Yıl: 2021 Cilt: 59 Sayı: 1 Sayfa Aralığı: 53 - 57 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2021.6584 İndeks Tarihi: 19-06-2021

Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome

Öz:
Aim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women during the reproductive ages. The purpose of this study was to investigate the chronotype and sleep quality of PCOS patients.Methods: Volunteering nulliparous participants who were diagnosed with PCOS and a convenience sample of healthy controls without accompanying chronic medical conditions who presented to the Bezmialem University gynecology outpatient clinic were enrolled in the study. Participants were asked to fill out the Turkish versions of Morningness Eveningness Questionnaire (MEQ) and Pittsburgh Sleep Quality index Questionnaire (PSQIQ). Results: There were 111 participants in the PCOS group and 108 participants in the healthy control group. Both groups were similar in age (p=0.24) and body mass index (p=0.9). The prevalance of hirsutism (mFG ≥8) was 33.3% among PCOS patients. Subjective sleep quality (<0.001), sleep latency (<0.001), habitual sleep efficiency (0.003), utilization of sleep medication (0.03) and daytime dysfunction (<0.001) scores were significantly different between the groups. In the PCOS group, MEQ score was inversely correlated with the mFG score and fT levels. There was a negative correlation between MEQ-mFG (r=-0.59, p<0.001).Conclusion: PCOS patients were more prone to eveningness chronotype and had worse sleep quality compared to controls. Furthermore PCOS patients with hirsutism were more evening oriented and had more difficulty falling asleep compared to those without hyperandrogenism.
Anahtar Kelime:

Polikistik Over Sendromu Olan Hastalarda Kronotip ve Uyku Kalitesi Değerlendirmesi

Öz:
Amaç: Polikistik Over Sendromu (PKOS) reprodüktif çağdaki kadınlarda en sık izlenen endokrin problemdir. Bu çalışmamızdaki amacımız PKOS hastalarının kronotipini belirlemek ve uyku kalitelerini değerlendirmektir. Yöntemler: Daha önce doğum yapmamış PKOS hastaları ve herhangi bir kronik sağlık problemi bulunmayan Bezmialem Üniversitesi jinekoloji polikliniğine başvuran gönüllü erişkinler çalışmaya dahil edilmişlerdir. Çalışmaya dahil edilenlerden Türkçe validasyonu olan Sabahçıl Akşamcıl (MEQ) ve Pittsburgh Uyku Kalitesi indeksi (PSQIQ) ölçeklerini doldurmaları istenmiştir. Bulgular: PKOS grubunda 111, kontrol grubunda 108 gönüllü yer almıştır.Her iki grup da yaş (p=0,24) ve vücut kitle indeksi (VKİ) (p=0.9) açısından benzerdi. PKOS hastaları arasında hirsutizm prevalansı (mFG>8) %33,3 idi. Subjektif uyku kalitesi (p<0,001), uykuya dalama süresi (p<0,001), alışılmış uyku etkinliği (p=0,003), uyku ilacı kullanımı (p=0,03) ve gündüz işlev bozukluğu (p<0,001) anlamlı olarak PCOS grubunda daha kötüydü. PKOS grubunda MEQ skoru mFG skoru ile negatif korelasyon MEQ-mFG (r=-0,59, p<0,001) gösteriyordu.Sonuç: PKOS kontrol grubu ile karşılaştırıldığında akşamcıl kronotipe daha yatkındılar. Hirsutizm mevcut olan PKOS hastaları ise hirsutizm olmayan hastalara göre daha fazla akşamcıl kronotipe sahipti ve uykuya dalma konusunda daha fazla problem yaşıyordu.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • 1. Carmina E, Azziz R. Diagnosis, phenotype, and prevalence of polycystic ovary syndrome. Fertil Steril 2006;86:7-8.
  • 2. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
  • 3. Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman’s long-term health using data linkage. J Clin Endocrinol Metab 2015;100:911-9.
  • 4. Twig G, Yaniv G, Levine H, et al. Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood. N Engl J Med 2016;374:2430-40.
  • 5. Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev 2010;90:1063-102.
  • 6. Adan A, Archer SN, Hidalgo MP, Di Milia L, Natale V, Randler C. Circadian typology: a comprehensive review. Chronobiol Int 2012;29:1153-75.
  • 7. Sahbaz C, Devetzioglou T, Ozcelik AM, Kırpınar İ. Circadian preferences are associated with vegetative symptoms and comorbid medical diseases in patients with major depression. Biol Rhythm Res 2019;50:703-17.
  • 8. Díaz-Morales JF. Morning and evening-types: exploring their personality styles. Pers Individ Dif. 2007:43:769-78.
  • 9. Takmaz T, Unal B, Ozcan P, et al. Are chronotype and subjective sleep quality associated with preeclampsia and preterm birth?, Biological Rhythm Research.2020;1-13.
  • 10. Steptoe A, O’Donnell K, Marmot M, Wardle J. Positive affect, psychological well-being, and good sleep. J Psychosom Res 2008;64:409-15.
  • 11. Jennings JR, Muldoon MF, Hall M, Buysse DJ, Manuck SB. Self-reported sleep quality is associated with the metabolic syndrome. Sleep 2007;30:219-23.
  • 12. Okubo N, Matsuzaka M, Takahashi I, et al. Relationship between self-reported sleep quality and metabolic syndrome in general population. BMC Public Health 2014;14:562.
  • 13. Laposky AD, Bass J, Kohsaka A, Turek FW. Sleep and circadian rhythms: key components in the regulation of energy metabolism. FEBS Lett 2008;582:142-51.
  • 14. Tuomilehto H, Peltonen M, Partinen M, et al. Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: The Finnish Diabetes Prevention Study. Diabetes Care 2009;32:1965-71.
  • 15.Ehrmann DA. Metabolic dysfunction in pcos: Relationship to obstructive sleep apnea. Steroids 2012;77:290-4.
  • 16. Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:1175-80.
  • 17.Subramanian S, Desai A, Joshipura M, Surani S. Practice patterns of screening for sleep apnea in physicians treating PCOS patients. Sleep Breath 2007;12:233-7.
  • 18. Balen AH, Laven JS, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update 2003;9:505-14
  • 19. Nicandri KF, Hoeger K. Diagnosis and treatment of polycystic ovarian syndrome in adolescents. Curr Opin Endocrinol Diabetes Obes 2012;19:497-504.
  • 20. FERRIMAN D, GALLWEY JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-7.
  • 21. Agargun MY, Cilli AS, Boysan M, et al. Turkish version of morningness-eveningness questionnaire (MEQ). Sleep Hypn. 2007:9:16
  • 22. Ağargün MY, Kara H, Anlar Ö. The validity and reliability of the Pittsburgh Sleep Quality Index. Turk Psikiyatri Derg. 1996:7:107-115.
  • 23. Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol 1976;4:97-110.
  • 24. Partonen T. Chronotype and health outcomes. Curr Sleep Med 2015;1:205–11.
  • 25. Yu JH, Yun CH, Ahn JH, et al. Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults. J Clin Endocrinol Metab 2015;100:1494-502.
  • 26. Fernandez RC, Moore VM, Van Ryswyk EM, et al. Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies. Nat Sci Sleep 2018;10:45-64.
  • 27. Tasali E, Van Cauter E, Ehrmann DA. Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome. J Clin Endocrinol Metab 2006;91:36-42.
  • 28. Andersen ML, Alvarenga TF, Mazaro-Costa R, Hachul HC, Tufik S. The association of testosterone, sleep, and sexual function in men and women. Brain Res 2011;1416:80-104.
  • 29. Vgontzas AN, Legro RS, Bixler EO, Grayev A, Kales A, Chrousos GP. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab 2001;86:517-20.
  • 30. Moran LJ, March WA, Whitrow MJ, Giles LC, Davies MJ, Moore VM. Sleep disturbances in a community-based sample of women with polycystic ovary syndrome. Hum Reprod 2015;30:466-72.
  • 31. Cistulli PA, Grunstein RR, Sullivan CE. Effect of testosterone administration on upper airway collapsibility during sleep. Am J Respir Crit Care Med 1994;149:530-2.
  • 32. de Sousa G, Schlüter B, Menke T, Trowitzsch E, Andler W, Reinehr T. Relationships between polysomnographic variables, parameters of glucose metabolism, and serum androgens in obese adolescents with polycystic ovarian syndrome. J Sleep Res 2011;20:472-8.
  • 33. Nelson VL, Qin KN, Rosenfield RL, et al. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:5925-33.
  • 34. Nandalike K, Agarwal C, Strauss T, et al. Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome. Sleep Med 2012;13:1307-12.
APA Gokmen Karasu A, Sahbaz C, EREN DOĞU Z, Takmaz T, cali ozturk h, TANOĞLU F (2021). Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. , 53 - 57. 10.4274/haseki.galenos.2021.6584
Chicago Gokmen Karasu Ayse Filiz,Sahbaz Cigdem,EREN DOĞU Zeynep Filiz,Takmaz Taha,cali ozturk halime,TANOĞLU FATMA BAŞAK Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. (2021): 53 - 57. 10.4274/haseki.galenos.2021.6584
MLA Gokmen Karasu Ayse Filiz,Sahbaz Cigdem,EREN DOĞU Zeynep Filiz,Takmaz Taha,cali ozturk halime,TANOĞLU FATMA BAŞAK Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. , 2021, ss.53 - 57. 10.4274/haseki.galenos.2021.6584
AMA Gokmen Karasu A,Sahbaz C,EREN DOĞU Z,Takmaz T,cali ozturk h,TANOĞLU F Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. . 2021; 53 - 57. 10.4274/haseki.galenos.2021.6584
Vancouver Gokmen Karasu A,Sahbaz C,EREN DOĞU Z,Takmaz T,cali ozturk h,TANOĞLU F Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. . 2021; 53 - 57. 10.4274/haseki.galenos.2021.6584
IEEE Gokmen Karasu A,Sahbaz C,EREN DOĞU Z,Takmaz T,cali ozturk h,TANOĞLU F "Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome." , ss.53 - 57, 2021. 10.4274/haseki.galenos.2021.6584
ISNAD Gokmen Karasu, Ayse Filiz vd. "Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome". (2021), 53-57. https://doi.org/10.4274/haseki.galenos.2021.6584
APA Gokmen Karasu A, Sahbaz C, EREN DOĞU Z, Takmaz T, cali ozturk h, TANOĞLU F (2021). Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. Haseki Tıp Bülteni, 59(1), 53 - 57. 10.4274/haseki.galenos.2021.6584
Chicago Gokmen Karasu Ayse Filiz,Sahbaz Cigdem,EREN DOĞU Zeynep Filiz,Takmaz Taha,cali ozturk halime,TANOĞLU FATMA BAŞAK Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. Haseki Tıp Bülteni 59, no.1 (2021): 53 - 57. 10.4274/haseki.galenos.2021.6584
MLA Gokmen Karasu Ayse Filiz,Sahbaz Cigdem,EREN DOĞU Zeynep Filiz,Takmaz Taha,cali ozturk halime,TANOĞLU FATMA BAŞAK Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. Haseki Tıp Bülteni, vol.59, no.1, 2021, ss.53 - 57. 10.4274/haseki.galenos.2021.6584
AMA Gokmen Karasu A,Sahbaz C,EREN DOĞU Z,Takmaz T,cali ozturk h,TANOĞLU F Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. Haseki Tıp Bülteni. 2021; 59(1): 53 - 57. 10.4274/haseki.galenos.2021.6584
Vancouver Gokmen Karasu A,Sahbaz C,EREN DOĞU Z,Takmaz T,cali ozturk h,TANOĞLU F Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome. Haseki Tıp Bülteni. 2021; 59(1): 53 - 57. 10.4274/haseki.galenos.2021.6584
IEEE Gokmen Karasu A,Sahbaz C,EREN DOĞU Z,Takmaz T,cali ozturk h,TANOĞLU F "Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome." Haseki Tıp Bülteni, 59, ss.53 - 57, 2021. 10.4274/haseki.galenos.2021.6584
ISNAD Gokmen Karasu, Ayse Filiz vd. "Chronotype and Sleep Quality Assessment of Patients with Polycystic Ovary Syndrome". Haseki Tıp Bülteni 59/1 (2021), 53-57. https://doi.org/10.4274/haseki.galenos.2021.6584