TY  - JOUR
TI  - Impact of UCP2 -866G/A Variant on Smoking Risk
AB  - Objective: Mitochondria are multifunctional and dynamicorganelles found in cells. Nicotine is a natural alkaloid found inthe tobacco plant and has been well studied as a component ofcigarette smoke. It has also been reported to affect mitochondrialfunction both in vitro and in vivo. Uncoupling protein 2 (UCP2)reduces generation of ROS by mitochondria. Our purpose in thisstudy was to investigate whether the -866G/A variant of the UCP2gene is associated with smoking status.Methods: A total of 238 individuals consisting of 138 smokers and100 healthy controls were examined. The UCP2-866G/A variantwas genotyped by polymerase chain reaction-restriction fragmentlength polymorphism method.Results: The proportion of individuals carrying the three possiblegenotype was significantly different between the smoker and healthycontrol groups. The UCP2-866G/A variant GG genotype wasassociated significantly with an increased risk of smoking (p=0.001)while AA genotype was associated significantly with a decreased riskof smoking (p=0.001). The UCP2-866G/A variant G allele wasfound to be increased in the smoker group compared to the healthycontrols (p=0.001).Conclusion: Our data suggest that the UCP2-866 G/A variant GGgenotype and G allele might reflect the risk of smoking status in aTurkish population
AU  - PEHLİVAN, MUSTAFA
AU  - Sever, Ülgen
AU  - UYSAL, MEHMET ATILLA
AU  - pehlivan, sacide
AU  - Nursal, Ayse Feyda
DO  - 10.14235/bas.galenos.2020.4159
PY  - 2021
JO  - Bezmiâlem Science
VL  - 9
IS  - 2
SN  - 2148-2373
SP  - 185
EP  - 189
DB  - TRDizin
UR  - http://search/yayin/detay/422301
ER  -