Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey

ÖZEN, Necati; DEREBEY, Murat; YURUKER, Saim Savaş; KARABICAK, İlhan; KARABULUT, Kağan

doi:10.30714/j-ebr.2021165780

Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey

Murat DEREBEY, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Samsun, Türkiye)

Kağan KARABULUT, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Samsun, Türkiye)

Saim Savaş YURUKER, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Samsun, Türkiye)

İlhan KARABICAK, (VM Medical Park Hastanesi, Genel Cerrahi Anabilim Dalı, Samsun, Türkiye)

Necati ÖZEN (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Samsun, Türkiye)

Experimental Biomedical Research

0 0

Yıl: 2021 Cilt: 4 Sayı: 1 Sayfa Aralığı: 38 - 46 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2021165780 İndeks Tarihi: 05-06-2021

Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey

Öz:

Aim: To evaluate the risk factors in patients with pancreatic adenocarcinoma in Turkey's Black Sea region and to determine groups at high risk for pancreatic cancer. Methods: 106 newly diagnosed pancreatic adenocarcinoma patients living in Black Sea region of Turkey who applied to our clinic between January 2015 and December 2016 were included in this study. In the same period a control group was formed with 92 patients of similar age. Both groups were asked to fill out a form that questioned the pancreatic cancer risk factors. Data were analyzed. Results: Pancreatic cancer risk was 3.5 times higher in people over 65 years of age. Patients with deficient level of serum vitamin D level (<20 ng/ml) had 10.2 times more risk of pancreatic cancer than patients with normal level of Vitamin D (≥30 ng/ml). While newly diagnosed type 2 diabetics had 19.5 times higher risk of pancreatic cancer, long term type 2 diabetics had 1.2 times higher risk than normal individuals. Those with pancreatic cancer in family had 4.3 times higher risk than those who did not. It was observed that people with rhesus (Rh) antigen negative blood group has 70% less risk of pancreatic cancer. Conclusion: Determination of pancreatic cancer risk factors, organization of imaging and screening programs for high-risk people can provide early diagnosis of the disease and prolong survival.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

[1]Huxley R, Moghaddam A, Berrington de Gonzalez A, et al. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer. 2005;92(11):2076-83.
[2]Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34.
[3]Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87-100.
[4]Kimura Y, Hirata K, Mukaiya M, et al. Hand-assisted laparoscopic pyloruspreserving pancreaticoduodenectomy for pancreas head disease. Am J Surg. 2005;189(6):734-37.
[5]Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22(44):9694-5.
[6]Lippi G, Mattiuzz C. The global burden of pancreatic cancer. Arch Med Sci. 2020;16(4):820-24.
[7]Hidalgo M, Cascinu S, Kleeff J, et al. Addressing the challanges of pancreatic cancer: future directions for improving outcomes. Pancreatology. 2015;15(1):8-18.
[8]Ferlay J, Soerjomataram I, Ervik M, et al. Cancer incidence and mortality worldwide. International Agency for Research on Cancer, 2013; http://globocan.iarc.fr 5.
[9]American Cancer Society. Cancer facts and figures 2013. Atlanta, Ga: American Cancer Society, 2013.
[10]Stolzenberg-Solomon RZ, Jacobs EJ, et al. Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010;172(1):81-93.
[11]Kasiappan R, Sun Y, Lungchukiet P, et al. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer Res. 2014;74(21):6194-204.
[12]Iodice S, Gandini S, Maisonneuve P, et al. Langenbecks Arch Surg. 2008;393(4):535- 45.
[13]Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625-38.
[14]Pannala R, Leirness JB, Bamlet WR, et al. Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology. 2008;134(4):981-87.
[15]Benzel J, Fendrich V. Familial Pancreatic Cancer. Oncol Res Treat. 2018;41(10):611- 18.
[16]Michaud DS, Vrieling A, Jiao L, et al. Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. Cancer Causes Control. 2010;21(8):1213-5.
[17]Farrow DC, Davis S. Risk of pancreatic cancer in relation to medical history and the use tobacco, alcohol and coffee. Int J Cancer. 1990;45(5):816-20.
[18]Kudo Y, Kamisawa T, Anjiki H, et al. Incidence of and risk factors for developing pancreatic cancer in patients with chronic pancreatitis. Hepatogastroenterology. 2011;58(106):609-11.
[19]Lowenfels AB, Maisonneuve P, Whitcomb DC. Risk factors for cancer in hereditary pancreatitis. International Hereditary Pancreatitis Study Group. Med Clin North AM. 2000;84(3):565-73.
[20]Bulajic M, Maisonneuve P, Schneider- Brachert W, et al. Helicobacter pylori and the risk of bening and malignant biliary tract disease. Cancer. 2002;95(9):1946-3.
[21]World Cancer Research Fund American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global perspective. Washington (DC):AICR;2007.
[22]Bao Y, Michaud DS, Spiegelman D, et al. Folate Intake and Risk of Pancreatic Cancer: Pooled Analysis of Prospective Cohort Studies. J Natl Cancer Inst. 2011;103(24):1840-50.
[23] Annese V, Minervini M, Gabbrielli A, et al. ABO blood groups and cancer of the pancreas. Int J Pancreatol. 1990;6(2):81-88.
[24]Gandini S, Lowenfels AB, Jaffee EM, et al. Allergies and the risk of pancreatic cancer: a meta-analysis with review of epidemiology and biological mechanisms. Cancer Epidemiol Biomarkers Prev. 2005;14(8):1908-6.
[25]Gong Y, Zhou Q, Zhou Y, et al. Gastrectomy and risk of pancreatic cancer: systematic review and meta-analysis of observational studies. Cancer Causes Control. 2012;23(8):1279-8.
[26]Bosetti C, Lucenteforte E, Bracci PM, et al. Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2013;24(11):2903-10.

APA	DEREBEY M, KARABULUT K, YURUKER S, KARABICAK İ, ÖZEN N (2021). Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. , 38 - 46. 10.30714/j-ebr.2021165780
Chicago	DEREBEY Murat,KARABULUT Kağan,YURUKER Saim Savaş,KARABICAK İlhan,ÖZEN Necati Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. (2021): 38 - 46. 10.30714/j-ebr.2021165780
MLA	DEREBEY Murat,KARABULUT Kağan,YURUKER Saim Savaş,KARABICAK İlhan,ÖZEN Necati Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. , 2021, ss.38 - 46. 10.30714/j-ebr.2021165780
AMA	DEREBEY M,KARABULUT K,YURUKER S,KARABICAK İ,ÖZEN N Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. . 2021; 38 - 46. 10.30714/j-ebr.2021165780
Vancouver	DEREBEY M,KARABULUT K,YURUKER S,KARABICAK İ,ÖZEN N Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. . 2021; 38 - 46. 10.30714/j-ebr.2021165780
IEEE	DEREBEY M,KARABULUT K,YURUKER S,KARABICAK İ,ÖZEN N "Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey." , ss.38 - 46, 2021. 10.30714/j-ebr.2021165780
ISNAD	DEREBEY, Murat vd. "Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey". (2021), 38-46. https://doi.org/10.30714/j-ebr.2021165780

APA	DEREBEY M, KARABULUT K, YURUKER S, KARABICAK İ, ÖZEN N (2021). Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. Experimental Biomedical Research, 4(1), 38 - 46. 10.30714/j-ebr.2021165780
Chicago	DEREBEY Murat,KARABULUT Kağan,YURUKER Saim Savaş,KARABICAK İlhan,ÖZEN Necati Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. Experimental Biomedical Research 4, no.1 (2021): 38 - 46. 10.30714/j-ebr.2021165780
MLA	DEREBEY Murat,KARABULUT Kağan,YURUKER Saim Savaş,KARABICAK İlhan,ÖZEN Necati Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. Experimental Biomedical Research, vol.4, no.1, 2021, ss.38 - 46. 10.30714/j-ebr.2021165780
AMA	DEREBEY M,KARABULUT K,YURUKER S,KARABICAK İ,ÖZEN N Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. Experimental Biomedical Research. 2021; 4(1): 38 - 46. 10.30714/j-ebr.2021165780
Vancouver	DEREBEY M,KARABULUT K,YURUKER S,KARABICAK İ,ÖZEN N Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey. Experimental Biomedical Research. 2021; 4(1): 38 - 46. 10.30714/j-ebr.2021165780
IEEE	DEREBEY M,KARABULUT K,YURUKER S,KARABICAK İ,ÖZEN N "Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey." Experimental Biomedical Research, 4, ss.38 - 46, 2021. 10.30714/j-ebr.2021165780
ISNAD	DEREBEY, Murat vd. "Evaluation of risk factors associated with pancreatic adenocarcinoma in Black Sea region, Turkey". Experimental Biomedical Research 4/1 (2021), 38-46. https://doi.org/10.30714/j-ebr.2021165780