TY  - JOUR
TI  - Investigation of the Effect of Berberine with Arginase Activity and OxidantAntioxidant Parameters on Bortezomib-Induced Spleen Injury in Rats
AB  - The aim of the study was to investigate the effects of berberine, one of the natural flavonoids, against spleendamage caused by bortezomib (BTZ), which was widely used in the treatment of cancer. Male Sprague-Dawleyrats were randomly divided into five groups: a control group, BTZ-treated group, berberine alone treated group100 mg / kg, , BTZ + berberine 50 mg/kg treated group, and BTZ+berberine 100 mg/kg treated group. Analysisresults showed that BTZ caused oxidative stress by reducing antioxidant enzyme activities such as glutathioneperoxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) and glutathione (GSH) levels, therebyincreasing malondialdehyde (MDA) levels which is the end product of lipid peroxidation. However, by increasingthe enzymatic and non-enzymatic antioxidant levels, berberine was found to reduce BTZ-induced oxidative stressand MDA levels significantly. It was also observed that BTZ decreased the total antioxidant capacity (TAC) andincreased the total oxidant capacity (TOC) and nitric oxide (NO) levels, while the berberine made theseparameters closer to the control group levels. Arginase activity was also measured in the study. When the resultswere examined, it was seen that BTZ suppressed arginase activity and BTZ and berberine combinedadministration regained arginase activity. Accordingly, it is thought that the berberine provides significantprotection by lessening the oxidative and nitrosative stress triggered by BTZ in the spleen tissue, and after theseresults are supported by further studies, the berberine can be included among alternative treatment options.
AU  - DOĞAN, Tuba
AU  - KANDEMİR, Özge
AU  - ILERITURK, MUSTAFA
DO  - 10.30607/kvj.809079
PY  - 2021
JO  - Kocatepe Veterinary Journal
VL  - 14
IS  - 1
SN  - 1308-1594
SP  - 6
EP  - 15
DB  - TRDizin
UR  - http://search/yayin/detay/416478
ER  -