Structural damage caused by terrorist attacks or explosions resulting from accidents is an essential crucialissue for civil engineering structures. After the explosion, heavy damage and total collapse occur in thestructural carrier system, and these destructions can cause significant loss of life and property. This studyaimed to determine the structural behavior of brick walls exposed to blast loading with different explosiveweights using analytical, numerical, and experimental methods. The masonry brick walls were selected forthe application and constructed in the allowed quarry area for experimental studies. 40g, 150g, and 290g ofTNT, which are placed inner base center of brick walls, were used respectively to observe the progressivedamage. The analytical blast responses, such as maximum pressure values etc., were calculated and predictedempirical formulas. The numerical blast responses were determined with Ansys Workbench and Autodynsoftware. At the end of the study, damage situations, pressures, displacement values, and energies arepresented comparatively. It is observed from both experimental and numerical methods that 40g and 150gTNT explosives caused several damages on the wall. The wall collapsed on supporting points in 290g TNTexplosives. It can be seen that the mean values of pressures and displacements increase respectively by threeand six times, with the TNT explosive weight increasing from 40g to 290g. A good agreement is also foundbetween the finite element results and empirical formulas proposed by Henrych and Sadovsky. However,inconsistent blasting responses are obtained with empirical formulas depending on the scaled distance.