Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi

ÖNER, Ayse; Sinim Kahraman, Neslihan

Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi

Ayşe ÖNER, (Acıbadem Kayseri Hastanesi, Göz Hastalıkları Kliniği, Kayseri, Türkiye)

Neslihan Sinim KAHRAMAN (Acıbadem Kayseri Hastanesi, Göz Hastalıkları Kliniği, Kayseri, Türkiye)

Güncel Retina Dergisi

5 0

Yıl: 2021 Cilt: 5 Sayı: 2 Sayfa Aralığı: 131 - 139 Metin Dili: Türkçe İndeks Tarihi: 07-06-2021

Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi

Öz:

Retinitis pigmentosa, herediter retina distrofileri içinde en sık görülenidir. Kliniği ve genetik geçişi oldukça çeşitlilik gösterir. Hastalığın semptomları sırayla gece körlüğü, tünel görme ve takiben tamamen körlük oluşumu şeklindedir. Neden olan genlerin gelişimsel ya da fonksiyonel işlevlerde görevleri vardır ve fenotipten sorumlu olan 120’den fazla gen mutasyonu bilinmektedir. Ayrıca aynı ailede, aynı gen içinde olan mutasyonların bile farklı fenotiplere yol açabildiği görülmekte; bu da genetik nedenlerin karmaşıklığını ortaya koymaktadır. Son yıllarda hastalığın patogenezinin anlaşılmasına yönelik gelişmeler, tedavide kök hücre ve gen tedavisi gibi etkin uygulamaların yapılmasını sağlamıştır. Bu derlemede kök hücre ve gen tedavilerinin klinik gelişimleri özetlenmiştir.

Anahtar Kelime:

Konular: Transplantasyon

Retinal Transplantation, Stem Cell and Gene Therapy in Retinitis Pigmentosa

Öz:

Retinitis pigmentosa is the most common hereditary retinal dystrophy which has marked clinical and genetic heterogeneity. Common presentations among this disorder include night blindness, tunnel vision, and subsequent progression to complete blindness respectively. The known causative disease genes have a variety of developmental and functional roles, with mutations in more than 120 genes shown to be responsible for the phenotypes. In addition, mutations within the same gene have been shown to cause different disease phenotypes, even within the same family, highlighting further levels of complexity.In recent years significant advancements have been made in the understanding of the pathogenesis of the disease and stem cell and gene replacement treatments have been proposed as potentially efficacious therapies. This review summarizes the clinical development of retinal stem cell and gene therapy.

Anahtar Kelime:

Konular: Transplantasyon

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Bibliyografik

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APA	ÖNER A, Sinim Kahraman N (2021). Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. , 131 - 139.
Chicago	ÖNER Ayse,Sinim Kahraman Neslihan Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. (2021): 131 - 139.
MLA	ÖNER Ayse,Sinim Kahraman Neslihan Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. , 2021, ss.131 - 139.
AMA	ÖNER A,Sinim Kahraman N Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. . 2021; 131 - 139.
Vancouver	ÖNER A,Sinim Kahraman N Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. . 2021; 131 - 139.
IEEE	ÖNER A,Sinim Kahraman N "Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi." , ss.131 - 139, 2021.
ISNAD	ÖNER, Ayse - Sinim Kahraman, Neslihan. "Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi". (2021), 131-139.

APA	ÖNER A, Sinim Kahraman N (2021). Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. Güncel Retina Dergisi, 5(2), 131 - 139.
Chicago	ÖNER Ayse,Sinim Kahraman Neslihan Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. Güncel Retina Dergisi 5, no.2 (2021): 131 - 139.
MLA	ÖNER Ayse,Sinim Kahraman Neslihan Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. Güncel Retina Dergisi, vol.5, no.2, 2021, ss.131 - 139.
AMA	ÖNER A,Sinim Kahraman N Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. Güncel Retina Dergisi. 2021; 5(2): 131 - 139.
Vancouver	ÖNER A,Sinim Kahraman N Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi. Güncel Retina Dergisi. 2021; 5(2): 131 - 139.
IEEE	ÖNER A,Sinim Kahraman N "Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi." Güncel Retina Dergisi, 5, ss.131 - 139, 2021.
ISNAD	ÖNER, Ayse - Sinim Kahraman, Neslihan. "Retinitis Pigmentosada Retina Transplantasyonu, Kök Hücre ve Gen Tedavisi". Güncel Retina Dergisi 5/2 (2021), 131-139.