Objectives: This study aims to examine the diagnostic values of physical examination, laboratory and imagingmethods of pediatric patients, who were hospitalized, followed up and operated in the pediatric surgery clinicof our hospital with the diagnosis of acute appendicitis, to investigate a simple and useful scoring system thatcan be formed from those with the highest diagnostic value, and to compare scoring systems concerning theireffectiveness in diagnosing appendicitis and reducing negative appendectomy rates.Methods: The study group consisted of patients hospitalized and treated at the pediatric surgery clinic with apreliminary diagnosis of acute appendicitis between January 2016 and January 2019. The cases were dividedinto two different groups as appendicitis group (AG) and non-appendicitis group (NAG). Alvarado Appendicitis Score (AAS), Pediatric Appendicitis Score (PAS) and Tzanakis Appendicitis Score (TAS) of the patients werecalculated retrospectively in both groups.Results: The difference between the PAS, AAS and TAS of AG and NAG was statistically significant (p=0.042,p=0.021 and p=0.021, respectively). The rate of neutrophil-to-lymphocyte ratio of >3.5 in 53 (77.9%) of the AGgroup and 33 (63.4%) of NAG was higher than 3.5 (p=0.030).Conclusion: This study has shown that appendicitis scoring methods are as effective as imaging techniques inthe diagnosis of appendicitis, which is the most common cause of surgical abdominal pain in children admitting to emergency care units due to abdominal pain, as well as in reducing the negative appendectomy rates.