TY  - JOUR
TI  - Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules
AB  - Aim: Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge.Inflammation has an important role in development of the malignancy. Therefore, inflammatory markers areassociated with malignant thyroid nodules. Platelet /lymphocyte ratio (PLR) is also one of the novelinflammatory indices derived from hemogram tests. We hypothesized whether PLR was associated withmalignant thyroid nodules. For this purpose, we compared PLR levels of the patients with benign thyroidnodules to the PLR of the subjects with malignant nodules.Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis ofthyroid nodule were enrolled to the present retrospective study. According to the examination of the fine needleaspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups.PLR of groups were compared.Results: Median PLR values of the benign and malignant thyroid nodule groups were 106 (48-432) % and 119(48-365) %, respectively (p=0.001). PLR value higher than 106% has 69% sensitivity and 51% specificity indetecting malignant nodules (AUC: 0.59, p=0.001, 95% CI: 0.54-0.65). PLR was positively correlated withTSH level (r=0.10, p=0.34).Conclusion: We suggest that elevated PLR could be an additional tool to differentiate malignant thyroidnodules from benign ones in supportive of sonography, scintigraphy and cytology.
AU  - kosekli, mehmet ali
AU  - kahveci, gizem
AU  - Bilgin, Satılmış
AU  - Kurtkulagi, Ozge
AU  - Atak, Burcin Meryem
DO  - 10.30714/j-ebr.2021267978
PY  - 2021
JO  - Experimental Biomedical Research
VL  - 4
IS  - 2
SN  - 2618-6454
SP  - 148
EP  - 153
DB  - TRDizin
UR  - http://search/yayin/detay/424544
ER  -