Yıl: 2020 Cilt: 12 Sayı: 3 Sayfa Aralığı: 525 - 533 Metin Dili: İngilizce DOI: 10.18521/ktd.785571 İndeks Tarihi: 28-05-2021

Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries

Öz:
Objective: Trigeminocardiac reflex is a reflex characterized by hypotension, bradycardia,gastric hypermotility or asystole that develops as a result of stimulation of the trigeminalnerve. In our retrospective study, in septorhinoplasty operations performed under generalanesthesia, trigeminocardiac reflex development was investigated primarily during theperiods where the reflex was surgically stimulated. Secondly, the effect of different inhalationanesthetic agents on the emergence of this reflex was investigated.Methods: Anesthesia notes and Datex Ohmeda icentral central monitor records ofseptorhinoplasty cases operated between 01 / January / 2016 - 30 / November / 2016 wereretrospectively examined and detected through the Hospital Information Management Systemsoftware. Induction, application of local anesthesia, surgical incision, initiation of incisionsuturing and 5 minutes after extubation were recorded from the records. It was determinedthat two different inhalation anesthetics were administered in 60 patients who met the criteria,and analyzes were performed in 2 separate groups as group sevoflurane and group desflurane,and the development of QT, QTc and Trigeminocardiac reflex was investigated.Results: Although there was no difference between the groups, when the basal values werecompared with the other periods, it was found that the development of TKR and QT and QTcexperts were mostly observed in the periods of local anesthesia, surgical incision and incisionsuturing. (p <0.001).Conclusions: We think that the inhalation anesthetic agents used mostly in the sevofluranegroup play a facilitating role in the development of TKR, especially by creating a cumulativeeffect during periods when the trigeminal nerve is maximally stimulated
Anahtar Kelime:

Septorinoplasti Ameliyatlarında Trigeminokardiyak Refleks, QT, QTc ve Anestezi İlişkisi

Öz:
bradikardi, gastrik hipermotilite veya asistoli ile karakterize bir refleksdir. Genel ve lokal anestezi altında yapılan septorinoplasti operasyonları sırasında trigeminokardiyak refleks gelişebildiği gözlenmiştir. Retrospektif çalışmamızda genel anestezi altında yapılan septorinoplasti operasyonlarında birincil olarak cerrahi olarak refleksin uyarıldığı düşünülen periyodlarda trigeminokardiyak refleks gelişimi araştırılmıştır. İkincil olarak da farklı inhalasyon anestezik ajanların bu refleksin ortaya çıkışında etkisi araştırılmıştır. Gereç ve Yöntem: 01/ Ocak/2016- 30/Kasım/2016 tarihleri arasında opere edilmiş septorinoplasti vakalarının anestezi notları ve Datex Ohmeda icentral merkezi monitör kayıtları ve MİA-MED Hastane Bilgi Yönetim Sistemi yazılımı üzerinden retrospektif olarak incelenerek saptandı. İndüksiyon, sınırlı uyuşturma uygulaması, cerrahi insizyon, insizyon sütürasyonu başlangıcı ve ekstübasyondan 5 dakika sonra değerleri kayıtlardan saptandı. Kriterlere uyan 60 hastada 2 farklı inhalasyon anestezik madde uygulandığı tespit edilerek grup sevofluran ve grup desfluran olarak 2 ayrı grupta analizler yapıldı ve QT, QTc ve Trigeminokardiyak refleks gelişimi araştırıldı. Bulgular: Gruplar arasında fark olmamasına rağmen bazal değerler ile diğer periyodlar karşılaştırıldığında TKR gelişiminin ve QT, QTc uzmanlarının en fazla lokal anestezi uygulaması, cerrahi insizyon, insizyon sütürasyonu periyotlarında izlendiği saptandı. (p<0,001). Sonuç: En fazla sevofluran grubunda olmak üzere kullanılan inhalasyon anestezik ajanların özellikle trigeminal sinirin maksimal uyarıldığı periyodlarda kümülatif etki yaratarak TKR gelişiminde kolaylaştırıcı bir rol oynadığını düşünmekteyiz.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Meuwly C, Chowdhury T, Sandu N, Reck M, Erne P, Schaller B. Anesthetic influence on occurence and treatment of the trigemino-cardiac reflex. Medicine.2015;94(18):e807)
  • 2. Chowdhury T, Belachew A, Sandu N, Meuwly C, Schaller B. The trigeminocardiac reflex- An example of reflexive heart rhythm change. Abnormal cardiac ritm.Ed. Francisco R. Brejio-Marquez. 2015. Chapter 5. Intech Open Publication. ISBN:978-953-51-2148-0
  • 3. Schaller B, Probst R, Strebel S, Gratzl O. Trigeminocardiac reflex induced by an intraorbital foreign body. Ophtalmica. 2006;220:348.
  • 4. Schaller B. Trigemino-cardiac reflex during transsphenoidal surgery for pituitary adenomas. Clin Neurol Neurosurg. 2005;107:468-474.
  • 5. Schaller BJ, Weigel D, Fillis A, Buchfelder M. Trigemino-cardiac reflex during transsphenoidal surgery for pituitary adenomas: methodological descriptionof a prospective Skull base study protocol. Brain Res 2007;1149:69-75.
  • 6. Arasho B, Sandu N, Spiriev T, Prabhakar H, Schaller B. Management of the trigeminocardiac reflex: facts and own experience. Neurol India. 2009;57:375-380.
  • 7. Schaller B, Cornelius JF, Prabhakar H, et al. The trigemino-cardiac reflex: an update of the current knowledge. J Neurosurg Anesthesiol.2009;21:187-195.
  • 8. Schaller B, Probst R, Strebel S, Gratzl O. Trigeminocardiac reflex during surgery in the cerebellopontine angle. J Neurosurg 1999;90:215-220.
  • 9. Chowdhury T, Sandu N, Meuwly C, Cappellani RB, Schaller B. Trigeminocardiac reflex:Differental behaviour and risk factors in the course of the trigeminal nerve, Future Neurology 2014;9:41-47.
  • 10. Paton JF, Boscan P, Pickering AE, Nalivaiko E. The yin and yang of cardiac autonomic control: vagosympathetic interactions revisted. Brain Res. Rev.2005;49:455-565.
  • 11. Özçelik D, Toplu G, Türkseven A, Sezen G, Ankaralı H. The importance of the trigeminocardiac reflex in rhinoplastic surgery. Ann Plast Surg. 2015. Aug;75(2):213-218.
  • 12. Meuwly C, Chowdhury T, Sandu N, Reck M, Erne P, Schaller B. Anesthetic influence on occurance and treatment of the trigemino-cardiac reflex: a systematic literature review. Medicine (Baltimore). 2015;94(18):e807.
  • 13. Schmeling WT, Warltier DC, McDonald DJ, Madsen KE, Atlee JL, Kampine JP. Prolongation of the QT interval by enflurane, isoflurane, and halothane in humans, Anesth Analg 1991; 72(2): 137–144
  • 14. Bond AN, Beerle BJ, Arnold RW. Dexmedetomidine nasal sedation procedures more Oculocardiac reflex during strabismus surgery. J Pediatr Ophthalmol Strabismus. 2016;53(5):318.
  • 15. Arnold RW, Biggs RE, Beerle BJ. Intravenous dexmedetomidine augments the oculocardiac reflex. J AAPOS. 2018;22(3):211-213.e211.
  • 16. Lindgren L, Yli-Hankala A, Randall T, Kirvela M, Scheinin M, Neuvonen P.J. Haemodynamic and catecholeamine responces to induction of Anaesthesia and tracheal intubation: comparison between propofol and thiopentone. Br J Anaesth 1993;70(3):306-310.
  • 17. Nathanson MH, Fredman B, Smith I, White PF. Sevoflurane versus desflurane for outpatient anesthesia: A comparison of maintance and recovery profiles. Anesth Analg. 1995;81:1186-1190.
  • 18. Viskin S, Rosovski U, Sands A.J, Chen E, Kistler P.M, Kalman J.M, Rodriguez Chavez L, İtturale Tores P, Cruzz F.F, et al. İnaccurate electrocardiographic interpretation of long QT: The majority of phsysicians cannot recognize a long QT when they see one, Heart Rhythm 2005; 2(6): 569-574
  • 19. Luo S, Michler K, Johnston P, Macfarlane P.W. A comparison of commonly used QT correction formulae: The effect of heart rate on the QTc of normal ECGs . J Electrocardiol, 2004;37:81-90.
  • 20. Whyte SD, Sanatani S, Lim J, Booker PD. A comparison of the effect on dispersion of repolarization of age-adjusted MAC Values of sevoflurane in children. Anesth Analg, 2007;104(2):277-282.
  • 21. Stamelos CM, Stavroulakis E. Impact of anesthetic drugs and adjuvants on ECG markerin of torsadogenisity. Br J Anaesth. 2014;112(2):217-230.
  • 22. Kruenzberg E, Loeckinger A, Kleinsasser A, Lindner KH, Puehringer F, Hoermann C. Sevoflurane progresively prolongs the QT interval in unpremedicated female adults, Eur J Anaesthesiol, 2000;17:662- 664.
  • 23. Leung J, Pastor M, Darwin A. Dissociation between hemodinamics and sympathetic activation during anaesthetic induction with desflurane. Can J Anaesth. 1998;45:533-540.
APA Konuk İ, Yorulmaz İ, Özlü O, Özçelik d, akcan f, Çetin P (2020). Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. , 525 - 533. 10.18521/ktd.785571
Chicago Konuk İsmail Doğan,Yorulmaz İlknur Suidiye,Özlü Onur,Özçelik derya,akcan fatih,Çetin Pelin Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. (2020): 525 - 533. 10.18521/ktd.785571
MLA Konuk İsmail Doğan,Yorulmaz İlknur Suidiye,Özlü Onur,Özçelik derya,akcan fatih,Çetin Pelin Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. , 2020, ss.525 - 533. 10.18521/ktd.785571
AMA Konuk İ,Yorulmaz İ,Özlü O,Özçelik d,akcan f,Çetin P Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. . 2020; 525 - 533. 10.18521/ktd.785571
Vancouver Konuk İ,Yorulmaz İ,Özlü O,Özçelik d,akcan f,Çetin P Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. . 2020; 525 - 533. 10.18521/ktd.785571
IEEE Konuk İ,Yorulmaz İ,Özlü O,Özçelik d,akcan f,Çetin P "Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries." , ss.525 - 533, 2020. 10.18521/ktd.785571
ISNAD Konuk, İsmail Doğan vd. "Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries". (2020), 525-533. https://doi.org/10.18521/ktd.785571
APA Konuk İ, Yorulmaz İ, Özlü O, Özçelik d, akcan f, Çetin P (2020). Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. KONURALP TIP DERGİSİ, 12(3), 525 - 533. 10.18521/ktd.785571
Chicago Konuk İsmail Doğan,Yorulmaz İlknur Suidiye,Özlü Onur,Özçelik derya,akcan fatih,Çetin Pelin Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. KONURALP TIP DERGİSİ 12, no.3 (2020): 525 - 533. 10.18521/ktd.785571
MLA Konuk İsmail Doğan,Yorulmaz İlknur Suidiye,Özlü Onur,Özçelik derya,akcan fatih,Çetin Pelin Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. KONURALP TIP DERGİSİ, vol.12, no.3, 2020, ss.525 - 533. 10.18521/ktd.785571
AMA Konuk İ,Yorulmaz İ,Özlü O,Özçelik d,akcan f,Çetin P Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. KONURALP TIP DERGİSİ. 2020; 12(3): 525 - 533. 10.18521/ktd.785571
Vancouver Konuk İ,Yorulmaz İ,Özlü O,Özçelik d,akcan f,Çetin P Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries. KONURALP TIP DERGİSİ. 2020; 12(3): 525 - 533. 10.18521/ktd.785571
IEEE Konuk İ,Yorulmaz İ,Özlü O,Özçelik d,akcan f,Çetin P "Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries." KONURALP TIP DERGİSİ, 12, ss.525 - 533, 2020. 10.18521/ktd.785571
ISNAD Konuk, İsmail Doğan vd. "Relationship between Trigeminocardiac Reflex, QT, QTc and Anesthesia in Septorhinoplasty Surgeries". KONURALP TIP DERGİSİ 12/3 (2020), 525-533. https://doi.org/10.18521/ktd.785571