Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats
Yıl: 2020 Cilt: 7 Sayı: 6 Sayfa Aralığı: 541 - 550 Metin Dili: İngilizce DOI: 10.14744/nci.2020.54926 İndeks Tarihi: 13-06-2021
Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats
Öz: OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.METHODS: Wistar-albino rats were used in this study. At doses of 20–500 mg/kg, paracetamol was administered intraperitoneally once a day for one and three days. The brain and liver were used for immunohistochemical evaluation using COX-3, prostaglandin E2 (PGE2) and caspase 3 antibodies and for total antioxidant (TAS), total oxidant (TOS) and oxidative stress index (OSI) measurements. Results were evaluated using the Kruskal Wallis test (SPSS ver.24).RESULTS: The liver COX-3 levels were significantly lower in both groups with higher doses (p<0.05). In the brain, there was no statistically significant difference in COX-3 levels between the groups. There was no statistically significant difference in PGE2 levels in the liver and brain between the groups (p>0.05). The caspase 3 level in the liver was statistically significantly higher in the low dose group compared to the other groups (p<0.05). In both liver and brain, OSI values were significantly higher in the 3-day high-dose group compared to others (p<0.05). There was no statistically significant difference between the groups in ALT and AST values (p>0.05).CONCLUSION: The results of our study show that paracetamol inhibits the COX-3 enzyme in the liver but has no effect in the brain, and COX-3 does not have an effect on PGE2. Paracetamol causes apoptosis in the liver only in low doses; higher doses may cause toxicity by increasing oxidative stress, especially in the brain.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | öksüz e, yaşar s, Erten R, ARIHAN O, Oto G (2020). Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. , 541 - 550. 10.14744/nci.2020.54926 |
| Chicago | öksüz ersoy,yaşar semih,Erten Remzi,ARIHAN Okan,Oto Gökhan Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. (2020): 541 - 550. 10.14744/nci.2020.54926 |
| MLA | öksüz ersoy,yaşar semih,Erten Remzi,ARIHAN Okan,Oto Gökhan Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. , 2020, ss.541 - 550. 10.14744/nci.2020.54926 |
| AMA | öksüz e,yaşar s,Erten R,ARIHAN O,Oto G Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. . 2020; 541 - 550. 10.14744/nci.2020.54926 |
| Vancouver | öksüz e,yaşar s,Erten R,ARIHAN O,Oto G Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. . 2020; 541 - 550. 10.14744/nci.2020.54926 |
| IEEE | öksüz e,yaşar s,Erten R,ARIHAN O,Oto G "Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats." , ss.541 - 550, 2020. 10.14744/nci.2020.54926 |
| ISNAD | öksüz, ersoy vd. "Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats". (2020), 541-550. https://doi.org/10.14744/nci.2020.54926 |
| APA | öksüz e, yaşar s, Erten R, ARIHAN O, Oto G (2020). Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. İstanbul Kuzey Klinikleri, 7(6), 541 - 550. 10.14744/nci.2020.54926 |
| Chicago | öksüz ersoy,yaşar semih,Erten Remzi,ARIHAN Okan,Oto Gökhan Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. İstanbul Kuzey Klinikleri 7, no.6 (2020): 541 - 550. 10.14744/nci.2020.54926 |
| MLA | öksüz ersoy,yaşar semih,Erten Remzi,ARIHAN Okan,Oto Gökhan Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. İstanbul Kuzey Klinikleri, vol.7, no.6, 2020, ss.541 - 550. 10.14744/nci.2020.54926 |
| AMA | öksüz e,yaşar s,Erten R,ARIHAN O,Oto G Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. İstanbul Kuzey Klinikleri. 2020; 7(6): 541 - 550. 10.14744/nci.2020.54926 |
| Vancouver | öksüz e,yaşar s,Erten R,ARIHAN O,Oto G Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats. İstanbul Kuzey Klinikleri. 2020; 7(6): 541 - 550. 10.14744/nci.2020.54926 |
| IEEE | öksüz e,yaşar s,Erten R,ARIHAN O,Oto G "Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats." İstanbul Kuzey Klinikleri, 7, ss.541 - 550, 2020. 10.14744/nci.2020.54926 |
| ISNAD | öksüz, ersoy vd. "Comparison of effects of high and low doseparacetamol treatment and toxicity on brain and liver in rats". İstanbul Kuzey Klinikleri 7/6 (2020), 541-550. https://doi.org/10.14744/nci.2020.54926 |
