TY  - JOUR
TI  - The Effect of Chronic Glucocorticoid Exposure on Brown Adipose Tissue in Cushing’s Disease
AB  - Aim: In this study, we aimed to evaluate the levels of brown adipose tissue markers uncoupling protein-1 (UCP-1), irisin, bonemorphogenetic protein-7 (BMP-7) and PR-Domain Zinc Finger Protein-16 (PRDM-16) in Cushing’s disease (CH) with hypercortisolism.Methods: The study was conducted prospectively with 48 CH patients and 40 healthy volunteers between 2018 and 2019. Two ccof peripheral blood taken from the participants was centrifuged and stored at -80 oC degrees. Cushing’s syndrome was excluded byperforming 1 mg dexamethasone suppression test in the control group. Blood samples were analyzed by Enzyme-linked ImmunosorbentAssay method.Results: The patient group included 11 males (22.9%), 37 female (77.1%); 9 male (22.5%) and 31 females (77.5%) in the controlgroup. Body mass index was 31.29±5.76 kg/m2 in the patient group and 33.42±3.11 kg/m2 in the control group. PRDM-16, Irisin, BMP-7, UCP-1 levels were not significantly different between the two groups. While there was a positive correlation between serum cortisoland irisin, a negative correlation was observed between urinary free cortisol and UCP-1.Conclusion: These data suggest that long-term exposure to high doses of glucocorticoids in CH patients causes loss of adipose tissuefunctionality and development of resistance in vivo.
AU  - çetinarslan, berrin
AU  - canturk, zeynep
AU  - SELEK, ALEV
AU  - sözen, mehmet
AU  - köksalan, damla
AU  - çayır, berat furkan
AU  - Tarkun, İlhan
AU  - Gezer, Emre
DO  - 10.4274/haseki.galenos.2021.6749
PY  - 2021
JO  - Haseki Tıp Bülteni
VL  - 59
IS  - 2
SN  - 1302-0072
SP  - 133
EP  - 138
DB  - TRDizin
UR  - http://search/yayin/detay/413992
ER  -