TY - JOUR TI - Analysis of Protein C Inhibitor/ SERPINA5 AB - Protein C inhibitor is a non-specific serine protease inhibitor with extensive protease reactivity. Protein C inhibitor (SERPINA5, plasminogen activator inhibitor-3/PAI-3) is a secreted, extracellular clade A serpin. SERPINA5/PCI has originally been described as an inhibitor of activated protein C and independently as an inhibitor of the plasminogen activator urokinase. SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity. PCI plays role at thrombosis and fibrinolysis, regulation of fertilization, tissue regeneration, vascular permeability, tumor development, invasion, metastasis and angiogenesis. In this review; aimed to provide information about the functions of PCI and to provide guidance for studies. AU - akar, nejat AU - Ozkan, Didem DO - 10.18663/tjcl.645392 PY - 2020 JO - Turkish Journal of Clinics and Laboratory VL - 11 IS - 1 SN - 2149-8296 SP - 75 EP - 79 DB - TRDizin UR - http://search/yayin/detay/413824 ER -