Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels

YAKINCI, Cengiz; RAFİQ, Mehmet; DURMAZ, Rıza; KÖROĞLU, MEHMET; Yologlu, Saim; DURMAZ, Bengül

Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels

Bengül DURMAZ, (İnönü Üniversitesi, Tıp Fakültesi, Klinik Mikrobiyoloji Anabilim Dalı, Malatya, Türkiye)

Cengiz YAKINCI, (Girilmedi)

Mehmet KÖROĞLU, (Girilmedi)

Mehmet RAFİQ, (Girilmedi)

Rıza DURMAZ, (Girilmedi)

Saim YOLOĞLU (Girilmedi)

İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi

4 0

Yıl: 1996 Cilt: 3 Sayı: 4 Sayfa Aralığı: 332 - 335 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels

Öz:

Yaşları 7-11 arasında değişen, parazit ile enfekte 90 çocuk ve 24 sağlıklı çocukta serum IgE konsantrasyonları enzim immunoassay yöntemi ile' ölçüldü. Parazit bulunan 90 çocuğun 46'sı Giardia lamblia, 26'sı Enterobius vermicularis ve 18'i de her iki parazit ile enfekte idi. Parazit ile enfekte çocuklarda ortalama IgE değeri 170.17±27.76 IU/ml idi; bu çocukların 24'ünde IgE değeri 100 lU/ml'nin, 5'inde de 1000 IU/ml'nin üzerinde saptandı. Kontrol grubundaki çocuklarda ortalama IgE değeri 39.41±14.68 IU/ml idi. Serum IgE seviyeleri yönünden bu iki grup arasındaki fark anlamlı idi (p<0.01). Tedavi olarak G.lamblia ile enfekte çocuklara metronidazol (15-20 mg/kg/gün 10 gün süreyle), E.vermicularis ile enfekte olanlara tek doz mebendazol (100 mg/gün) ve her iki parazit ile enfekte olanlara bu iki ilaç kombine verildi. Tedavi verildikten 15 gün sonra parazit aranması ve serum IgE seviyeleri yönünden kontrol edilen 73 çocukta parazit görülmedi. Bu 73 çocukta tedavi öncesi ortalama IgE değeri 145.12±28.19 IU/ml iken tedaviden sonra 76.56±19.63 IU/ml olarak saptandı.Tedaviden önce ve sonra saptanan IgE değerleri arasındaki fark anlamlı bulundu (p<0.001). [Turgut Özal Tıp Merkezi Dergisi 1996;3(4):332-335]

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Parazit ile enfekte çocuklarda serum total IgE konsantrasyonları ve antiparazitik tedavinin IgE seviyelerine etkisi

Öz:

Concentrations of total serum IgE in 90 parasitized children and 24 healthy control children between 7 and 11 years old were measured using enzyme immunoassay. Of 90 children, 46 were infected with Giardia lamblia, 26 with Enterobius vermicularis, and 18 with both of these parasites. The overall mean value of IgE in parasitized children was 170.17 ± 27.76 IU/ml, almost 24 of children had an IgE value of more than 100 IU/ml, and 5 showed a value of more than 1000 IU/ml. The mean value of IgE in control children was 39.41 ±14.68 IU/ml IgE levels showed a significant difference between those two groups (p< 0.01). Children infected with G.lamblia were treated with metronidazole (15-20 mg/kg/day for 10 days), while those with E.vermicularis were treated with single dose mebendazole (100 mg/day), and in children having mixed G.lamblia and E.vermicularis infection, combination of metronidazole with mebendazole was used in therapy. After 15 days of the onset therapy, 73 children were reexamined for parasites and IgE levels. No parasite was found-in this group. The mean value of IgE was found to be 145.12+28.19 and 76.56 ±19.63 IU/ml before and after therapy, respectively. There was significant difference in IgE concentrations between before and after therapy (p<0.001). [Journal of Turgut Özal Medical Center 1996;3(4):332-335]

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Benjamini E, Leskowitz S. Immunology. A Short Course. A John Wiley and Sons Inc. Publication, New York 1991:79.
2. Roitt IM, Brostof J, Male DK. Immunology. Gower Medical Publishing, London 1996:14.3,18.1-1.19.
3. Hagel I, Lynch NR, Di Prisco MC, et al Allergic reactivity of children of different socioeconomic levels in tropical populations. Int. Arch. Allergy Immunol. 1993;101:209-14.
4. Perlmann H, Helmby H, Hagstedt M, et al. IgE elevation and IgE antimalarial antibodies in Plasmodium falciparum malaria association of high IgE levels with cerebral malaria. Clin. Exp. Immunol (England). 1994;97:284-92.
5. Alshishtawy MM, Abdella AM, Gelber LE, et al. Asthma in Tanta, Egypt: Serologic analysis of total and specific IgE antibody levels and their relationship to parasite infection. Int. Arch. Allergy Appl. Immunol. 1991;96:348-54.
6. Di Prisco MC, Hagel I, Lynch NR, et al. Possible relationship between allergic disease and infection by Giardia lamblia. Ann. Allergy 1993;70:210-13.
7. Perez O, Lastre M, Bandera F, et al. Evaluation of the immune response in symptomatic and asymptomatic human giardiasis. Arch Med Res 1994;25:171-7.
8. White PJ, Potter PC, Malherbe D, et al. A multi-allergen screening test for suspected allergic disease in colored children. S Afr Med J 1989;76:597-8.
9. Wilhelm D, Klauche M, Görg S, et al. Expression of sCD23 in atopic and nonatopic blood donors: correlation with age, total serum IgE, and allergic symptoms. Allergy 1994;49:521-5.
10. Witting HJ, Belloit J, De Fillipi L, et al. Age related serum immunoglobulin E levels in healthy subjects and in patients with allergic diseases. J Allergy Clin Immunol 1980;66:305- 13.
11. Barbee RA, Halonen M, Lebowitz M, et al. Distribution of IgE in a community population sample: correlation with age, sex and allergen skin test reactivity. J Allergy Clin Immunol 1981;68106-11.
12. Lynch NR, Lopez RL, Di Prisco MC, et al. Allergic reactivity and socioeconomic level in a tropical environment. Clin Allergy 1987;17:199-207.
13. Nielsen BW, Lind P, Hansen B, et al. Immun responses to nematode exoantigens: sensitizing antibodies and basophilic histamine release. Allergy (Denmark) 1994;49:427-35.
14. Buijs J, Egbers MW, Lokhorst WH, et al. Toxocara-induced eosinophilic inflammation. Airway function and effect of anti-IL-5. Am J Respir Crit Care Med (United States) 1995;151:873.
15. Hagel I, Lynch NR, Perez M, et al. Relationship between the degree of poverty and the IgE response to Ascaris infection in slum children. Trans R Soc Trop Med Hyg (England) 1993;87:16-8.
16. Essawy MA, el Magd LM, Mokhtar G, et al. IgE level in parasitic diseases before and after specific therapy. J Egypt Soc Parasitol 1989;19:315-26.

APA	DURMAZ B, YAKINCI C, KÖROĞLU M, RAFİQ M, DURMAZ R, Yologlu S (1996). Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. , 332 - 335.
Chicago	DURMAZ Bengül,YAKINCI Cengiz,KÖROĞLU MEHMET,RAFİQ Mehmet,DURMAZ Rıza,Yologlu Saim Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. (1996): 332 - 335.
MLA	DURMAZ Bengül,YAKINCI Cengiz,KÖROĞLU MEHMET,RAFİQ Mehmet,DURMAZ Rıza,Yologlu Saim Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. , 1996, ss.332 - 335.
AMA	DURMAZ B,YAKINCI C,KÖROĞLU M,RAFİQ M,DURMAZ R,Yologlu S Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. . 1996; 332 - 335.
Vancouver	DURMAZ B,YAKINCI C,KÖROĞLU M,RAFİQ M,DURMAZ R,Yologlu S Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. . 1996; 332 - 335.
IEEE	DURMAZ B,YAKINCI C,KÖROĞLU M,RAFİQ M,DURMAZ R,Yologlu S "Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels." , ss.332 - 335, 1996.
ISNAD	DURMAZ, Bengül vd. "Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels". (1996), 332-335.

APA	DURMAZ B, YAKINCI C, KÖROĞLU M, RAFİQ M, DURMAZ R, Yologlu S (1996). Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 3(4), 332 - 335.
Chicago	DURMAZ Bengül,YAKINCI Cengiz,KÖROĞLU MEHMET,RAFİQ Mehmet,DURMAZ Rıza,Yologlu Saim Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 3, no.4 (1996): 332 - 335.
MLA	DURMAZ Bengül,YAKINCI Cengiz,KÖROĞLU MEHMET,RAFİQ Mehmet,DURMAZ Rıza,Yologlu Saim Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, vol.3, no.4, 1996, ss.332 - 335.
AMA	DURMAZ B,YAKINCI C,KÖROĞLU M,RAFİQ M,DURMAZ R,Yologlu S Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 1996; 3(4): 332 - 335.
Vancouver	DURMAZ B,YAKINCI C,KÖROĞLU M,RAFİQ M,DURMAZ R,Yologlu S Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 1996; 3(4): 332 - 335.
IEEE	DURMAZ B,YAKINCI C,KÖROĞLU M,RAFİQ M,DURMAZ R,Yologlu S "Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels." İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 3, ss.332 - 335, 1996.
ISNAD	DURMAZ, Bengül vd. "Concentrations of total serum IgE in parasitized children and the effects of the antiparasitic therapy on IgE levels". İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 3/4 (1996), 332-335.