Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study

Ozen, Nurten; Ünal, Nursemin; ATALAY, Filiz; Tosun, Betul

doi:10.14235/bas.galenos.2020.4016

Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study

Betül TOSUN, (Hasan Kalyoncu Üniversitesi, Sağlık Bilimleri Fakültesi, Gaziantep, Türkiye)

Nursemin ÜNAL, (Ankara Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Ankara, Türkiye)

Nurten OZEN, (Demiroğlu Bilim Üniversitesi, Florence Nightingale Hastanesi Hemşirelik Yüksekokulu, İstanbul, Türkiye)

Filiz ATALAY (Sağlık Bilimleri Üniversitesi, Farmasötik Teknoloji Anabilim Dalı, Gülhane Kampüsü, Ankara, Türkiye)

Bezmiâlem Science

5 2

Yıl: 2021 Cilt: 9 Sayı: 1 Sayfa Aralığı: 106 - 111 Metin Dili: İngilizce DOI: 10.14235/bas.galenos.2020.4016 İndeks Tarihi: 20-06-2021

Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study

Öz:

Objective: Administration of crushed medications can lead to various problems associated with use of inappropriate crushing method, such as administration of an incorrect dosage, alterations in drug bioavailability, and reduction in the effectiveness of the treatment. This experimental study aimed to compare the dosage loss of crushed metoclopramide hydrochloride (MT-HCI) 10-mg tablet using two crushing methods.Methods: MT-HCI 10 mg tablets (n=80) were crushed by two nurses, and each nurse used a pill crusher and a pestle and plastic bag to crush the tablet. Dosage loss was calculated by a specialist pharmacist in a laboratory environment.Results: The dosage loss was 0.515±0.299 mg (5.16%) with the pestle and self-sealing plastic bag and 0.415±0.359 mg (4.16%) with the pill crusher. No statistically significant difference was found between the two methods (p>0.05). The mean dosage loss was 0.482±0.367 mg for the first nurse and 0.449±0.298 mg for the second nurse. No statistically significant difference was noted in the mean dose between the two nurses (p>0.05).Conclusion: This study found no significant difference between the nurses and the crushing methods, but the mean dosage loss with both methods was not within the limits recommended by the United States Food and Drug Administration.

Anahtar Kelime:

İki Farklı Yöntemle ve İki Farklı Hemşire Tarafından Ezilen İlaçlar Arasındaki Doz Kaybının Karşılaştırılması: İn Vitro Çalışma

Öz:

Amaç: İlaçların ezilerek verilmesi, ilaçların uygun olmayan yöntemlerleezilmesi, yanlış dozda verilmesi, biyoyararlanımının değişmesi,tedavinin etkinliğinin azaltılması gibi birçok soruna yol açabilir. Budeneysel çalışma, farklı iki hemşire tarafından, iki farklı yöntemlemetoklopramid hidroklorür (MT-HCI) 10 mg tabletlerin ezildiktensonra, rezervuarda kalan doz kaybını karşılaştırmak amacıyla yapıldı. Yöntemler: MT-HCI 10 mg tabletler (n=80) iki araştırmacı hemşiretarafından iki farklı yöntemle ezildi. Her hemşire ezmek için her ikiyöntemi de (tablet ezici veya kilitli plastik torba içinde havaneli ileezilerek) kullandı. Tablet ezici ve plastic torba içinden ilaç alındıktansonra kalan doz kaybı laboratuvar ortamında uzman bir eczacıtarafından hesaplandı. Bulgular: Kalan doz kaybı, kilitli plastik torbada havaneli yöntemiyleezme yöntemiyle ortalama 0,515±0,299 mg, (%5,16) ve tablet eziciile 0,415±0,359 mg (%4,16) olarak hesaplandı. İki yöntem arasındaistatistiksel olarak anlamlı bir fark yoktu (p>0,05). Ortalama dozkaybı birinci hemşire için ortalama 0,482±0,367 mg ve ikinci hemşireiçin ortalama 0,449±0,298 mg idi. İki hemşire arasında kalan dozortlamaları açısından istatistiksel olarak anlamlı bir fark yoktu (p>0,05). Sonuç: Bu çalışma, ezme yöntemleri ile hemşireler arasında anlamlıbir fark olmadığını gösterdi. Ancak her iki yöntemde de ortalamadoz kaybı Amerika Birleşik Devletleri Gıda ve İlaç İdaresi tarafındanönerilen sınırlar içinde değildi.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tosun B, Ünal N, Ozen N, ATALAY F (2021). Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. , 106 - 111. 10.14235/bas.galenos.2020.4016
Chicago	Tosun Betul,Ünal Nursemin,Ozen Nurten,ATALAY Filiz Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. (2021): 106 - 111. 10.14235/bas.galenos.2020.4016
MLA	Tosun Betul,Ünal Nursemin,Ozen Nurten,ATALAY Filiz Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. , 2021, ss.106 - 111. 10.14235/bas.galenos.2020.4016
AMA	Tosun B,Ünal N,Ozen N,ATALAY F Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. . 2021; 106 - 111. 10.14235/bas.galenos.2020.4016
Vancouver	Tosun B,Ünal N,Ozen N,ATALAY F Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. . 2021; 106 - 111. 10.14235/bas.galenos.2020.4016
IEEE	Tosun B,Ünal N,Ozen N,ATALAY F "Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study." , ss.106 - 111, 2021. 10.14235/bas.galenos.2020.4016
ISNAD	Tosun, Betul vd. "Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study". (2021), 106-111. https://doi.org/10.14235/bas.galenos.2020.4016

APA	Tosun B, Ünal N, Ozen N, ATALAY F (2021). Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. Bezmiâlem Science, 9(1), 106 - 111. 10.14235/bas.galenos.2020.4016
Chicago	Tosun Betul,Ünal Nursemin,Ozen Nurten,ATALAY Filiz Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. Bezmiâlem Science 9, no.1 (2021): 106 - 111. 10.14235/bas.galenos.2020.4016
MLA	Tosun Betul,Ünal Nursemin,Ozen Nurten,ATALAY Filiz Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. Bezmiâlem Science, vol.9, no.1, 2021, ss.106 - 111. 10.14235/bas.galenos.2020.4016
AMA	Tosun B,Ünal N,Ozen N,ATALAY F Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. Bezmiâlem Science. 2021; 9(1): 106 - 111. 10.14235/bas.galenos.2020.4016
Vancouver	Tosun B,Ünal N,Ozen N,ATALAY F Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study. Bezmiâlem Science. 2021; 9(1): 106 - 111. 10.14235/bas.galenos.2020.4016
IEEE	Tosun B,Ünal N,Ozen N,ATALAY F "Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study." Bezmiâlem Science, 9, ss.106 - 111, 2021. 10.14235/bas.galenos.2020.4016
ISNAD	Tosun, Betul vd. "Comparison of Dosage Loss Between Medications Crushedwith Two Different Methods by Two Nurses: An In Vitro Study". Bezmiâlem Science 9/1 (2021), 106-111. https://doi.org/10.14235/bas.galenos.2020.4016