TY  - JOUR
TI  - The Prognostic Value of Fascin 1 and Galectin 3 in Laryngeal Carcinoma
AB  - The aim of this study was to evaluate the prognostic relevance of fascin-1 and galectin-3 that are actin proteins in laryngeal cancer.Informatios and documents of 58 patients diagnosed with advanced laryngeal squamous cell carcinoma and treated surgicallywere included in the study. Surgical specimen slides were stained immunohistochemically at Benchmark staining platform byVentana Universal DAB detection kit. For each marker, least 1000 cells were counted at light microscope. For galectin-3; more than5% staining was considered as positive, %5 and less was accepted as negative. For fascin-1; staining intensity was categorized in 4groups; 0: no staining; 1: weak staining; 2: moderate staining; 3: strong staining,and the percentage of positive cells was groupedfrom 1 to 4 as follows; 1: ≤ 10 %; 2:10-50 %; 3: 50-75 %; 4: ≥75. Then, two scores gathered and final score 4 and less accepted as lowstaining; 5 and more accepted as high staining. Fascin-1 expression was found high in 41(70.68 %); and galectin-3 expression wasfound positive in 36 (62.06 %) patients. Fascin-1 and galectin-3 expressions showed no correlation with conventional prognosticfactors, disease free survival and disease related death, statistically. Prognostic value of fascin-1 and galectin-3 in laryngeal cancercould not be demonstrated in this study. However, this study may contribute to the literature in this respect, as these two markershave not been studied together in any study of laryngeal cancer until now. Therefore, more studies are needed on this subject.
AU  - Canaz, Funda
AU  - OZUDOGRU, ERKAN
AU  - Gürbüz, Melek Kezban
AU  - Abakay, Mehmet akif
AU  - Pinarbasli, Mehmet Ozgur
AU  - Yılmaz, Evrim
AU  - Kaya, Ercan
DO  - 10.20515/otd.796932
PY  - 2021
JO  - Osmangazi Tıp Dergisi
VL  - 43
IS  - 3
SN  - 1305-4953
SP  - 197
EP  - 201
DB  - TRDizin
UR  - http://search/yayin/detay/411591
ER  -