Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi

Eser-Ozturk, Hilal

Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi

Hilal ESER ÖZTÜRK (Ondokuz Mayıs Üniversitesi, Göz Hastalıkları Anabilim Dalı, Samsun, Türkiye)

Güncel Retina Dergisi

262 0

Yıl: 2021 Cilt: 5 Sayı: 1 Sayfa Aralığı: 65 - 70 Metin Dili: Türkçe İndeks Tarihi: 16-06-2021

Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi

Öz:

Sempatik oftalmi, penetran oküler travma veya cerrahi girişimi takiben gelişen, nadir görülen, bilateral, tekrarlayıcı, granülomatöz panüveittir. Etyolojisi tam olarak anlaşılamamış olmakla birlikte cerrahi geçiren ya da travmaya maruz kalan gözde açığa çıkan oküler antijenlere karşı gelişen otoimmün reaksiyon olduğu düşünülmektedir. Tanı hikaye ve klinik bulgulara dayanılarak konur. Primer inflamasyon sahası koroid olmakla birlikte optik sinir başında ödem görülmesi, vitritis, eksudatif retina dekolmanı, koroid kalınlığında artış, koroidal infiltrasyonlar ve Dalen-Fuchs nodülleri gibi arka segment bulguları ve özellikle kronik tekrarlayan fazda görülen granülomatöz ön üveit bulguları hastalığın en önemli klinik özellikleridir. Kortikosteroid ve immünsüpresif ajanlarla hızlı ve etkili bir tedavi iyi görsel sonuçlar elde edilmesinde oldukça önemlidir. Hastalığın önlenmesinde ve prognozun belirlenmesinde enükleasyonun yeri tartışmalıdır.

Anahtar Kelime:

Sympathetic Ophthalmia; Clinical Findings, Diagnosis and Treatment

Öz:

Sympathetic ophthalmia is a rare, bilateral, recurrent, granulomatous panuveitis following penetrating ocular trauma orsurgery. Although the etiology is not well understood, it is thought that there is an autoimmune reaction against ocular anti gens that are exposed from the inciting eye. Diagnosis is based on history and clinical findings. As well as the primary site ofinflammation is choroid, posterior segment findings such as papillitis, vitritis, exudative retinal detachment, increased cho roidal thickness, choroidal infiltrations, and Dalen-Fuchs nodules and granulomatous anterior uveitis especially in chronicrecurrent phase are the most important clinical features of the disease. Prompt and effective treatment with corticosteroidsand immunosuppressive agents is very important in achieving good visual results. The role of enucleation in the preventionand prognosis of the disease is controversial.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Bibliyografik

1. Sen HN, Nussenblatt RB. Sympathetic ophthalmia: what have we learned? Am J Ophthalmol. 2009;148(5):632-3.
2. Albert DM, Diaz-Rohena R. A historical review of sympathetic ophthalmia and its epidemiology. Surv Ophthalmol. 1989;34(1):1-14.
3. Marak GE, Jr. Recent advances in sympathetic ophthalmia. Surv Ophthalmol. 1979;24(3):141-56.
4. Chu XK, Chan CC. Sympathetic ophthalmia: to the twenty-first century and beyond. J Ophthalmic Inflamm Infect. 2013;3(1):49.
5. Kilmartin DJ, Dick AD, Forrester JV. Prospective surveillance of sympathetic ophthalmia in the UK and Republic of Ireland. Br J Ophthalmol. 2000;84(3):259-63.
6. Su DH, Chee SP. Sympathetic ophthalmia in Singapore: new trends in an old disease. Graefes Arch Clin Exp Ophthalmol. 2006;244(2):243-7.
7. Vote BJ, Hall A, Cairns J, Buttery R. Changing trends in sympathetic ophthalmia. Clin Exp Ophthalmol. 2004;32(5):542-5.
8. Castiblanco CP, Adelman RA. Sympathetic ophthalmia. Graefes Arch Clin Exp Ophthalmol. 2009;247(3):289-302.
9. Gasch AT, Foster CS, Grosskreutz CL, Pasquale LR. Postoperative sympathetic ophthalmia. Int Ophthalmol Clin. 2000;40(1):69-84.
10. Brouzas D, Koutsandrea C, Moschos M, Papadimitriou S, Ladas I, Apostolopoulos M. Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin) for AMD followed by controlateral sympathetic ophthalmia. Clin Ophthalmol. 2009;3:457-9.
11. Roberts MA, Rajkumar V, Morgan G, Laws D. Sympathetic ophthalmia secondary to cyclodiode laser in a 10-year-old boy. J AAPOS. 2009;13(3):299-300.
12. Fries PD, Char DH, Crawford JB, Waterhouse W. Sympathetic ophthalmia complicating helium ion irradiation of a choroidal melanoma. Arch Ophthalmol. 1987;105(11):1561-4.
13. Ahmad N, Soong TK, Salvi S, Rudle PA, Rennie IG. Sympathetic ophthalmia after ruthenium plaque brachytherapy. Br J Ophthalmol. 2007;91(3):399-401.
14. Lubin JR, Albert DM, Weinstein M. Sixty-five years of sympathetic ophthalmia. A clinicopathologic review of 105 cases (1913--1978). Ophthalmology. 1980;87(2):109-21.
15. Goto H, Rao NA. Sympathetic ophthalmia and Vogt-Koyanagi-Harada syndrome. Int Ophthalmol Clin. 1990;30(4):279-85.
16. Zaharia MA, Lamarche J, Laurin M. Sympathetic uveitis 66 years after injury. Can J Ophthalmol. 1984;19(5):240-3.
17. Chan CC, Roberge RG, Whitcup SM, Nussenblatt RB. 32 cases of sympathetic ophthalmia. A retrospective study at the National Eye Institute, Bethesda, Md., from 1982 to 1992. Arch Ophthalmol. 1995;113(5):597-600.
18. Lin X, Zhong X. [A clinical analysis of 30 cases of sympathetic ophthalmia]. Yan Ke Xue Bao. 1996;12(4):191-2.
19. Wang Y, Chan CC. Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. J Ophthalmol. 2014;2014:157803.
20. Kilmartin DJ, Wilson D, Liversidge J, Dick AD, Bruce J, Acheson RW, et al. Immunogenetics and clinical phenotype of sympathetic ophthalmia in British and Irish patients. Br J Ophthalmol. 2001;85(3):281-6.
21. Davis JL, Mittal KK, Freidlin V, Mellow SR, Optican DC, Palestine AG, et al. HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. Ophthalmology. 1990;97(9):1137-42.
22. Chan CC, Nussenblatt RB, Fujikawa LS, Palestine AG, Stevens G, Jr., Parver LM, et al. Sympathetic ophthalmia. Immunopathological findings. Ophthalmology. 1986;93(5):690-5.
23. Shah DN, Piacentini MA, Burnier MN, McLean IW, Nussenblatt RB, Chan CC. Inflammatory cellular kinetics in sympathetic ophthalmia a study of 29 traumatized (exciting) eyes. Ocul Immunol Inflamm. 1993;1(3):255-62.
24. Jakobiec FA, Marboe CC, Knowles DM, 2nd, Iwamoto T, Harrison W, Chang S, et al. Human sympathetic ophthalmia. An analysis of the inflammatory infiltrate by hybridoma-monoclonal antibodies, immunochemistry, and correlative electron microscopy. Ophthalmology. 1983;90(1):76-95.
25. Reynard M, Riffenburgh RS, Minckler DS. Morphological variation of Dalen-Fuchs nodules in sympathetic ophthalmia. Br J Ophthalmol. 1985;69(3):197-201.
26. Croxatto JO, Rao NA, McLean IW, Marak GE. Atypical histopathologic features in sympathetic ophthalmia. A study of a hundred cases. Int Ophthalmol. 1982;4(3):129-35.
27. Chang GC, Young LH. Sympathetic ophthalmia. Semin Ophthalmol. 2011;26(4-5):316-20.
28. Gupta V, Gupta A, Dogra MR. Posterior sympathetic ophthalmia: a single centre long-term study of 40 patients from North India. Eye (Lond). 2008;22(12):1459-64.
29. Yang P, Liu S, Zhong Z, Du L, Ye Z, Zhou W, et al. Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt-Koyanagi-Harada Disease in Chinese Patients. Ophthalmology. 2019.
30. Burkholder BM, Dunn JP. Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. JAMA Ophthalmol. 2014;132(10):1220.
31. Sharp DC, Bell RA, Patterson E, Pinkerton RM. Sympathetic ophthalmia. Histopathologic and fluorescein angiographic correlation. Arch Ophthalmol. 1984;102(2):232-5.
32. Castiblanco C, Adelman RA. Imaging for sympathetic ophthalmia: impact on the diagnosis and management. Int Ophthalmol Clin. 2012;52(4):173- 81.
33. Casella AM, Farah ME, Martins MC, Hasegawa A, Oguido AP. Sympathetic ophthalmia - histopathological correlation with fluorescein and indocyanine green angiography: case report. Arq Bras Oftalmol. 2008;71(6):886-9.
34. Saatci AO, Pasa E, Soylev MF, Kocak N, Durak I, Kaynak S. Sympathetic ophthalmia and indocyanine green angiography. Arch Ophthalmol. 2004;122(10):1568-9.
35. Bernasconi O, Auer C, Zografos L, Herbort CP. Indocyanine green angiographic findings in sympathetic ophthalmia. Graefes Arch Clin Exp Ophthalmol. 1998;236(8):635-8.
36. Muakkassa NW, Witkin AJ. Spectral-domain optical coherence tomography of sympathetic ophthalmia with Dalen-Fuchs nodules. Ophthalmic Surg Lasers Imaging Retina. 2014;45(6):610-2.
37. Mahajan S, Invernizzi A, Agrawal R, Biswas J, Rao NA, Gupta V. Multimodal Imaging in Sympathetic Ophthalmia. Ocul Immunol Inflamm. 2017;25(2):152-9.
38. Rao NA, Marak GE. Sympathetic ophthalmia simulating vogt-Koyanagi-Harada’s disease: a clinico-pathologic study of four cases. Jpn J Ophthalmol. 1983;27(3):506-11.
39. Tan XL, Seen S, Dutta Majumder P, Ganesh SK, Agarwal M, Soni A, et al. Analysis of 130 Cases of Sympathetic Ophthalmia - A Retrospective Multicenter Case Series. Ocul Immunol Inflamm. 2018:1-8.
40. Bilyk JR. Enucleation, evisceration, and sympathetic ophthalmia. Curr Opin Ophthalmol. 2000;11(5):372-86.
41. Galor A, Davis JL, Flynn HW, Jr., Feuer WJ, Dubovy SR, Setlur V, et al. Sympathetic ophthalmia: incidence of ocular complications and vision loss in the sympathizing eye. Am J Ophthalmol. 2009;148(5):704-10 e2.
42. Reynard M, Riffenburgh RS, Maes EF. Effect of corticosteroid treatment and enucleation on the visual prognosis of sympathetic ophthalmia. Am J Ophthalmol. 1983;96(3):290-4.
43. Patel SS, Dodds EM, Echandi LV, Couto CA, Schlaen A, Tessler HH, et al. Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. Ophthalmology. 2014;121(2):596- 602.
44. Payal AR, Foster CS. Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. Ocul Immunol Inflamm. 2017;25(2):190- 5.
45. Hakin KN, Pearson RV, Lightman SL. Sympathetic ophthalmia: visual results with modern immunosuppressive therapy. Eye (Lond). 1992;6 ( Pt 5):453-5.
46. Yang CS, Liu JH. Chlorambucil therapy in sympathetic ophthalmia. Am J Ophthalmol. 1995;119(4):482-8.
47. Soheilian M, Jabbarpourbonyadi M, Soheilian R, Peyman GA. Bilateral uveitis after phakic intraocular lens implantation and management with adalimumab. J Cataract Refract Surg. 2012;38(6):1094-6.
48. Hiyama T, Harada Y, Kiuchi Y. Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab. Am J Ophthalmol Case Rep. 2019;14:1-4.
49. Menghini M, Frimmel SA, Windisch R, Meier FM. Efficacy of infliximab therapy in two patients with sympathetic ophthalmia. Klin Monbl Augenheilkd. 2011;228(4):362-3.
50. Kim JB, Jeroudi A, Angeles-Han ST, Grossniklaus HE, Yeh S. Adalimumab for pediatric sympathetic ophthalmia. JAMA Ophthalmol. 2014;132(8):1022-4.
51. Gupta SR, Phan IT, Suhler EB. Successful treatment of refractory sympathetic ophthalmia in a child with infliximab. Arch Ophthalmol. 2011;129(2):250-2.
52. Ziahosseini K, Newman WD. Challenges of managing sympathetic ophthalmia in a young child and the role of infliximab. J Pediatr Ophthalmol Strabismus. 2011;48 Online:e34-6.
53. Jonas JB. Intravitreal triamcinolone acetonide for treatment of sympathetic ophthalmia. Am J Ophthalmol. 2004;137(2):367-8.
54. Ozdemir H, Karacorlu M, Karacorlu S. Intravitreal triamcinolone acetonide in sympathetic ophthalmia. Graefes Arch Clin Exp Ophthalmol. 2005;243(7):734-6.
55. Sandinha MT, Lake S. Periocular injections of triamcinolone for sympathetic ophthalmia. Clin Exp Ophthalmol. 2010;38(8):819-21.
56. Mahajan VB, Gehrs KM, Goldstein DA, Fischer DH, Lopez JS, Folk JC. Management of sympathetic ophthalmia with the fluocinolone acetonide implant. Ophthalmology. 2009;116(3):552-7 e1.
57. Mansour AM. Dexamethasone Implant as Sole Therapy in Sympathetic Ophthalmia. Case Rep Ophthalmol. 2018;9(2):257-63.
58. Wocker L, Januschowski K. [Steroid implant in treatment of sympathetic ophthalmia : Intravitreal implant of dexamethasone in cystoid macular edema in the context of sympathetic ophthalmia]. Ophthalmologe. 2019;116(4):380-3.

APA	Eser-Ozturk H (2021). Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. , 65 - 70.
Chicago	Eser-Ozturk Hilal Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. (2021): 65 - 70.
MLA	Eser-Ozturk Hilal Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. , 2021, ss.65 - 70.
AMA	Eser-Ozturk H Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. . 2021; 65 - 70.
Vancouver	Eser-Ozturk H Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. . 2021; 65 - 70.
IEEE	Eser-Ozturk H "Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi." , ss.65 - 70, 2021.
ISNAD	Eser-Ozturk, Hilal. "Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi". (2021), 65-70.

APA	Eser-Ozturk H (2021). Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. Güncel Retina Dergisi, 5(1), 65 - 70.
Chicago	Eser-Ozturk Hilal Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. Güncel Retina Dergisi 5, no.1 (2021): 65 - 70.
MLA	Eser-Ozturk Hilal Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. Güncel Retina Dergisi, vol.5, no.1, 2021, ss.65 - 70.
AMA	Eser-Ozturk H Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. Güncel Retina Dergisi. 2021; 5(1): 65 - 70.
Vancouver	Eser-Ozturk H Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi. Güncel Retina Dergisi. 2021; 5(1): 65 - 70.
IEEE	Eser-Ozturk H "Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi." Güncel Retina Dergisi, 5, ss.65 - 70, 2021.
ISNAD	Eser-Ozturk, Hilal. "Sempatik Oftalmi ile İlişkili Üveit; Klinik, Tanı ve Tedavi". Güncel Retina Dergisi 5/1 (2021), 65-70.