White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats

Hazineci, Hazal; YANARDAG, REFIYE; Ustundag, Unsal Veli; İpekçi, Hazal; Tunali-Akbay, Tugba; Emekli-Alturfan, Ebru; Turkyilmaz, Ismet Burcu; Yarat, Aysen; Alev-Tuzuner, Burcin

doi:10.26650/experimed.2020.0004

White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats

Hazal HAZİNECİ, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Temel Tıp Bilimleri, Biyokimya, İstanbul, Türkiye)

İsmet Burcu TÜRKYILMAZ, (İstanbul Üniversitesi-Cerrahpaşa, Mühendislik Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Ünsal Veli ÜSTÜNDAĞ, (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Ebru EMEKLİ ALTURFAN, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Temel Tıp Bilimleri, Biyokimya, İstanbul, Türkiye)

Burçin ALEV, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Temel Tıp Bilimleri, Biyokimya, İstanbul, Türkiye)

Hazal İPEKÇİ, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Temel Tıp Bilimleri, Biyokimya, İstanbul, Türkiye)

Tuğba TUNALI AKBAY, (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Temel Tıp Bilimleri, Biyokimya, İstanbul, Türkiye)

Refiye YANARDAG, (İstanbul Üniversitesi-Cerrahpaşa, Mühendislik Fakültesi, Kimya Bölümü, İstanbul, Türkiye)

Ayşen YARAT (Marmara Üniversitesi, Diş Hekimliği Fakültesi, Temel Tıp Bilimleri, Biyokimya, İstanbul, Türkiye)

EXPERIMED

5 1

Yıl: 2020 Cilt: 10 Sayı: 1 Sayfa Aralığı: 1 - 6 Metin Dili: İngilizce DOI: 10.26650/experimed.2020.0004 İndeks Tarihi: 13-06-2021

White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats

Öz:

Objective: Amiodarone is used in the treatment of arrhythmia andhas been shown to cause side effects in various organs. White cabbage(Brassica oleracea L. var. capitata) is a widely consumed vegetable.The effects of exposure to amiodarone and white cabbageconsumption on heart tissue has not previously been investigated.We aimed to investigate the effects of white cabbage extract onamiodarone given to rats’ cardiac tissues.Material and Method: Rats were given white cabbage extract andamiodarone by gavage for seven days. Amiodarone was applied1 hour after administration of the white cabbage extract. On theeighth day, the hearts of the animals were taken and homogenized.The levels of lipid peroxidation (LPO), reduced glutathione(GSH), sialic acid (SA) and activities of glutathione-S-transferase(GST), catalase, superoxide dismutase (SOD) and tissue factor (TF)were determined.Results: The GSH level, CAT and SOD activities decreased, while theLPO and SA levels increased in the amiodarone treated group. TheWhite cabbage extract prevented any damage of the amiodaroneby decreasing the amount of LPO and SA and also strengthenedthe antioxidant defence system by increasing the amount of theGSH and SOD activities and the CAT and GST activities.Conclusion: It is suggested that the consumption of white cabbagecould be an alternative approach to the prevention of theadverse effects of amiodarone on heart tissue.

Anahtar Kelime:

Beyaz Lahana Ekstresi Amiodaronun Sıçanlarda Kalp Dokusu Üzerindeki Zararlı Etkilerini İyileştirir

Öz:

Amaç: Aritmi tedavisinde kullanılan amiodaronun çeşitli organlarda yan etkilere neden olduğu gösterilmiştir. Beyaz lahana (Brassica oleracea L. var. capitata) yaygın olarak tüketilen bir sebzedir. Amiodaron maruziyeti ve beyaz lahana tüketiminin kalp dokusu üzerindeki etkileri araştırılmamıştır. Beyaz lahana ekstraktının amiodaron uygulanan sıçanların kalp dokuları üzerindeki etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Sıçanlara yedi gün boyunca gavajla beyaz lahana ekstresi ve amiodaron verildi. Beyaz lahana ekstresinin uygulanmasından 1 saat sonra amiodaron uygulandı. Sekizinci günde, hayvanların kalpleri alındı ve homojenize edildi. Lipit peroksidasyon (LPO), indirgenmiş glutatyon (GSH), siyalik asit (SA) düzeyleri ile glutatyon-S-transferaz (GST), katalaz, süperoksit dismutaz (SOD) ve doku faktörü (TF) aktiviteleri belirlendi. Bulgular: Amiodaron verilen grupta GSH, CAT, SOD aktiviteleri azalırken LPO ve SA seviyeleri arttı. Beyaz lahana, LPO ve SA miktarını azaltarak amiodaron zararını önledi. Ayrıca GSH düzeyleri ile SOD, CAT ve GST aktivitelerini artırarak antioksidan savunma sistemini güçlendirdi. Sonuç: Beyaz lahana tüketiminin, amiodaronun kalp dokusunda olumsuz etkilerini önlemek için alternatif bir yaklaşım olabileceği ileri sürülebilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Hazineci H, Turkyilmaz I, Ustundag U, Emekli-Alturfan E, Alev-Tuzuner B, İpekçi H, Tunali-Akbay T, YANARDAG R, Yarat A (2020). White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. , 1 - 6. 10.26650/experimed.2020.0004
Chicago	Hazineci Hazal,Turkyilmaz Ismet Burcu,Ustundag Unsal Veli,Emekli-Alturfan Ebru,Alev-Tuzuner Burcin,İpekçi Hazal,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. (2020): 1 - 6. 10.26650/experimed.2020.0004
MLA	Hazineci Hazal,Turkyilmaz Ismet Burcu,Ustundag Unsal Veli,Emekli-Alturfan Ebru,Alev-Tuzuner Burcin,İpekçi Hazal,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. , 2020, ss.1 - 6. 10.26650/experimed.2020.0004
AMA	Hazineci H,Turkyilmaz I,Ustundag U,Emekli-Alturfan E,Alev-Tuzuner B,İpekçi H,Tunali-Akbay T,YANARDAG R,Yarat A White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. . 2020; 1 - 6. 10.26650/experimed.2020.0004
Vancouver	Hazineci H,Turkyilmaz I,Ustundag U,Emekli-Alturfan E,Alev-Tuzuner B,İpekçi H,Tunali-Akbay T,YANARDAG R,Yarat A White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. . 2020; 1 - 6. 10.26650/experimed.2020.0004
IEEE	Hazineci H,Turkyilmaz I,Ustundag U,Emekli-Alturfan E,Alev-Tuzuner B,İpekçi H,Tunali-Akbay T,YANARDAG R,Yarat A "White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats." , ss.1 - 6, 2020. 10.26650/experimed.2020.0004
ISNAD	Hazineci, Hazal vd. "White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats". (2020), 1-6. https://doi.org/10.26650/experimed.2020.0004

APA	Hazineci H, Turkyilmaz I, Ustundag U, Emekli-Alturfan E, Alev-Tuzuner B, İpekçi H, Tunali-Akbay T, YANARDAG R, Yarat A (2020). White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. EXPERIMED, 10(1), 1 - 6. 10.26650/experimed.2020.0004
Chicago	Hazineci Hazal,Turkyilmaz Ismet Burcu,Ustundag Unsal Veli,Emekli-Alturfan Ebru,Alev-Tuzuner Burcin,İpekçi Hazal,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. EXPERIMED 10, no.1 (2020): 1 - 6. 10.26650/experimed.2020.0004
MLA	Hazineci Hazal,Turkyilmaz Ismet Burcu,Ustundag Unsal Veli,Emekli-Alturfan Ebru,Alev-Tuzuner Burcin,İpekçi Hazal,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. EXPERIMED, vol.10, no.1, 2020, ss.1 - 6. 10.26650/experimed.2020.0004
AMA	Hazineci H,Turkyilmaz I,Ustundag U,Emekli-Alturfan E,Alev-Tuzuner B,İpekçi H,Tunali-Akbay T,YANARDAG R,Yarat A White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. EXPERIMED. 2020; 10(1): 1 - 6. 10.26650/experimed.2020.0004
Vancouver	Hazineci H,Turkyilmaz I,Ustundag U,Emekli-Alturfan E,Alev-Tuzuner B,İpekçi H,Tunali-Akbay T,YANARDAG R,Yarat A White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats. EXPERIMED. 2020; 10(1): 1 - 6. 10.26650/experimed.2020.0004
IEEE	Hazineci H,Turkyilmaz I,Ustundag U,Emekli-Alturfan E,Alev-Tuzuner B,İpekçi H,Tunali-Akbay T,YANARDAG R,Yarat A "White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats." EXPERIMED, 10, ss.1 - 6, 2020. 10.26650/experimed.2020.0004
ISNAD	Hazineci, Hazal vd. "White Cabbage Extract Reduces the Harmful Effects of Amiodarone on Heart Tissue in Rats". EXPERIMED 10/1 (2020), 1-6. https://doi.org/10.26650/experimed.2020.0004