Yıl: 2020 Cilt: 29 Sayı: 2 Sayfa Aralığı: 115 - 121 Metin Dili: İngilizce DOI: 10.5152/turkjnephrol.2020.3686 İndeks Tarihi: 16-06-2021

Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients

Öz:
Objective: Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipose tissue and macrophages. It regulates cholesterol trafficking and is involved in atherosclerosis formation. A-FABP levels are associated with cardiovascular diseases (CVDs) in patients with or without chronic kidney disease. In this study, we evaluated A-FABP levels in healthy controls and hemodialysis (HD) patients and compared the results with C-reactive protein (CRP) and interleukin-6 (IL-6) levels to determine their relationship with systemic inflammation.Materials and Methods: The study comprised 23 healthy controls and 70 HD patients, excluding individuals with an active infection, malignancy, anorexia, obesity, and hypo- or hyperthyroidism. Demographic features, laboratory findings, A-FABP levels, and levels of inflammatory markers were evaluated between and within the groups.Results: Levels of A-FABP and inflammatory markers were significantly higher in HD patients. In the HD group, 20% of the patients had documented CVD. Levels of A-FABP and inflammatory markers were similar in nondiabetic and diabetic HD patients. Age was negatively correlated with A-FABP levels. Presence of diabetes was not correlated with A-FABP. Serum CRP and IL-6 levels were significantly correlated with A-FABP levels (r=0.354, p=0.003 and r=0.393, p=0.001, respectively).Conclusion: A-FABP levels are elevated in HD patients. Systemic inflammation is significantly related to A-FABP levels in both nondiabetic and diabetic HD patients and decreases with age. Findings of this study support the adverse cardiovascular effects of systemic inflammation in HD patients.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Korucu B, Derici M, Deger S, Helvaci O, Cokay A, Elbeg Ş, DERICI U (2020). Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. , 115 - 121. 10.5152/turkjnephrol.2020.3686
Chicago Korucu Berfu,Derici Mehmet Kürşat,Deger Serpil Muge,Helvaci Ozant,Cokay Abdurrahman,Elbeg Şehri,DERICI ULVER Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. (2020): 115 - 121. 10.5152/turkjnephrol.2020.3686
MLA Korucu Berfu,Derici Mehmet Kürşat,Deger Serpil Muge,Helvaci Ozant,Cokay Abdurrahman,Elbeg Şehri,DERICI ULVER Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. , 2020, ss.115 - 121. 10.5152/turkjnephrol.2020.3686
AMA Korucu B,Derici M,Deger S,Helvaci O,Cokay A,Elbeg Ş,DERICI U Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. . 2020; 115 - 121. 10.5152/turkjnephrol.2020.3686
Vancouver Korucu B,Derici M,Deger S,Helvaci O,Cokay A,Elbeg Ş,DERICI U Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. . 2020; 115 - 121. 10.5152/turkjnephrol.2020.3686
IEEE Korucu B,Derici M,Deger S,Helvaci O,Cokay A,Elbeg Ş,DERICI U "Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients." , ss.115 - 121, 2020. 10.5152/turkjnephrol.2020.3686
ISNAD Korucu, Berfu vd. "Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients". (2020), 115-121. https://doi.org/10.5152/turkjnephrol.2020.3686
APA Korucu B, Derici M, Deger S, Helvaci O, Cokay A, Elbeg Ş, DERICI U (2020). Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. Turkish journal of nephrology (Online), 29(2), 115 - 121. 10.5152/turkjnephrol.2020.3686
Chicago Korucu Berfu,Derici Mehmet Kürşat,Deger Serpil Muge,Helvaci Ozant,Cokay Abdurrahman,Elbeg Şehri,DERICI ULVER Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. Turkish journal of nephrology (Online) 29, no.2 (2020): 115 - 121. 10.5152/turkjnephrol.2020.3686
MLA Korucu Berfu,Derici Mehmet Kürşat,Deger Serpil Muge,Helvaci Ozant,Cokay Abdurrahman,Elbeg Şehri,DERICI ULVER Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. Turkish journal of nephrology (Online), vol.29, no.2, 2020, ss.115 - 121. 10.5152/turkjnephrol.2020.3686
AMA Korucu B,Derici M,Deger S,Helvaci O,Cokay A,Elbeg Ş,DERICI U Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. Turkish journal of nephrology (Online). 2020; 29(2): 115 - 121. 10.5152/turkjnephrol.2020.3686
Vancouver Korucu B,Derici M,Deger S,Helvaci O,Cokay A,Elbeg Ş,DERICI U Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients. Turkish journal of nephrology (Online). 2020; 29(2): 115 - 121. 10.5152/turkjnephrol.2020.3686
IEEE Korucu B,Derici M,Deger S,Helvaci O,Cokay A,Elbeg Ş,DERICI U "Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients." Turkish journal of nephrology (Online), 29, ss.115 - 121, 2020. 10.5152/turkjnephrol.2020.3686
ISNAD Korucu, Berfu vd. "Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients". Turkish journal of nephrology (Online) 29/2 (2020), 115-121. https://doi.org/10.5152/turkjnephrol.2020.3686