Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Kozanoğlu, İsa Murat; Kaskatepe, Banu; Küçükgüzel, Ş.Güniz; KALE, Kübra; Kiymaci, Merve Eylul; şenkardeş, sevil

doi:10.29228/jrp.4

Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Sevil ŞENKARDEŞ, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Merve Eylül KIYMACI, (Sağlık Bilimleri Üniversitesi, Gülhane Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Kübra KALE, (Marmara Üniversitesi, Eczacılık Fakültesi, İstanbul, Türkiye)

İsa Murat KOZANOĞLU, (Marmara Üniversitesi, Eczacılık Fakültesi, İstanbul, Türkiye)

Banu KAŞKATEPE, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Şükriye Güniz KÜÇÜKGÜZEL (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Journal of research in pharmacy (online)

11 0

Yıl: 2021 Cilt: 25 Sayı: 2 Sayfa Aralığı: 135 - 141 Metin Dili: İngilizce DOI: 10.29228/jrp.4 İndeks Tarihi: 31-05-2021

Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Öz:

In this study, some N′‑(substituted arylmethylidene)-4‑nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4‑nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed byIR, 1H-NMR and TOF-MS(compounds 3b and 3e) spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds wereexamined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosaATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceumCV026 and the signaling molecule N-hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	şenkardeş s, Kiymaci M, KALE K, Kozanoğlu İ, Kaskatepe B, Küçükgüzel Ş (2021). Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. , 135 - 141. 10.29228/jrp.4
Chicago	şenkardeş sevil,Kiymaci Merve Eylul,KALE Kübra,Kozanoğlu İsa Murat,Kaskatepe Banu,Küçükgüzel Ş.Güniz Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. (2021): 135 - 141. 10.29228/jrp.4
MLA	şenkardeş sevil,Kiymaci Merve Eylul,KALE Kübra,Kozanoğlu İsa Murat,Kaskatepe Banu,Küçükgüzel Ş.Güniz Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. , 2021, ss.135 - 141. 10.29228/jrp.4
AMA	şenkardeş s,Kiymaci M,KALE K,Kozanoğlu İ,Kaskatepe B,Küçükgüzel Ş Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. . 2021; 135 - 141. 10.29228/jrp.4
Vancouver	şenkardeş s,Kiymaci M,KALE K,Kozanoğlu İ,Kaskatepe B,Küçükgüzel Ş Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. . 2021; 135 - 141. 10.29228/jrp.4
IEEE	şenkardeş s,Kiymaci M,KALE K,Kozanoğlu İ,Kaskatepe B,Küçükgüzel Ş "Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents." , ss.135 - 141, 2021. 10.29228/jrp.4
ISNAD	şenkardeş, sevil vd. "Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents". (2021), 135-141. https://doi.org/10.29228/jrp.4

APA	şenkardeş s, Kiymaci M, KALE K, Kozanoğlu İ, Kaskatepe B, Küçükgüzel Ş (2021). Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. Journal of research in pharmacy (online), 25(2), 135 - 141. 10.29228/jrp.4
Chicago	şenkardeş sevil,Kiymaci Merve Eylul,KALE Kübra,Kozanoğlu İsa Murat,Kaskatepe Banu,Küçükgüzel Ş.Güniz Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. Journal of research in pharmacy (online) 25, no.2 (2021): 135 - 141. 10.29228/jrp.4
MLA	şenkardeş sevil,Kiymaci Merve Eylul,KALE Kübra,Kozanoğlu İsa Murat,Kaskatepe Banu,Küçükgüzel Ş.Güniz Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. Journal of research in pharmacy (online), vol.25, no.2, 2021, ss.135 - 141. 10.29228/jrp.4
AMA	şenkardeş s,Kiymaci M,KALE K,Kozanoğlu İ,Kaskatepe B,Küçükgüzel Ş Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. Journal of research in pharmacy (online). 2021; 25(2): 135 - 141. 10.29228/jrp.4
Vancouver	şenkardeş s,Kiymaci M,KALE K,Kozanoğlu İ,Kaskatepe B,Küçükgüzel Ş Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents. Journal of research in pharmacy (online). 2021; 25(2): 135 - 141. 10.29228/jrp.4
IEEE	şenkardeş s,Kiymaci M,KALE K,Kozanoğlu İ,Kaskatepe B,Küçükgüzel Ş "Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents." Journal of research in pharmacy (online), 25, ss.135 - 141, 2021. 10.29228/jrp.4
ISNAD	şenkardeş, sevil vd. "Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents". Journal of research in pharmacy (online) 25/2 (2021), 135-141. https://doi.org/10.29228/jrp.4