Anahtar Kelime:

Is L-Carnitine Effective on Depression?

Öz:

Carnitine is synthesized both by endogenous biosynthesis in the body and is taken from foods with daily diet. Carnitine (trimethyl amino-β-hydroxybutyrate) is present in cells and tissues as both free carnitine and acylcarnitins, including acetyl-L-carnitine. Carnitine acts as a carrier of mitochondria for the β-oxidation of long chain fatty acids. Carnitine is also important in the transport of other metabolites due to its ability to form esters with carboxylic acids. Carnitine also plays a role in the nervous system by modulating the activity of neurotransmitters. Depression is a disorder associated with a significant decrease in quality of life, increased physical comorbidities, and increased mortality. It is thought that changes in fatty acids and lipid metabolism occur in individuals with depression. Therefore, when carnitine is thought to modulate the activity of various neurotrophic factors, cell membranes, lipid metabolism and neurotransmitters in nerve tissues, carnitine supplementation has been suggested to have a potential role as an alternative therapeutic agent to antidepressants. Carnitine is common in the brain and has a stimulating effect on cholinergic receptors. In addition, carnitine exhibits neuromodulatory effect and increases dopamine release and increases gamma-aminobutyric acid. Carnitine has antioxidant and neurotrophic effects in nervous system. Animal and human model clinical studies have shown positive effects of carnitine on depression. Studies have shown that L-carnitine has similar effects with antidepressant drugs and has lower side effects. It is thought that carnitine supplementation may have an effective role in the treatment of depression due to its antidepressant and neurotrophic effects.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	tekin t, Ayaz A (2020). L-Karnitin Depresyon Üzerinde Etkili Midir?. , 100 - 106. 10.22312/sdusbed.602903
Chicago	tekin tuba,Ayaz Aylin L-Karnitin Depresyon Üzerinde Etkili Midir?. (2020): 100 - 106. 10.22312/sdusbed.602903
MLA	tekin tuba,Ayaz Aylin L-Karnitin Depresyon Üzerinde Etkili Midir?. , 2020, ss.100 - 106. 10.22312/sdusbed.602903
AMA	tekin t,Ayaz A L-Karnitin Depresyon Üzerinde Etkili Midir?. . 2020; 100 - 106. 10.22312/sdusbed.602903
Vancouver	tekin t,Ayaz A L-Karnitin Depresyon Üzerinde Etkili Midir?. . 2020; 100 - 106. 10.22312/sdusbed.602903
IEEE	tekin t,Ayaz A "L-Karnitin Depresyon Üzerinde Etkili Midir?." , ss.100 - 106, 2020. 10.22312/sdusbed.602903
ISNAD	tekin, tuba - Ayaz, Aylin. "L-Karnitin Depresyon Üzerinde Etkili Midir?". (2020), 100-106. https://doi.org/10.22312/sdusbed.602903

APA	tekin t, Ayaz A (2020). L-Karnitin Depresyon Üzerinde Etkili Midir?. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, 11(1), 100 - 106. 10.22312/sdusbed.602903
Chicago	tekin tuba,Ayaz Aylin L-Karnitin Depresyon Üzerinde Etkili Midir?. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 11, no.1 (2020): 100 - 106. 10.22312/sdusbed.602903
MLA	tekin tuba,Ayaz Aylin L-Karnitin Depresyon Üzerinde Etkili Midir?. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, vol.11, no.1, 2020, ss.100 - 106. 10.22312/sdusbed.602903
AMA	tekin t,Ayaz A L-Karnitin Depresyon Üzerinde Etkili Midir?. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2020; 11(1): 100 - 106. 10.22312/sdusbed.602903
Vancouver	tekin t,Ayaz A L-Karnitin Depresyon Üzerinde Etkili Midir?. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2020; 11(1): 100 - 106. 10.22312/sdusbed.602903
IEEE	tekin t,Ayaz A "L-Karnitin Depresyon Üzerinde Etkili Midir?." Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, 11, ss.100 - 106, 2020. 10.22312/sdusbed.602903
ISNAD	tekin, tuba - Ayaz, Aylin. "L-Karnitin Depresyon Üzerinde Etkili Midir?". Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 11/1 (2020), 100-106. https://doi.org/10.22312/sdusbed.602903