Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors

Tuna DEMİRCİ, (Düzce Üniversitesi, Düzce, Türkiye)
Oğuzhan ÖZDEMİR, (Batman Üniversitesi, Batman, Türkiye)
Mustafa Oğuzhan KAYA, (Kocaeli Üniversitesi, Kocaeli, Türkiye)
Mustafa ARSLAN (Sakarya Üniversitesi, Sakarya, Türkiye)
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
3 0
Yıl: 2021 Cilt: 25 Sayı: 1 Sayfa Aralığı: 200 - 211 Metin Dili: İngilizce DOI: 10.16984/saufenbilder.688414 İndeks Tarihi: 10-06-2021

Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors

Öz:
Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesizedand their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives inbasic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were synthesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysisof the compounds. The half maximal inhibitory concentration (IC50) values of the compoundswere determined to be between 27.03 and 104.39 μM for hCA II and 19.85-76.64 μM for Ki.
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APA Demirci T, OZDEMIR O, KAYA M, ARSLAN M (2021). Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. , 200 - 211. 10.16984/saufenbilder.688414
Chicago Demirci Tuna,OZDEMIR OGUZHAN,KAYA Mustafa Oğuzhan,ARSLAN Mustafa Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. (2021): 200 - 211. 10.16984/saufenbilder.688414
MLA Demirci Tuna,OZDEMIR OGUZHAN,KAYA Mustafa Oğuzhan,ARSLAN Mustafa Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. , 2021, ss.200 - 211. 10.16984/saufenbilder.688414
AMA Demirci T,OZDEMIR O,KAYA M,ARSLAN M Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. . 2021; 200 - 211. 10.16984/saufenbilder.688414
Vancouver Demirci T,OZDEMIR O,KAYA M,ARSLAN M Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. . 2021; 200 - 211. 10.16984/saufenbilder.688414
IEEE Demirci T,OZDEMIR O,KAYA M,ARSLAN M "Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors." , ss.200 - 211, 2021. 10.16984/saufenbilder.688414
ISNAD Demirci, Tuna vd. "Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors". (2021), 200-211. https://doi.org/10.16984/saufenbilder.688414
APA Demirci T, OZDEMIR O, KAYA M, ARSLAN M (2021). Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 25(1), 200 - 211. 10.16984/saufenbilder.688414
Chicago Demirci Tuna,OZDEMIR OGUZHAN,KAYA Mustafa Oğuzhan,ARSLAN Mustafa Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi 25, no.1 (2021): 200 - 211. 10.16984/saufenbilder.688414
MLA Demirci Tuna,OZDEMIR OGUZHAN,KAYA Mustafa Oğuzhan,ARSLAN Mustafa Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol.25, no.1, 2021, ss.200 - 211. 10.16984/saufenbilder.688414
AMA Demirci T,OZDEMIR O,KAYA M,ARSLAN M Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2021; 25(1): 200 - 211. 10.16984/saufenbilder.688414
Vancouver Demirci T,OZDEMIR O,KAYA M,ARSLAN M Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2021; 25(1): 200 - 211. 10.16984/saufenbilder.688414
IEEE Demirci T,OZDEMIR O,KAYA M,ARSLAN M "Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors." Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 25, ss.200 - 211, 2021. 10.16984/saufenbilder.688414
ISNAD Demirci, Tuna vd. "Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors". Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi 25/1 (2021), 200-211. https://doi.org/10.16984/saufenbilder.688414
Sayfa Oluşturulma Tarihi
17-04-2024 20:2

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