TY  - JOUR
TI  - Ameliorating Effects of Rutin on Nephrotoxicity Caused by Cisplatin in Rats
AB  - Cisplatin treatment in patients with solid tumor is common, but a major factor limiting its use isnephrotoxic effects. Thus, this study was performed to investigate the effects of rutin on oxidativestress, apoptotic protein caspase-3 and anti-apoptotic protein Bcl-3 levels in nephrotoxicity causedby cisplatin in rats. The rats were randomly separated into three groups (7 rats in each group).Group I was treated with physiological saline. Group II was treated with cisplatin intraperitoneallyon the tenth day of the study. Group III was treated with rutin 150 mg/kg orally for 14 days pluscisplatin 10 mg/kg intraperitoneally on the tenth day of the study. The kidneys and blood sampleswere collected for the measurement of urea, creatinine, malondialdehyde (MDA), glutathione(GSH), superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), caspase-3 andB-cell lymphoma protein 3 (Bcl-3) levels. Single dose cisplatin treatment in the rats caused thekidney injury. Rutin alleviated nephrotoxicity by significantly increasing antioxidant activity, anddecreasing MDA, caspase-3 and Bcl-3 levels (P<0.001). The present study suggested that rutincould decrease oxidative stress by enhancing antioxidant activity and nephrotoxicity caused bycisplatin by decreasing apoptotic pathways.
AU  - KÜÇÜKLER, Sefa
AU  - AKTAS, SINAN
AU  - Hanedan, Başak
AU  - ÇAĞLAYAN, Cüneyt
AU  - KANDEMİR, Fatih Mehmet
PY  - 2020
JO  - Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
VL  - 34
IS  - 3
SN  - 1308-9323
SP  - 147
EP  - 151
DB  - TRDizin
UR  - http://search/yayin/detay/424844
ER  -