The first case of coronavirus disease 2019 (COVID-19) was defined as unexplained pneumonia on December 8, 2019, and then it rapidly caused apandemic and affected transplantation rates negatively. Organ donation processes got more complex because the exclusion of the disease in a shortperiod became more difficult than normal. The exclusion of the disease is vital not only for recipients but also for the medical staff, transplantationteams, and intensive care professionals to reduce the transmission risk. The main steps for diagnosis of COVID-19 are investigation of symptoms,recollection of travel and physical contact history, and testing using the real time polymerase chain reaction (RT-PCR) test. Although it has limitations such as false negative results, RT-PCR is the most accurate method to detect COVID-19, and it is mandatory before donation processesin many countries. In this case report, we aim to share our experience about the first organ donation during the COVID-19 pandemic in Turkey.