TY  - JOUR
TI  - Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells
AB  - The aim of this study was to investigate the antioxidant properties ofthe root extract of Onosma armeniacum and its cytotoxic effect againsthuman liver (HepG2), lung (A549) and colon (WiDr) cancer cell linescompared with a normal fibroblast cell line. Antioxidant properties ofthe extract was determined using the colorimetric methods. Thecytotoxic effect of the extract were investigated using MTT assay. Thetotal phenolic content and reducing power values of extract were26.1±0.4 mg gallic acid equivalent and 52.6±1.1 mg trolox equivalentper g sample, respectively. The extract exhibited selective cytotoxiceffect in all studied cancer cell lines, especially HepG2 (3.6-fold). Theresults of this study reveal that O. armeniacum, which has been foundto have acceptable antioxidant and cytotoxic effects, should beexamined with more comprehensive studies.
AU  - TURAN, IBRAHIM
AU  - Özgen, Ufuk
AU  - SEYAZ, MEHTAP
AU  - Demir, Selim
DO  - 10.18016/ksutarimdoga.vi.729814
PY  - 2021
JO  - Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
VL  - 24
IS  - 2
SN  - 2619-9149
SP  - 252
EP  - 259
DB  - TRDizin
UR  - http://search/yayin/detay/419221
ER  -