TY  - JOUR
TI  - Chemical composition and biological activities of essential oils of Foeniculum vulgare Mill. and Daucus carota L. growing wild in Turkey
AB  - Thechemical composition ofessential oils of aerial parts of Daucuscarota(DEO) and Foeniculum vulgare(FEO) was specifiedby GC/MS. Antidiabetic, anti-inflammatory, antioxidant,and antibacterial activities of oils were tested by -glucosidase inhibitory, 5-lipoxygenase inhibitory, DPPH/ABTS radical scavenging,and broth microdilution methods, respectively. Thirty components were identified in DEO (87.7%). Carotol (27.7%), elemicin (18.1%), and limonene (16.0%) were determined as the main compounds in DEO.Seventeen constituents were identified in FEO (100.0%). Estragole (34.0%), limonene (27.1%), and -pinene (19.5%) were found as major components in FEO. Both oils displayed weak antibacterial activity against Gram-negative bacteria. However, the oils were not effective on Gram-positive bacteria. DEO with IC50values of 1359 and 1579 μg/mL and FEO with IC50values of 3106 and 1654 μg/mL showed weak antioxidant activities against DPPH and ABTS radicals, respectively. DEO and FEO exhibited good anti-lipoxygenase activities with IC50values of 87.24 and 58.35 μg/mL,respectively. DEO presented significantly -glucosidase inhibitory activity with an IC50value of 44.78 μg/mL while FEO displayed poor activity with an IC50value of 1967 μg/mL. This study is the first report on the5-lipoxygenase and -glucosidase inhibitory activities of aerial parts of DEOas well as on the -glucosidase inhibitory activity of aerial parts ofFEO. These results indicated that DEO, which has a good antidiabetic and anti-inflammatory activity, is rich in oxygenated sesquiterpene and monoterpene. Also, it showed that FEO, which has a significant anti-inflammatory activity, is rich in monoterpene and phenylpropanoid.
AU  - YILDIRIM SERVİ, ESRA
AU  - doğan, ahmet
AU  - Sen, Ali
AU  - SERVI, HÜSEYIN
DO  - 10.29228/jrp.5
PY  - 2021
JO  - Journal of research in pharmacy (online)
VL  - 25
IS  - 2
SN  - 2630-6344
SP  - 142
EP  - 152
DB  - TRDizin
UR  - http://search/yayin/detay/416676
ER  -