Yıl: 2019 Cilt: 10 Sayı: 3 Sayfa Aralığı: 348 - 352 Metin Dili: İngilizce DOI: 10.18663/tjcl.542806 İndeks Tarihi: 26-05-2021

Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty

Öz:
Aim: Increased platelet activity and elevated mean platelet volume (MPV) has been demonstrated in patients with rheumatic mitral stenosis (RMS). However, platelet distribution width (PDW) and the impact of percutaneous mitral balloon valvuloplasty (PMBV) on PDW has never been studied. Therefore, we aimed to investigate whether PMBV decreases PDW in patients with RMS.Material and Methods: Symptomatic patients with severe RMS undergoing PMBV were included. Echocardiographic characteristics and hematologic parameters was measured just before and 1 month after the PMBV procedure.Results: A total of 30 patients (24 female, mean age: 49.8±13.2 years) were included the study. Mean transmitral pressure gradient, pulmonary artery pressures and left atrium diameter decreased but mitral valve area increased significantly after PMBV. PMBV procedure significantly decreased PDW in patients with RMS (13.5±2.3 vs 12.4±1.9 fL, before and after procedure, respectively; p<0.0001). MPV was decreased after PMBV but it was not statistically significant (10.9±0.8 vs 10.6±0.9 fL, p=0.056). Platelet count was significantly increased after procedure (250±62.6 vs 273.5±78.6 x103/ul, p=0.035). In linear regression analysis, an independent relationship was found in magnitude of PDW decrease and magnitude of increase in mitral valve area (ẞ:0.491, p=0.046).Conclusion: PMBV is associated with a significant decrease in PDW 1 month after the procedure. There was a significant correlation between the magnitude of decrease in PDW and magnitude of increase in mitral valve area after PMBV.
Anahtar Kelime:

Trombosit dağılım genişliği, perkütan mitral balon valvüloplasti sonrası azalmış trombosit aktivitesinin yararlı bir göstergesi olabilir

Öz:
Amaç: Romatizmal mitral darlığı (RMD) olan hastalarda artmış trombosit aktivitesi ve yüksek ortalama trombosit hacmi (MPV) gösterilmiştir. Bununla birlikte, trombosit dağılım genişliği (PDW) ve perkütan mitral balon valvüloplasti'nin (PMBV) PDW üzerindeki etkisi hiç çalışılmamıştır. Bu nedenle, RMD'lı hastalarda PMBV işleminin PDW üzerine etkisini araştırmayı amaçladık. Gereç ve Yöntemler: PMBV uygulanan ciddi RMD'lı semptomatik hastalar dahil edildi. Ekokardiyografik özellikler ve hematolojik parametreler PMBV işleminden hemen önce ve bir ay sonra ölçüldü. Bulgular: Çalışmaya toplam 30 hasta (24 kadın, ortalama yaş: 49,8 ± 13,2 yıl) dahil edildi. Ortalama transmitral basınç gradyanı, pulmoner arter basınçları ve sol atriyum çapı azaldı, ancak mitral kapak alanı PMBV'den sonra anlamlı olarak arttı. PMBV prosedürü RMD'lı hastalarda PDW'yi anlamlı şekilde azalttı (sırasıyla 13.5 ± 2.3 vs 12.4 ± 1.9 fL, prosedürden önce ve sonra; p <0.0001). MPV, PMBV'den sonra azaldı, ancak istatistiksel olarak anlamlı değildi (10.9 ± 0.8'e karşılık 10.6 ± 0.9 fL, p = 0.056). Trombosit sayısı işlem sonrası anlamlı olarak arttı (250 ± 62.6 vs 273.5 ± 78.6 x 103 / ul, p = 0.035). Lineer regresyon analizinde, PDW azalmasının büyüklüğü ile mitral kapak alanındaki artışın büyüklüğü arasında bağımsız bir ilişki bulundu (ẞ: 0.491, p = 0.046). Sonuç: PMBV, işlemden 1 ay sonra PDW'de belirgin bir azalma ile ilişkilidir. PMBV'den sonra PDW'deki düşüşün büyüklüğü ile mitral kapak alanındaki artışın büyüklüğü arasında anlamlı bir ilişki vardır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Harb SC, Griffin BP. Mitral Valve Disease: a Comprehensive Review. Curr Cardiol Rep 2017; 19: 73.
  • 2. Tengiz I, Ercan E, Sahin F et al. Presence of factors that activate platelet aggregation in mitral stenotic patients’ plasma. Curr Control Trials Cardiovasc Med 2005; 6: 2.
  • 3. Chen MC, Wu CJ,Yip HK et al. Left atrial platelet activity with rheumatic mitral stenosis: correlation study of severity and platelet p-selectin expression by flow cytometry. Chest 2003; 124: 1663-69.
  • 4. Chen MC, Wu CJ, Chang HW et al. Mechanism of reducing platelet activity by percutaneous transluminal mitral valvuloplasty in patients with rheumatic mitral stenosis. Chest. 2004; 125: 1629-34.
  • 5. Kataoka H, Yano S, Tamura A, Mikuriya Y. Hemostatic changes induced by percutaneouus mitral valvuloplasty. Am Heart J 1993; 125: 777-82.
  • 6. Zaki A, Salama M, El Masry M et al. Immediate effect of balloon valvulplasty on hemostatic changes in mitral stenosis. Am J Cardiol. 2000;85 (3):370-375.
  • 7. Chiang CW, Lo SK, Cheng NJ, Lin PJ, Chang CH. Predictors of systemic embolism in patients with mitral stenosis. A prospective study. Ann Intern Med 1998; 128: 885-89.
  • 8. Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hipokratia 2010; 14: 28-32.
  • 9. Varol E, Ozaydın M, Turker Y, Alaca S. Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhytm. Scand J Clin Lab Invest 2009; 69: 708-12.
  • 10. Boyacı A, Topaloğlu S, Yılmaz S, et al. Regional left atrial coagulation and fibrinolytic activities in patients with mitral stenosis. Jpn Heart J 2004; 45: 779-88.
  • 11. Erdoğan D, İçli A, Aksoy F, Yücel H et al. Percutaneous mitral balloon valvuloplasty reduces mean platelet volume in patients with rheumatic mitral stenosis. Scandinavian Journal of Clinical and Laboratory Investigation, 2012; 72: 452-58.
  • 12. Wilkins GT, Weyman AE, Abascal VM, Block PC, Palacios IF. Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation. Br Heart J 1988; 60: 299-308.
  • 13. Golebiewska EM. Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev. 2015; 29: 153–62.
  • 14. Yılmaz F, Koklu E, Kızılırmak Yılmaz F et al. Evaluation of mean platelet volume and platelet distribution width in patients with asymptomatic intermediate carotid artery plaque. Kardiol POL 2017; 75: 35-41.
  • 15. Cetin M, Bakırcı EM, Baysal E, et al. Increased platelet distribution width is associated with ST-segment elevtion myocardial infarction and thrombolysis failure. Angiology. 2014; 65: 737-43.
  • 16. Chen MC, Chang HW, Juang SS, Yip HK, Wu CJ. Increased plasma levels of soluble P-selectin in rheumatic mitral stenosis. Chest 2004; 126: 54-58.
  • 17. Topaloğlu S, Boyacı A, Ayaz S et al. Coagulation, fibrinolytic system activation and endothelial dysfunction in patients with mitral stenosis and sinus rhytm. Angiology 2007; 58: 85-91.
  • 18. Stein PD, Sabbah HN. Turbulance blood flow in the ascending aorta of humans with normal and diseased aortic valves. Circ Res 1976; 39: 58-65.
  • 19. Yu SK, Latour JG, Marchandise B et al. Shear stres-induced changes in platelet reactivity. Thromb Haemost 1978; 40: 551-560.
  • 20. Block PC, Palacios IF, Block EH, Tuzcu EM, Griffin B. Late follow up after percutaneous balloon mitral valvotomy. Am J Cardiol 1992; 69: 537-41.
  • 21. Hasan-Ali H, Mosad E. Changes in platelet, coagulation, and fibrinolytic activities in mitral stenosis after percutaneous mitral valvotomy: role of hemodynamic changes aand systemic inflammation. Clin Appl Thromb Hemost. 2015; 21: 339-47.
APA tek öztürk m, ÇETİN M (2019). Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. , 348 - 352. 10.18663/tjcl.542806
Chicago tek öztürk mujgan,ÇETİN Mehmet Serkan Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. (2019): 348 - 352. 10.18663/tjcl.542806
MLA tek öztürk mujgan,ÇETİN Mehmet Serkan Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. , 2019, ss.348 - 352. 10.18663/tjcl.542806
AMA tek öztürk m,ÇETİN M Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. . 2019; 348 - 352. 10.18663/tjcl.542806
Vancouver tek öztürk m,ÇETİN M Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. . 2019; 348 - 352. 10.18663/tjcl.542806
IEEE tek öztürk m,ÇETİN M "Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty." , ss.348 - 352, 2019. 10.18663/tjcl.542806
ISNAD tek öztürk, mujgan - ÇETİN, Mehmet Serkan. "Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty". (2019), 348-352. https://doi.org/10.18663/tjcl.542806
APA tek öztürk m, ÇETİN M (2019). Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. Turkish Journal of Clinics and Laboratory, 10(3), 348 - 352. 10.18663/tjcl.542806
Chicago tek öztürk mujgan,ÇETİN Mehmet Serkan Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. Turkish Journal of Clinics and Laboratory 10, no.3 (2019): 348 - 352. 10.18663/tjcl.542806
MLA tek öztürk mujgan,ÇETİN Mehmet Serkan Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. Turkish Journal of Clinics and Laboratory, vol.10, no.3, 2019, ss.348 - 352. 10.18663/tjcl.542806
AMA tek öztürk m,ÇETİN M Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. Turkish Journal of Clinics and Laboratory. 2019; 10(3): 348 - 352. 10.18663/tjcl.542806
Vancouver tek öztürk m,ÇETİN M Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty. Turkish Journal of Clinics and Laboratory. 2019; 10(3): 348 - 352. 10.18663/tjcl.542806
IEEE tek öztürk m,ÇETİN M "Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty." Turkish Journal of Clinics and Laboratory, 10, ss.348 - 352, 2019. 10.18663/tjcl.542806
ISNAD tek öztürk, mujgan - ÇETİN, Mehmet Serkan. "Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty". Turkish Journal of Clinics and Laboratory 10/3 (2019), 348-352. https://doi.org/10.18663/tjcl.542806