D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis
Yıl: 2020 Cilt: 68 Sayı: 4 Sayfa Aralığı: 353 - 360 Metin Dili: İngilizce DOI: 10.5578/tt.70351 İndeks Tarihi: 06-06-2021
D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis
Öz: Introduction: Coronavirus disease 2019 (COVID-19) is a fatal and pandemic disease discovered in December 2019 in Wuhan, with lots of asymptomatic cases and a long incubation period. The researchers suggested that high d-dimer levels could predict disease severity, lung complications, and throm-boembolic events before they occur. Materials and Methods: We searched in PubMed, Scopus, and Web of Science using the keywords “D-dimer” and “coronavirus” or “D-dimer” and “COVID-19.” We used Standardized Mean Differences (SMD) to build forest plots of continuous data and assess differences in serum D-dimer concentra-tions between severe and non-severe patients with COVID-19 disease. We evaluated p-value < 0.05 as statistically significant and preferred 95% confi-dence intervals (CIs).Results: The pooled results of all studies revealed that the D-dimer concentra-tions were significantly higher in patients with more severe COVID-19 (SMD: 2.32 μg/mL; 95% CI, 0.72 3.92 μg/mL, p< 0.001). We evaluated severe pati-ents with total D-dimer levels. D-dimer concentrations were significantly hig-her in severe patients against total COVID-19 patients (SMD: 2.01 μg/mL; 95% CI, 0.25 to 3.77 μg/mL, p= 0.08).Conclusion: We do not know the D-dimer increment mechanism in severe patients yet, but we think that these findings will be useful in the early diag-nosis of severe disease and the first treatment.
Anahtar Kelime: D-dimer seviyeleri ve COVID-19 şiddeti: Sistematik Derleme ve Metaanaliz
Öz: Giriş: Koronavirüs hastalığı 2019 (COVID-19), Aralık 2019’da Wuhan’da keşfedilen, çok sayıda asemptomatik vaka ve uzun bir kuluç-ka dönemi ile ölümcül ve pandemik bir hastalıktır. Araştırmacılar, yüksek D-dimer seviyelerinin hastalık şiddetini, akciğer komplikas-yonlarını ve tromboembolik olayları ortaya çıkmadan önce tahmin edebileceğini öne sürdü.Materyal ve Metod: PubMed, Scopus ve Web of Science’ta “D-dimer” ve “koronavirüs” veya “D-dimer” ve “COVID-19” anahtar kelimelerini kullanarak arama yaptık. Sürekli verilerin forest plot analizi ve COVID-19 enfeksiyonlu, şiddetli ve şiddetli olmayan has-talar arasındaki serum D-dimer konsantrasyonlarındaki farklılıkları değerlendirmek için Standart Ortalama Farklılıkları (SMD) kullan-dık. P değerini <0.05 istatistiksel olarak anlamlı olarak değerlendirdik ve %95 güven aralıklarını (CI) tercih ettik.Bulgular: Tüm çalışmaların havuzlanmış sonuçları, daha şiddetli COVID-19 hastalarında D-dimer konsantrasyonlarının önemli ölçüde daha yüksek olduğunu ortaya çıkarmıştır (SMD: 2.32 μg/mL;%95 CI, 0.72 3.92 μg/mL, p< 0.001). D-dimer konsantrasyonları, şid-detli hastalarda tüm COVID-19 hastalarına göre anlamlı olarak daha yüksekti (SMD: 2.01 μg/mL; %95 CI, 0.25 ila 3.77 μg/mL, p= 0.08).Sonuç: Şiddetli hastalarda D-dimer artış mekanizmasını henüz bilmiyoruz ancak bu bulguların ağır hastalığın erken teşhisinde ve ilk tedavide faydalı olacağını düşünüyoruz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | DÜZ M, BALCI A, MENEKŞE E (2020). D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. , 353 - 360. 10.5578/tt.70351 |
| Chicago | DÜZ Muhammed Emin,BALCI AYDIN,MENEKŞE Elif D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. (2020): 353 - 360. 10.5578/tt.70351 |
| MLA | DÜZ Muhammed Emin,BALCI AYDIN,MENEKŞE Elif D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. , 2020, ss.353 - 360. 10.5578/tt.70351 |
| AMA | DÜZ M,BALCI A,MENEKŞE E D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. . 2020; 353 - 360. 10.5578/tt.70351 |
| Vancouver | DÜZ M,BALCI A,MENEKŞE E D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. . 2020; 353 - 360. 10.5578/tt.70351 |
| IEEE | DÜZ M,BALCI A,MENEKŞE E "D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis." , ss.353 - 360, 2020. 10.5578/tt.70351 |
| ISNAD | DÜZ, Muhammed Emin vd. "D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis". (2020), 353-360. https://doi.org/10.5578/tt.70351 |
| APA | DÜZ M, BALCI A, MENEKŞE E (2020). D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. Tüberküloz ve Toraks, 68(4), 353 - 360. 10.5578/tt.70351 |
| Chicago | DÜZ Muhammed Emin,BALCI AYDIN,MENEKŞE Elif D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. Tüberküloz ve Toraks 68, no.4 (2020): 353 - 360. 10.5578/tt.70351 |
| MLA | DÜZ Muhammed Emin,BALCI AYDIN,MENEKŞE Elif D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. Tüberküloz ve Toraks, vol.68, no.4, 2020, ss.353 - 360. 10.5578/tt.70351 |
| AMA | DÜZ M,BALCI A,MENEKŞE E D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. Tüberküloz ve Toraks. 2020; 68(4): 353 - 360. 10.5578/tt.70351 |
| Vancouver | DÜZ M,BALCI A,MENEKŞE E D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. Tüberküloz ve Toraks. 2020; 68(4): 353 - 360. 10.5578/tt.70351 |
| IEEE | DÜZ M,BALCI A,MENEKŞE E "D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis." Tüberküloz ve Toraks, 68, ss.353 - 360, 2020. 10.5578/tt.70351 |
| ISNAD | DÜZ, Muhammed Emin vd. "D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis". Tüberküloz ve Toraks 68/4 (2020), 353-360. https://doi.org/10.5578/tt.70351 |
