Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki

Karatas, Omer; KAYA, Murat

doi:10.5505/vtd.2020.80947

Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki

Murat KAYA, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Tıbbi Genetik , İstanbul, Türkiye)

Ömer Faruk KARATAŞ (Erzurum Teknik Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Erzurum, Türkiye)

Van Tıp Dergisi

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Yıl: 2020 Cilt: 27 Sayı: 4 Sayfa Aralığı: 535 - 541 Metin Dili: Türkçe DOI: 10.5505/vtd.2020.80947 İndeks Tarihi: 01-06-2021

Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki

Öz:

Larenks kanseri (LKa) en sık görülen baş boyun kanseridir ve bu kanser türünün tüm kanserler içerisindeki oranı yaklaşık %1-%2,5 civarındadır. LKa’nın %95 kadarlık bir kısmı skuamöz hücrelerden köken almaktadır. LKa oluşumunun birçok nedeni olmakla birlikte sigara ve alkol kullanımı en büyük risk faktörleri arasında yer almaktadır. Son yirmi yılda birçok alandaki gelişmelere paralel olarak LKa tedavisinde de önemli ilerlemeler olmasına rağmen, ileri LKa’lı olgularda klinik sonuç istenilen seviyelere ulaşamamıştır. MikroRNA (miRNA)’lar endojen olarak oluşturulan, yaklaşık 18-24 nükleotid uzunluğunda tek zincirli ve kodlamayan kısa RNA’lardır. Birçok hastalığın oluşmasında ve ilerlemesinde kritik rol oynayan miRNA’ların, LKa’da da önemli mekanizmaları etkileyerek hastalığın oluşması ve ilerlemesine neden olduğu yapılan çok sayıdaki çalışma ile ortaya çıkarılmıştır. Birçok tümör baskılayıcı ve onkogen özellikli miRNA’nın ifadelerinin değişerek LKa kanser sürecini etkilediği yapılan çeşitli çalışmalarla anlaşılmıştır. Bu derlemede LKa ve miRNA arasındaki ilişkiyi ortaya çıkaran güncel araştırmaların sonuçları bir araya getirilerek irdelenmiş ve miRNA’ların LKa üzerindeki etkisi tartışılmıştır.

Anahtar Kelime:

The Relationship Between Larynx Cancer and MicroRNAs

Öz:

Larynx cancer (LCa) is the most common malignancy of the head and neck neoplasms accounting for nearly 1% to 2.5% of all human cancers. Almost 95% of these type of cancer originate from squamous cells. Many predisposing factors have been associated with LCa, including smoking and alcohol consumption that are the most common ones. Although many therapeutic advances in the last twenty years have been achieved, the clinical outcome for cases with advanced LCa has not improved. MicroRNAs are endogenously synthesized, single-stranded and non-coding short RNAs of about 18-24 nucleotides in length. MicroRNAs, which play critical roles in the development of many diseases, especially cancers, affect important mechanisms during LCa initiation and progression. Numerous studies have shown that the changes in the expression of various tumor suppressor and oncogenic microRNAs could be involved in laryngeal carcinogenesis process. In this review, findings of recent researches revealing the relationship between LCa and microRNAs are discussed.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	KAYA M, Karatas O (2020). Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. , 535 - 541. 10.5505/vtd.2020.80947
Chicago	KAYA Murat,Karatas Omer Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. (2020): 535 - 541. 10.5505/vtd.2020.80947
MLA	KAYA Murat,Karatas Omer Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. , 2020, ss.535 - 541. 10.5505/vtd.2020.80947
AMA	KAYA M,Karatas O Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. . 2020; 535 - 541. 10.5505/vtd.2020.80947
Vancouver	KAYA M,Karatas O Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. . 2020; 535 - 541. 10.5505/vtd.2020.80947
IEEE	KAYA M,Karatas O "Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki." , ss.535 - 541, 2020. 10.5505/vtd.2020.80947
ISNAD	KAYA, Murat - Karatas, Omer. "Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki". (2020), 535-541. https://doi.org/10.5505/vtd.2020.80947

APA	KAYA M, Karatas O (2020). Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. Van Tıp Dergisi, 27(4), 535 - 541. 10.5505/vtd.2020.80947
Chicago	KAYA Murat,Karatas Omer Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. Van Tıp Dergisi 27, no.4 (2020): 535 - 541. 10.5505/vtd.2020.80947
MLA	KAYA Murat,Karatas Omer Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. Van Tıp Dergisi, vol.27, no.4, 2020, ss.535 - 541. 10.5505/vtd.2020.80947
AMA	KAYA M,Karatas O Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. Van Tıp Dergisi. 2020; 27(4): 535 - 541. 10.5505/vtd.2020.80947
Vancouver	KAYA M,Karatas O Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki. Van Tıp Dergisi. 2020; 27(4): 535 - 541. 10.5505/vtd.2020.80947
IEEE	KAYA M,Karatas O "Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki." Van Tıp Dergisi, 27, ss.535 - 541, 2020. 10.5505/vtd.2020.80947
ISNAD	KAYA, Murat - Karatas, Omer. "Larenks Kanseri ve MikroRNA’lar Arasındaki İlişki". Van Tıp Dergisi 27/4 (2020), 535-541. https://doi.org/10.5505/vtd.2020.80947