One hundredforty six children living in the city center of Malatya and diagnosed as enu-resis according to DSM-IV were to examine the demographic characteristics and familial transmission of the subjects. Of these ehilden 60.3% were male, 39.7 were female, and the mean of age was 8.78 years. None of the chidren had been using medication for the last year. 78.l%of subjects were primary 21.9% were secondary enuretics. 64.5% of the secondary enuretics described a spontaneous onset. There was a history of enuresis in most of their primary and secondry relatives, respectively 58.9% and 54.1%. The frequ¬ency of dail wetter was 51.4% - 24.7% of subjects were diurnal in character. Maternal wetting ratio were significantly higher among the girls. There was no obvious difference between primary and secondry enuretics in respects to wetting of siblings and parents. The frequency of wetting and the frequency of physical and psychiatric disorder comor-bidity were increasing proportionally. This disorder which is seen more in male is accep¬ted as an elimination disorder which is blological-devolepmental dysfunction based on familial and genetic heritance. To understand the disease and to create more effective therapy methods, biological studies must be based on more.