TY  - JOUR
TI  - Persimmon (Diospyros Kaki L.) Alleviates Ethanol-Induced Gastric Ulcer in Rats
AB  - Objective: The worldwide incidence of a gastric ulcer is high, most often as a result of useof nonsteroidal anti-inflammatory drugs, excessive alcohol consumption, or Helicobacterpylori infection. An ethanol-based gastric ulcer model in rats was used to examine the effectof persimmon (Diospyros kaki L.) extract as a potential form of treatment.Methods: Two dosages of persimmon extract were applied in a gastric ulcer model createdwith 5 mL/kg ethanol in Wistar albino rats. Histopathological and biochemical methods wereused to assess any gastroprotective effects.Results: Persimmon extract significantly decreased the level of the cytokines interleukin(IL)-10, IL-6, tumor necrosis factor alpha (TNF-α) and IL-1 beta. Caspase-3 and nuclearfactor kappa B expression was also significantly reduced.Conclusion: Persimmon fruit extract demonstrated a gastroprotective effect in an ethanol-based gastric ulcer model in rats.
AU  - Ekinci Akdemir, Fazile Nur
AU  - Capanoglu, Esra
AU  - Eraslan, Ersen
AU  - Bozhuyuk, Mehmet Ramazan
AU  - tanyeli, ayhan
AU  - Özkan, Gülay
AU  - KURT, Nezahat
AU  - TOKAY, Erdem
AU  - guler, mustafa can
DO  - 10.14744/scie.2020.94546
PY  - 2021
JO  - Southern Clinics of Istanbul Eurasia
VL  - 32
IS  - 1
SN  - 2587-0998
SP  - 1
EP  - 7
DB  - TRDizin
UR  - http://search/yayin/detay/423511
ER  -