Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances
Yıl: 2020 Cilt: 17 Sayı: 3 Sayfa Aralığı: 149 - 154 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2020.38924 İndeks Tarihi: 16-06-2021
Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances
Öz: Objective: To investigate pregnancy outcomes and compare the clinical characteristics of coronavirus 2019 (COVID-19) disease in pregnant and age-matched non-pregnant women.Materials and Methods: Hospital records of four tertiary care centers were reviewed retrospectively. The subjects comprised 188 pregnant patients and 799 non-pregnant women who were admitted to these hospitals.Results: Pregnancy significantly affected the clinical severity of COVID-19 and this effect was more prominent in pregnant women at >20 weeks gestation (p<0.001). Rates of oxygen support (10.1% vs 4.8%; p≤0.001), intensive care unit admission (3.2% vs 0.6%; p=0.009), presence of fever (12.8% vs 4.4%; p<0.001), tachypnea (7.0% vs 2.4%; p=0.003) and tachycardia (16.0% vs 1.9%; p<0.001) were significantly more frequent in pregnant women compared with non-pregnant women. Pregnancy was strongly associated with the need for oxygen support [relative risk (RR), 2.125; 95% confidence interval (CI): 1.25-3.60] and admission to the intensive care unit (RR, 5.1; 95% CI: 1.57-16.53) compared with non-pregnant women. Some 14.4% of the pregnant women had co-morbidities. Sixty of the 188 pregnant women (31.9%) delivered during the Severe Acute Respiratory syndrome coronavirus-2 infection, 11 (18.3%) had vaginal deliveries and 49 (81.7%) were by cesarean section. Of these 60 deliveries, 40 (66.7%) were <37 weeks gestation.Conclusion: Pregnancy worsens the morbidity of COVID-19 and this effect seems to increase as the pregnancy advances, but not the mortality rate.
Anahtar Kelime: Gebelik COVID-19 morbiditesini kötüleştirmekte ve bu etki gebelik ilerledikçe daha belirgin hal almaktadır
Öz: Amaç: Gebe ve aynı yaş grubundaki gebe olmayan kadınlarda koronavirüs 2019 (COVID-19) kliniğinin karşılaştırılmasıdır.Gereç ve Yöntemler: Dört tersiyer merkezin tıbbi kayıtları geriye dönük incelendi. Çalışma kapsamına 188 gebe ve 799 gebe olmayan COVID-19 tanısı konfirme edilmiş kadın dahil edildi.Bulgular: Gebelik COVID-19 kliniğini istatistiksel olarak önemli ölçüde etkilemiştir. Bu etki 20. gebelik haftasından sonra artmaktadır (p<0,001). Oksijen desteği (%10,1 vs. %4,8; p≤0,001), yoğun bakımda yatış (%3,2 vs. %0,6; p=0,009), ateş (%12,8 vs. %4,4; p<0,001), taşipne (%7,0 vs. %2,4; p=0,003) ve taşikardi (%16 vs. %1,9; p<0,001) oranları gebe grupta daha yüksekti. Gebelik durumu oksijen ihtiyacı [rölatif risk (RR), 2,125; %95 güven aralığı (GA), 1,25-3,60] ve yoğun bakım yatışı (RR: 5,1; %95 GA: 1,57-16,53) ile ilişkili bulundu. Gebelerin %14,4’ü komorbid hastalardı. Yüz seksen sekiz gebenin hastalık seyri esnasında 60’ı (%31,9) doğum yaptı. Bu doğumların 11’i (%18,3) vajinal, 49’u (%81,7) sezaryen ile gerçekleşti. Doğumların 40’ında (%66,7) 37. gebelik haftası tamamlanmamıştı.Sonuç: Gebelik COVID-19 morbiditesini kötüleştirmekte ve bu etki gebelik ilerledikçe daha belirgin hal almaktadır fakat mortalite oranlarında değişiklik saptanmamıştır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Tug N, YASSA M, Köle E, sakin o, Cakir kole M, KARATEKE A, Yiyit N, yavuz e, Birol P, budak d, kol ö, emir e (2020). Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. , 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| Chicago | Tug Niyazi,YASSA MURAT,Köle Emre,sakin onder,Cakir kole Merve,KARATEKE ATEŞ,Yiyit Nurettin,yavuz emre,Birol Pınar,budak doğuş,kol ömer,emir edip Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. (2020): 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| MLA | Tug Niyazi,YASSA MURAT,Köle Emre,sakin onder,Cakir kole Merve,KARATEKE ATEŞ,Yiyit Nurettin,yavuz emre,Birol Pınar,budak doğuş,kol ömer,emir edip Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. , 2020, ss.149 - 154. 10.4274/tjod.galenos.2020.38924 |
| AMA | Tug N,YASSA M,Köle E,sakin o,Cakir kole M,KARATEKE A,Yiyit N,yavuz e,Birol P,budak d,kol ö,emir e Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. . 2020; 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| Vancouver | Tug N,YASSA M,Köle E,sakin o,Cakir kole M,KARATEKE A,Yiyit N,yavuz e,Birol P,budak d,kol ö,emir e Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. . 2020; 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| IEEE | Tug N,YASSA M,Köle E,sakin o,Cakir kole M,KARATEKE A,Yiyit N,yavuz e,Birol P,budak d,kol ö,emir e "Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances." , ss.149 - 154, 2020. 10.4274/tjod.galenos.2020.38924 |
| ISNAD | Tug, Niyazi vd. "Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances". (2020), 149-154. https://doi.org/10.4274/tjod.galenos.2020.38924 |
| APA | Tug N, YASSA M, Köle E, sakin o, Cakir kole M, KARATEKE A, Yiyit N, yavuz e, Birol P, budak d, kol ö, emir e (2020). Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. Turkish Journal of Obstetrics and Gynecology, 17(3), 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| Chicago | Tug Niyazi,YASSA MURAT,Köle Emre,sakin onder,Cakir kole Merve,KARATEKE ATEŞ,Yiyit Nurettin,yavuz emre,Birol Pınar,budak doğuş,kol ömer,emir edip Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. Turkish Journal of Obstetrics and Gynecology 17, no.3 (2020): 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| MLA | Tug Niyazi,YASSA MURAT,Köle Emre,sakin onder,Cakir kole Merve,KARATEKE ATEŞ,Yiyit Nurettin,yavuz emre,Birol Pınar,budak doğuş,kol ömer,emir edip Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. Turkish Journal of Obstetrics and Gynecology, vol.17, no.3, 2020, ss.149 - 154. 10.4274/tjod.galenos.2020.38924 |
| AMA | Tug N,YASSA M,Köle E,sakin o,Cakir kole M,KARATEKE A,Yiyit N,yavuz e,Birol P,budak d,kol ö,emir e Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. Turkish Journal of Obstetrics and Gynecology. 2020; 17(3): 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| Vancouver | Tug N,YASSA M,Köle E,sakin o,Cakir kole M,KARATEKE A,Yiyit N,yavuz e,Birol P,budak d,kol ö,emir e Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances. Turkish Journal of Obstetrics and Gynecology. 2020; 17(3): 149 - 154. 10.4274/tjod.galenos.2020.38924 |
| IEEE | Tug N,YASSA M,Köle E,sakin o,Cakir kole M,KARATEKE A,Yiyit N,yavuz e,Birol P,budak d,kol ö,emir e "Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances." Turkish Journal of Obstetrics and Gynecology, 17, ss.149 - 154, 2020. 10.4274/tjod.galenos.2020.38924 |
| ISNAD | Tug, Niyazi vd. "Pregnancy worsens the morbidity of COVID-19 and this effect becomes more prominent as pregnancy advances". Turkish Journal of Obstetrics and Gynecology 17/3 (2020), 149-154. https://doi.org/10.4274/tjod.galenos.2020.38924 |
