Repeated dose of prostaglandin E2 vaginal insert when the first dose fails

Karadag, Ceyda; Esin, Sertac; Yalvaç, Ethem Serdar; Karadag, Burak; Basar, Tugrul; Tohma, Yusuf Aytaç

doi:10.4274/tjod.galenos.2021.34119

Repeated dose of prostaglandin E2 vaginal insert when the first dose fails

Ceyda KARADAĞ, (Akdeniz Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Antalya, Türkiye)

Sertaç ESİN, (Başkent Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

Yusuf Aytaç TOHMA, (Başkent Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

Ethem Serdar YALVAÇ, (Bozok Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Yozgat, Türkiye)

Tuğrul BAŞAR, (Ankara Gölbaşı Şehit Ahmet Özsoy Devlet Hastanesi, Kadın Hastalıkları ve Doğum Kliniği Ankara, Türkiye)

Burak KARADAĞ (Antalya Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği Antalya, Türkiye)

Turkish Journal of Obstetrics and Gynecology

2 0

Yıl: 2021 Cilt: 18 Sayı: 1 Sayfa Aralığı: 50 - 55 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2021.34119 İndeks Tarihi: 20-06-2021

Repeated dose of prostaglandin E2 vaginal insert when the first dose fails

Öz:

Objective: To compare the obstetric and neonatal outcomes of patients treated with repeated-dose prostaglandin E2 (dinoprostone) vaginal insert whenthe first dose fails.Materials and Methods: This retrospective study included 1.043 pregnant women who received dinoprostone for labor induction between November2012 and August 2015. Pregnant women were divided into two groups according to the number of dinoprostone administrations: group 1, single-dosedinoprostone (n=1.000), and group 2, repeated-dose dinoprostone (n=43). Intrapartum, postpartum, and neonatal outcomes of the pregnant women werecompared.Results: Vaginal delivery rate was 65% in group 1 and 30.2% in group 2 (p=0.001). The need for the neonatal intensive care unit was found in 44 pregnantwomen (4.4%) in group 1 and 6 pregnant women (13.6%) in group 2 (p=0.006).Conclusion: When obstetric and neonatal data were evaluated in our study, we observed that dinoprostone administration was associated with increasedcesarean rates and adverse neonatal outcomes with repeated-dose dinoprostone when the first dose failed.

Anahtar Kelime:

İlk doz başarısız olduğunda prostaglandin E2 vajinal insertin tekrar kullanımı

Öz:

Amaç: İlk doz başarısız olduğunda tekrarlayan dozda prostaglandin E2 (dinoproston) vajinal ovül ile tedavi edilen gebelerin obstetrik ve neonatal sonuçlarını karşılaştırmayı amaçladık. Gereç ve Yöntemler: Bu retrospektif çalışmaya, Kasım 2012 ile Ağustos 2015 arasında doğum indüksiyonu için dinoproston alan 1,043 gebe dahil edildi. Gebeler dinoproston uygulama sayısına göre; grup 1: tek doz dinoproston, grup 2: tekrarlanan doz dinoproston olmak üzere 2 gruba ayrıldı. Tek doz dinoproston (n=1,000) ve iki dinoproston (n=43) alan gebelerin intrapartum, postpartum ve neonatal sonuçları karşılaştırıldı. Bulgular: Grup 1’de vajinal doğum oranı %65 iken, grup %30,2 idi (p=0,001). Yenidoğan yoğun bakım ihtiyacı grup 1’de 44 gebede (%4,4), grup 2’de 6 gebede (%13,6) görüldü (p=0,006). Sonuç: Çalışmamızda obstetrik ve neonatal veriler değerlendirildiğinde, ilk doz başarısız olduğunda tekrarlayan dinoproston dozu uygulanmasının artmış sezaryen oranları ve olumsuz neonatal sonuçlar ile ilişkili olduğunu gözlemledik.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Karadag C, Esin S, Tohma Y, Yalvaç E, Basar T, Karadag B (2021). Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. , 50 - 55. 10.4274/tjod.galenos.2021.34119
Chicago	Karadag Ceyda,Esin Sertac,Tohma Yusuf Aytaç,Yalvaç Ethem Serdar,Basar Tugrul,Karadag Burak Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. (2021): 50 - 55. 10.4274/tjod.galenos.2021.34119
MLA	Karadag Ceyda,Esin Sertac,Tohma Yusuf Aytaç,Yalvaç Ethem Serdar,Basar Tugrul,Karadag Burak Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. , 2021, ss.50 - 55. 10.4274/tjod.galenos.2021.34119
AMA	Karadag C,Esin S,Tohma Y,Yalvaç E,Basar T,Karadag B Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. . 2021; 50 - 55. 10.4274/tjod.galenos.2021.34119
Vancouver	Karadag C,Esin S,Tohma Y,Yalvaç E,Basar T,Karadag B Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. . 2021; 50 - 55. 10.4274/tjod.galenos.2021.34119
IEEE	Karadag C,Esin S,Tohma Y,Yalvaç E,Basar T,Karadag B "Repeated dose of prostaglandin E2 vaginal insert when the first dose fails." , ss.50 - 55, 2021. 10.4274/tjod.galenos.2021.34119
ISNAD	Karadag, Ceyda vd. "Repeated dose of prostaglandin E2 vaginal insert when the first dose fails". (2021), 50-55. https://doi.org/10.4274/tjod.galenos.2021.34119

APA	Karadag C, Esin S, Tohma Y, Yalvaç E, Basar T, Karadag B (2021). Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. Turkish Journal of Obstetrics and Gynecology, 18(1), 50 - 55. 10.4274/tjod.galenos.2021.34119
Chicago	Karadag Ceyda,Esin Sertac,Tohma Yusuf Aytaç,Yalvaç Ethem Serdar,Basar Tugrul,Karadag Burak Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. Turkish Journal of Obstetrics and Gynecology 18, no.1 (2021): 50 - 55. 10.4274/tjod.galenos.2021.34119
MLA	Karadag Ceyda,Esin Sertac,Tohma Yusuf Aytaç,Yalvaç Ethem Serdar,Basar Tugrul,Karadag Burak Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. Turkish Journal of Obstetrics and Gynecology, vol.18, no.1, 2021, ss.50 - 55. 10.4274/tjod.galenos.2021.34119
AMA	Karadag C,Esin S,Tohma Y,Yalvaç E,Basar T,Karadag B Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. Turkish Journal of Obstetrics and Gynecology. 2021; 18(1): 50 - 55. 10.4274/tjod.galenos.2021.34119
Vancouver	Karadag C,Esin S,Tohma Y,Yalvaç E,Basar T,Karadag B Repeated dose of prostaglandin E2 vaginal insert when the first dose fails. Turkish Journal of Obstetrics and Gynecology. 2021; 18(1): 50 - 55. 10.4274/tjod.galenos.2021.34119
IEEE	Karadag C,Esin S,Tohma Y,Yalvaç E,Basar T,Karadag B "Repeated dose of prostaglandin E2 vaginal insert when the first dose fails." Turkish Journal of Obstetrics and Gynecology, 18, ss.50 - 55, 2021. 10.4274/tjod.galenos.2021.34119
ISNAD	Karadag, Ceyda vd. "Repeated dose of prostaglandin E2 vaginal insert when the first dose fails". Turkish Journal of Obstetrics and Gynecology 18/1 (2021), 50-55. https://doi.org/10.4274/tjod.galenos.2021.34119