TY  - JOUR
TI  - Investigation of the Cytotoxic Effect of Ethyl Pyruvate on Various Cancer Cell Lines
AB  - Ethyl pyruvate (EP) is a simple aliphatic ester derived from pyruvicacid which is an endogenous metabolite. Although various studieshave investigated the antioxidant and anti-inflammatory propertiesof EP, there has been only limited research into the cytotoxic effect ofEP on cancer cells. The aim of this study was to determine thecytotoxic effects of EP on cells representing common cancer types. EPwas purchased commercially and intermediate stock solutions wereprepared with phosphate buffer saline. The cytotoxic effect of EP onhuman melanoma (VMM917), cervix (HeLa), breast (MCF-7), lung(A549), liver (HepG2), colon (WiDr) cancer and normal fibroblast (BJ)cells was determined using the MTT assay. Cisplatin was used as apositive control in cytotoxicity experiments. The results showed thatEP exhibits selective cytotoxic effect on VMM917 (10.1-fold) and HeLa(3.04-fold) cells compared to BJ cells. This study shows for the firsttime that EP has a highly selective cytotoxic effect, especially onmelanoma and cervix cancer cells. The mechanism of this effect needsto be elucidated by more extensive studies.
AU  - TURAN, IBRAHIM
AU  - SEYAZ, MEHTAP
AU  - Demir, Selim
DO  - 10.18016/ksutarimdoga.vi.707661
PY  - 2021
JO  - Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
VL  - 24
IS  - 1
SN  - 2619-9149
SP  - 49
EP  - 56
DB  - TRDizin
UR  - http://search/yayin/detay/418683
ER  -