Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas
Yıl: 2020 Cilt: 13 Sayı: 2 Sayfa Aralığı: 119 - 124 Metin Dili: İngilizce DOI: 10.47027/duvetfd.794571 İndeks Tarihi: 22-06-2021
Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas
Öz: The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasiscapacity in various mammary carcinomas subtypes observed in dogs immunohistochemically with PCNA and MMP-9 markers. Thematerial of this study consisted of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of8.4 years brought to our department between 2012 and 2020. 4 of 10 mammary carcinoma cases were classified as intraductal papillarycarcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma. We found the highest mean number of PCNA andMMP-9 positive cells in solid subtype. In conclusion, there may be a positive relationship between cell proliferation, invasion andmetastasis capacity under the solid subtype.
Anahtar Kelime: Köpek Meme Karsinomlarında PCNA ve MMP-9 Ekspresyonlarının İmmunohistokimyasal Olarak Değerlendirilmesi
Öz: Bu çalışmanın amacı, köpeklerde görülen çeşitli meme karsinomu alt tiplerinde hücre proliferasyonu ile invazyon-metastaz kapasitesi arasında anlamlı bir ilişki olup olmadığını PCNA ve MMP-9 gibi immunohistokimyasal belirteçler aracılığıyla ortaya koymaktır. Bu çalışmanın materyali, 2012-2020 yılları arasında anabilim dalımıza getirilen yaş ortalaması 8,4 yıl olan 6 Kangal ve 4 Setter köpeğinden alınan meme kanseri doku örnekleri oluşturdu. 10 meme karsinomu vakasından 4'ü intraduktal papiller karsinom, 4'ü miks karsinom, 1'i solid karsinom ve 1'i tübüler karsinom olarak sınıflandırıldı. Solid alt tipte en yüksek ortalamada PCNA ve MMP-9 pozitif hücre sayısı bulundu. Sonuç olarak sadece solid alt tipte hücre proliferasyonu ile invazyon ve metastaz kapasitesi arasında pozitif bir ilişki olabileceği kanısına varıldı.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Karakurt E, DAĞ S, NUHOĞLU H, KURU M, Oral H, BEYTUT E, YILDIZ A (2020). Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. , 119 - 124. 10.47027/duvetfd.794571 |
| Chicago | Karakurt Emin,DAĞ SERPİL,NUHOĞLU HİLMİ,KURU Mushap,Oral Hasan,BEYTUT ENVER,YILDIZ Ayfer Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. (2020): 119 - 124. 10.47027/duvetfd.794571 |
| MLA | Karakurt Emin,DAĞ SERPİL,NUHOĞLU HİLMİ,KURU Mushap,Oral Hasan,BEYTUT ENVER,YILDIZ Ayfer Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. , 2020, ss.119 - 124. 10.47027/duvetfd.794571 |
| AMA | Karakurt E,DAĞ S,NUHOĞLU H,KURU M,Oral H,BEYTUT E,YILDIZ A Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. . 2020; 119 - 124. 10.47027/duvetfd.794571 |
| Vancouver | Karakurt E,DAĞ S,NUHOĞLU H,KURU M,Oral H,BEYTUT E,YILDIZ A Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. . 2020; 119 - 124. 10.47027/duvetfd.794571 |
| IEEE | Karakurt E,DAĞ S,NUHOĞLU H,KURU M,Oral H,BEYTUT E,YILDIZ A "Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas." , ss.119 - 124, 2020. 10.47027/duvetfd.794571 |
| ISNAD | Karakurt, Emin vd. "Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas". (2020), 119-124. https://doi.org/10.47027/duvetfd.794571 |
| APA | Karakurt E, DAĞ S, NUHOĞLU H, KURU M, Oral H, BEYTUT E, YILDIZ A (2020). Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 13(2), 119 - 124. 10.47027/duvetfd.794571 |
| Chicago | Karakurt Emin,DAĞ SERPİL,NUHOĞLU HİLMİ,KURU Mushap,Oral Hasan,BEYTUT ENVER,YILDIZ Ayfer Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. Dicle Üniversitesi Veteriner Fakültesi Dergisi 13, no.2 (2020): 119 - 124. 10.47027/duvetfd.794571 |
| MLA | Karakurt Emin,DAĞ SERPİL,NUHOĞLU HİLMİ,KURU Mushap,Oral Hasan,BEYTUT ENVER,YILDIZ Ayfer Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. Dicle Üniversitesi Veteriner Fakültesi Dergisi, vol.13, no.2, 2020, ss.119 - 124. 10.47027/duvetfd.794571 |
| AMA | Karakurt E,DAĞ S,NUHOĞLU H,KURU M,Oral H,BEYTUT E,YILDIZ A Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2020; 13(2): 119 - 124. 10.47027/duvetfd.794571 |
| Vancouver | Karakurt E,DAĞ S,NUHOĞLU H,KURU M,Oral H,BEYTUT E,YILDIZ A Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2020; 13(2): 119 - 124. 10.47027/duvetfd.794571 |
| IEEE | Karakurt E,DAĞ S,NUHOĞLU H,KURU M,Oral H,BEYTUT E,YILDIZ A "Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas." Dicle Üniversitesi Veteriner Fakültesi Dergisi, 13, ss.119 - 124, 2020. 10.47027/duvetfd.794571 |
| ISNAD | Karakurt, Emin vd. "Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas". Dicle Üniversitesi Veteriner Fakültesi Dergisi 13/2 (2020), 119-124. https://doi.org/10.47027/duvetfd.794571 |
