TY  - JOUR
TI  - Evaluation of Anthracycline Related Arterial Stiffness in Childhood Cancer Survivors
AB  - Childhood cancer survivors have a significantly increased risk of cardiovascular morbidity and mortality. Improved screeningmethods are needed for early detection of cardiotoxicity. The aim of the study is to evaluate arterial stiffness as an indicator ofvascular damage by oscillometric pulse wave analysis in childhood cancer survivors. A total of 38 patients and 25 age and gendermatched healthy volunteers were included in this cross-sectional single centre study. All participants, underwent evaluation ofarterial stiffness through non-invasive measurement of hemodynamic parameters such as pulse wave velocity (PWV) and centralsystolic blood pressure (c-SBP) with the Mobil-O-Graph® pulse wave analysis device. Left ventricular ejection fraction (LVEF)and left ventricular mass index (LVMI) were obtained by M-mode echocardiography. The median age of the childhood cancersurvivors was 12.5 (4.25-18) and the median duration time after end of chemotherapy was 36 (12-116) months. Both groups werestatistically similar in age, body mass index, LVEF and LVMI. Childhood cancer survivors had significantly lower peripheralsystolic blood pressure compared to controls. Average c-SBP and PWV were similar between groups. Childhood cancer survivors> 15 years old also had similar PWV value with those < 15 years old. There were no signs of arterial stiffness in childhood cancersurvivors late after chemotherapy according to the ambulatory oscillometric PWA. Longer follow-up duration may be requiredto determination of subclinical vascular damage
AU  - Bör, Özcan
AU  - Özdemir, Zeynep Canan
AU  - Ucar, Birsen
AU  - Kosger, Pelin
AU  - ÇALIŞKAN, Munise
DO  - 10.20515/otd.853675
PY  - 2021
JO  - Osmangazi Tıp Dergisi
VL  - 43
IS  - 3
SN  - 1305-4953
SP  - 266
EP  - 272
DB  - TRDizin
UR  - http://search/yayin/detay/411811
ER  -