Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats
Yıl: 2021 Cilt: 22 Sayı: 1 Sayfa Aralığı: 53 - 56 Metin Dili: İngilizce DOI: 10.4274/meandros.galenos.2021.65002 İndeks Tarihi: 11-06-2021
Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats
Öz: Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model.Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administered high-dose DEX (300 mg/kg/day) as a safety group. Diabetes was induced by intraperitoneal injection of a single dose of STZ (50 mg/kg) in groups 3 and 4. In group 4, DEX was administered as well. All groups were followed up for 6 weeks. Histopathological analyses were performed on renal tissue using periodic acid-Schiff and Hematoxylin Eosin stains.Results: Microscopic evaluation of the kidney revealed that the rats demonstrated kidney damage 6 weeks after STZ administration. However, high-dose and long term DEX administration alone did not damage renal tissue; moreover, kidney damage was prevented if DEX was administered in the early phase of diabetes.Conclusion: DEX could be a safe and cost-effective vitamin for the prevention of diabetes complications.
Anahtar Kelime: Sıçanlarda B5 Vitamininin (Dekspantenol) Nefropatiye Etkisi
Öz: Amaç: Çalışmamızda streptozotosin (STZ) diyabet hayvan modelinde B5[dexpanthenol (DEX)] vitamini ile tedavinin böbrek üzerindeki etkilerinideğerlendirdik. Gereç ve Yöntemler: Yirmi dört wistar sıçanı dört gruba eşit ve randomize olarakdağıtıldı. Grup 1 kontrol grubu; grup 2 güvenlik grubu olarak yüksek doz DEX (300mg/kg/gün) verildi. Diyabet, grup 3 ve 4’te tek bir intraperitoneal doz STZ (50 mg/ kg) enjeksiyonu ile oluşturuldu. Grup 4 DEX ile tedavi edildi. Tüm gruplar 6 haftatakip edildi. Periyodik asit Schiff ve Hematoksilen-Eosin kullanılarak böbrek dokusuüzerinde histopatolojik incelemeler yapıldı. Bulgular: Böbreğin mikroskobik değerlendirmesinde, sıçanlarda STZmüdahalesinden 6 hafta sonra böbrek hasarı geliştiği görüldü. Tek başına yüksekve uzun süreli DEX uygulaması böbrek dokusu için zararlı değildi. Ayrıca diyabetinerken evresinde DEX verilmesi böbrek hasarını önledi. Sonuç: Diyabet komplikasyonlarını önlemek için DEX güvenli ve uygun maliyetlibir vitamin olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Ceri N, GÜLLE K, ARASLI M, Akpolat M, Demirci B (2021). Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. , 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| Chicago | Ceri Nazli Gulriz,GÜLLE KANAT,ARASLI MEHMET,Akpolat Meryem,Demirci Buket Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. (2021): 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| MLA | Ceri Nazli Gulriz,GÜLLE KANAT,ARASLI MEHMET,Akpolat Meryem,Demirci Buket Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. , 2021, ss.53 - 56. 10.4274/meandros.galenos.2021.65002 |
| AMA | Ceri N,GÜLLE K,ARASLI M,Akpolat M,Demirci B Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. . 2021; 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| Vancouver | Ceri N,GÜLLE K,ARASLI M,Akpolat M,Demirci B Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. . 2021; 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| IEEE | Ceri N,GÜLLE K,ARASLI M,Akpolat M,Demirci B "Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats." , ss.53 - 56, 2021. 10.4274/meandros.galenos.2021.65002 |
| ISNAD | Ceri, Nazli Gulriz vd. "Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats". (2021), 53-56. https://doi.org/10.4274/meandros.galenos.2021.65002 |
| APA | Ceri N, GÜLLE K, ARASLI M, Akpolat M, Demirci B (2021). Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. Meandros Medical And Dental Journal, 22(1), 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| Chicago | Ceri Nazli Gulriz,GÜLLE KANAT,ARASLI MEHMET,Akpolat Meryem,Demirci Buket Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. Meandros Medical And Dental Journal 22, no.1 (2021): 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| MLA | Ceri Nazli Gulriz,GÜLLE KANAT,ARASLI MEHMET,Akpolat Meryem,Demirci Buket Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. Meandros Medical And Dental Journal, vol.22, no.1, 2021, ss.53 - 56. 10.4274/meandros.galenos.2021.65002 |
| AMA | Ceri N,GÜLLE K,ARASLI M,Akpolat M,Demirci B Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. Meandros Medical And Dental Journal. 2021; 22(1): 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| Vancouver | Ceri N,GÜLLE K,ARASLI M,Akpolat M,Demirci B Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats. Meandros Medical And Dental Journal. 2021; 22(1): 53 - 56. 10.4274/meandros.galenos.2021.65002 |
| IEEE | Ceri N,GÜLLE K,ARASLI M,Akpolat M,Demirci B "Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats." Meandros Medical And Dental Journal, 22, ss.53 - 56, 2021. 10.4274/meandros.galenos.2021.65002 |
| ISNAD | Ceri, Nazli Gulriz vd. "Protective Effect of Vitamin B5(Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats". Meandros Medical And Dental Journal 22/1 (2021), 53-56. https://doi.org/10.4274/meandros.galenos.2021.65002 |
